Correct Understanding Of Parkinson's, Know That Parkinson's Disease Is Not Afraid

Parkinson's disease is a common degenerative disease of the nervous system in the middle-aged and elderly. It is mainly manifested as slow movements, tremors in the limbs, loss of flexibility of the body, becoming rigid, writing smaller and smaller, pronunciation becoming more and more unclear, etc. Symptoms, but the strength of the muscles of the limbs is not significantly weakened. The earliest systematic description of the disease was by the British doctor James Parkinson, who named the disease "Parkinson's disease" in honor of the doctor, which is also known as "tremor paralysis" in China. If you have symptoms such as limb tremors, slow movements, muscle stiffness, and unclear speech, you should seek medical attention in time.

Motor symptoms, including resting tremor, muscle rigidity, bradykinesia, etc. Resting tremor is often the earliest manifestation detected and the main reason for seeking medical attention. The characteristic of resting tremor is that the tremor occurs in a still state, the hand posture is like rolling a pill, the tremor intensifies when the patient is emotional or nervous, and it can be completely disappeared during sleep. Some patients also experience stiffness of limbs or body, difficulty in fine movements, and slow movement. Also because the patient is not accompanied by resting tremors, these symptoms are often ignored by the patient or treated as arthritis, cervical and lumbar spondylosis, etc., even if they go to the neurology department, they may be treated as cerebrovascular disease.

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Therefore, everyone should know that in the motor symptoms of Parkinson's disease, slow movement is the most critical performance. Patients can feel that fine movements such as brushing teeth, beating eggs, rolling dumpling wrappers, tying buttons, and tying shoelaces are inflexible, and writing becomes smaller. When walking, the arm does not swing freely, the body leans forward, the pace becomes smaller, the expression becomes flat, etc. Some patients have only stiffness in the limbs and no tremors, which are called non-tremor Parkinson's. Patients who do not shake are most likely to be overlooked. Therefore, the diagnosis of Parkinson's disease, especially the early diagnosis, still requires the judgment of a very experienced neurologist, especially a doctor who specializes in Parkinson's disease.

Non-motor symptoms of Parkinson's disease, mainly include:

1. Psychoneurological symptoms: depression, anxiety, apathy, dementia, delirium, etc.

2. Sleep disorders: insomnia, excessive daytime sleepiness, multiple dreams, vivid dreams, restless legs syndrome, REM sleep behavior disorder, etc.

3. Autonomic dysfunction: frequent urination, urgency, increased nocturia, hyperhidrosis, orthostatic hypotension, falls, sexual dysfunction, etc.

4. Gastrointestinal symptoms: salivation, loss of taste, dysphagia, choking, nausea, constipation, etc.

5. Sensory disturbance: loss of sense of smell, numbness of limbs, pain, etc.

6. Other symptoms: fatigue, blurred vision, increased secretion of sebaceous glands, weight gain or loss, osteoporosis, etc.

Some of these non-motor symptoms occur after the motor symptoms of Parkinson's disease, such as mental retardation, more often appear before the motor symptoms of Parkinson's disease appear, and are throughout the entire disease process, For example, frequent urination, constipation, depression, loss of sense of smell, sleep disorders, especially one type of sleep disorder manifested as yelling, punching and kicking in sleep, most of which are accompanied by nightmares, as if they were acting out. We call it rapid eye movement sleep behavior disorder, or RBD for short, which often occurs several years or even more than ten years earlier than Parkinson's disease.

How is Parkinson's disease treated?

At present, western medicine's treatment of Parkinson's disease is mainly based on the replacement therapy of dopamine supplementation. However, the early application of large doses of levodopa preparations may accelerate the occurrence of motor complications. Therefore, in the early stage of Parkinson's disease, the clinical symptoms do not affect daily life. It is recommended to use traditional Chinese medicine, physiotherapy and physical therapy, etc., encourage patients to exercise more, sunbathe, drink green tea, maintain good living habits, and try to delay the use of Western medicines and doses. The dose is gradually increased until it can meet the daily work life. Surgical treatment (deep brain stimulation DBS) is an effective supplement to western medicine treatment. Rehabilitation treatment, psychological treatment, and good nursing can also improve symptoms to a certain extent.

Health advise for patients with Parkinson's disease

1. Exercise more: Scientific and appropriate exercise is good for the prevention of Parkinson's disease. Patients with Parkinson's should also exercise as much as they can under the guidance of a specialist. For example, asking patients to raise their legs, take big steps, and take a curved path is good for delaying the decline of motor function. For example, some soothing exercises such as Tai Chi can train the patient's balance.

2. Dietary attention: Parkinson's disease is a disease of the central nervous system, which can be accompanied by autonomic dysfunction, and patients are prone to constipation. It is recommended that patients with Parkinson's disease eat more crude fiber foods and fruits with laxative effects such as watermelon and bananas on the basis of a light diet. In addition, levodopa drugs should be taken on an empty stomach as much as possible, especially to avoid taking them at the same time with high-protein foods, so as not to affect the efficacy of the drugs.

3. Avoid contact with toxic chemicals: Toxic chemicals include pesticides, herbicides, pesticides, etc. At the same time, heavy metal manganese and radiation pollution should be avoided. People working in this area should pay attention to their isolation from risk factors.

4. Regular eating: eating time should be regular and fixed, and the amount of food should not be too large or too full. Secondly, in terms of dietary content, we must eat nutritious and easy-to-digest foods such as low protein, high vitamins, crude fiber, and so on.

5. Regular defecation: To achieve regular defecation, you should try to achieve it once a day, no more than 3 days at most, and it can be done in the morning or before going to bed.

6. Maintain the correct posture of the body: Pay attention to maintaining the correct sitting and standing postures and correct bad postures in daily life.

There is no cure for this disease, and the existing symptomatic treatment methods such as drug therapy, physical therapy, and traditional Chinese medicine can effectively improve the symptoms within a certain period of time. Therefore, improving and popularizing awareness of this disease can enable patients to be diagnosed early, treated early, and benefited early.

Echinacoside in Cistanche can improve the behavioral defects of MPTP-induced PD model mice, increase the striatal dopamine (DA) metabolite 3,4-dihydroxypheny lacetic acid (3,4-dihydroxypheny lacetic acid, DOPAC), and high Vanillic acid (homovanillic acid, HVA) content significantly inhibits the apoptosis of cerebellar granule neurons caused by the activation of caspase-3 and caspase-8; reduces the overexpression of biliverdin reductase B in the brain of Parkinson's patients, suggesting Echinacoside reduce the increase of biliverdin reductase B caused by oxidative stress through its anti-oxidative stress effect, and protect dopaminergic neurons from oxidative stress damage. Its neuroprotective mechanism may be similar to that of bile Decreased levels of chlorophyll reductase B are related; to the reduction of dopaminergic neurons and dopamine transporters in the substantia nigra of the brain of patients with Parkinson's disease, and can enhance neurotrophic factor [neurotrophic factor, NTF. brain-derived neurotrophic factor, BDNF) and nerves The activity and protein expression level of glial cell line-derived neurotrophic factor (GDNF) derived from the glial cell line can reduce the ratio of mRNA and protein in apoptosis and Bax/Bcl-2. In addition, echinacoside can significantly increase the content of dopamine, DOPAC, and HVA in the extracellular fluid of the striatum of patients with Parkinson's disease.

For more information: Ali.ma@wecistanche.com