Analysis Of Administration Rules Of Chinese Patent Medicine For Impotence Based On Data Mining

Abstract:

Objective: To observe the administration rules of Chinese patent medicine for impotence based on data mining. Methods: The Chinese patent medicine used for impotence in Drug Standard of Ministry of Public Health of the People's Republic of China: Chinese Traditional Compound Medicine.Chinese Pharmacopoeia, Pharmacopoeia of the People's Republic of China: Clinical Medication NoticeNational Standard Compilation of Chinese Patent Medicine, National Drug Standard: Standard of New DrugBecoming Official were screened and sorted. The usage frequency, effects, nature, flavors, and meridian. entries of Chinese medicines included in Chinese patent medicine were analyzed, and the administration rules of Chinese patent medicine for impotence were summarized by complex network analysis, factor analysis, and association rule analysis. Results: A total of 86 prescriptions were included, with 176 Chinese medicinals involved. The mostly used Chinese medicines are Lycii Fructus and Rehmanniae Radix Praeparata.Cuscutae Semen,Epimedh Folium, Cervi Cornu Pantotrichum, Angelicae Sinensis Radix and CistanchesHerba. Among them deficiency- supplementing medicinals, astringent medicinals, and dampness-draining diuretic medicinals take the majority; the main meridian entries of Chinese medicinals are the kidney meridian, the liver meridian, and the spleen meridian; Chinese medicinals with warm and balanced nature account for the most: the flavor is mostly acrid and sweet. in line with the association rule analysis, the core combination of medicinals is Rehmanniae Radix Praeparata- Dioscoreae Rhizoma- Poria- LyciFructus.

Traditional Chinese Medicine For Impotence Treatment

According to the complex network analysis, a total of six model combinations, including AngelicaeSinensis Radix- Astragali Radix- Glycyrrhizae Radix et Rhizoma- Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba- Cynomorli Herba, Cervi Cornu Pantotrichum- Ginseng Radix et Rhizoma-PolygalaeRadix-Ziziphi Spinosae Semem and Lyci Fructus-Schisandrae Chinensis Fructus-Rubi Fructus-DioscoreaeRhizoma-Poria-Cinnamomi Cortex-Psoraleae Fructus. The cluster analysis suggested four combinations of Chinese medicinals, including Rehmanniae Radix Praeparata- Angelicae Sinensis Radix- MorindaeOfficinalis Radix- Cistanches Herba- Cortex Eucommiae， Poria- Dioscoreae Rhizoma- Psoraleae Fructus-Schisandrae Chinenisis Fructus- Lycii Fructus, Astragali Radix- Glycyrrhizae Radix et Rhizoma and CerviCornu Pantotrichum- et Rhizoma Ginseng Radix. The combination of Chinese medicinals with the highest contribution rate in the factor analysis is Morindae Officinalis Radix-Eucommiae Cortex-Poria- Cistanches Herba. Conclusion; The core Chinese medicinals in the treatment of impotence by Chinese patent medicine Lycii Fructus， Rehmanniae Radix Praeparata, Cuscutae Semen, Epimedh Folium, Cervi CornuPantotrichum, Angelicae Sinensis Radix, and Cistanches Herba. The main treatment principle is to tonify the kidney and secure essence and enrich and nourish the liver and spleen, combined with promoting urination, clearing heat, and warming the middle energizer. ln clinical, modified prescriptions, such asWubi Shanyan Pills, Meiwei Dihuang Pills and Five-Seed Progeny Pills can be used for treatment based on syndrome differentiation.

Impotence refers to the inability of adult men to have normal sexual intercourse because of the impotence of the penis or unable to maintain a full and sustained erection during sexual intercourse and is unable to have normal sexual dysfunction [1]. The incidence and severity of impotence in recent years have been increasing. In recent years, the incidence and severity of impotence In recent years, the incidence and severity of impotence have been on the rise, causing serious effects on patients[2] . The incidence and severity of impotence have been on the rise in recent years, with serious consequences for patients[2] . Western medicine often uses phosphodiesterase type 5 inhibitors (PDE5i), implantation of penile prostheses, and vacuum suction devices, but there are many problems such as long treatment time, adverse However, there are many problems such as long treatment time, adverse reactions, and high price[3-5] . The treatment of impotence with TCM has a long history. Chinese medicine has a long history of treating impotence and has Chinese medicine has a long history of impotence treatment and has rich experience in the treatment of impotence. The clinical treatment often adopts the methods of tonifying the kidney and strengthening the Yang, benefiting the essence and filling the marrow, activating blood circulation and removing blood stasis, etc., which can by regulating the patient's sex hormone levels to maintain normal sexual function[6-8].

In this study, the data mining method was used to analyze the grouping of Chinese patent medicines for impotence treatment. In this study, we used a data mining method to analyze the formula pattern of Chinese patent medicines for the treatment of impotence and provide a reference for clinical Chinese patent medicines for the treatment of impotence.

Cistanche tubulosa (1)

1 Data and methods

1.1 Sources Screening of Chinese patent medicines related to the treatment of impotence in the Drug Standard of the Ministry of Health of the People's Republic of China: Prepared Chinese Medicines [9], Chinese Pharmacopoeia [10], Chinese Pharmacopoeia Clinical Use Instructions: Prepared Chinese Medicines Volume [11], National Compilation of Standards for Proprietary Chinese Medicines [12], and National Drug Standard: New Drug Conversion Standard [13].

1.2 Inclusion criteria

Using impotence, yin impotence, tendon impotence, yin-vessel non-use, and inactivity as search terms, relevant prescriptions were screened in the above literature; the included prescriptions must contain clear drug composition, efficacy, and main treatment; if there were multiple compositions of duplicate pCms, the more recent data were retained.

Cistanche tubulosa (5)

1.3 Exclusion criteria

The prescriptions contained drugs that were not included in the 2020 edition of the Chinese Pharmacopoeia [10], the "Thirteenth Five-Year Plan" textbook of the National Higher Institute of Traditional Chinese Medicine "Traditional Chinese Medicine" [14], the Dictionary of Traditional Chinese Medicine [15], and the Chinese Materia Medica [16], or had incomplete information on taste, internal organs and meridians, etc.; the main ingredients of the pCms contained western drugs. The main ingredients of Chinese patent medicines contain western drugs.

1.4 Data standardization

The Chinese Pharmacopoeia [10] was used as the standard for recording the names of the Chinese medicines, and reference was made to the "Thirteenth Five-Year Plan" textbook of the National Higher Institute of Traditional Chinese Medicine, "Traditional Chinese Medicine" [14], "Dictionary of Traditional Chinese Medicine" [15] and "Chinese Materia Medica" [16] for the standardization of the names of the medicines. The same drug is not distinguished by region, concoction method, or alias, but is standardized as the same drug name, such as silkworm moth, male silkworm moth, silkworm moth oil, and silkworm moth residue are unified as original silkworm moth, but those with large differences in taste and efficacy are still recorded as different drugs, such as raw groundnut and ripe groundnut. Only the drugs of the basic formula were included, not counting the drugs added or subtracted by the clinical evidence; the modifiers to the properties and flavors were removed, such as slightly cold and slightly sweet were unified as cold and sweet.

1.5 Statistical analysis of data

The data were entered by two persons into Microsoft Excel 2010 worksheet by two people and then submitted to the third party for review and proofreading to establish.

The data were entered into Microsoft Excel 2010 worksheet by 2 persons individually and submitted to the 3rd party for review and verification to establish a database of prescriptions for the treatment of impotence with Chinese patent medicines. Microsoft Excel 2010 and different algorithms of complex network, factor analysis and association rules were used to The frequency of use, flavor and meridian, efficacy category, and drug combination of Chinese medicines were analyzed. The analysis was conducted by using Microsoft Excel 2010 and different algorithms of complex network, factor analysis and association rules.

2.4 Taste Statistics of Chinese Medicine

Chinese medicines can be divided into five categories according to their medicinal properties According to the nature of herbal medicines, they can be divided into five categories: cold, hot, warm, cool and flat, and one herbal medicine corresponds to one kind of nature. The results showed that the total frequency of herbal medicines was 1,173 times, among which the highest frequency was for warm medicines (675 times). The highest frequency was 675 times (57.54%) for warm medicines, followed by 302 times (25.75%) for flat medicines. The highest frequency was 675 times (57.54%) for warm medicines, followed by 302 times (25.75%) for mild medicines and 141 times (12.02%) for cold medicines. Chinese medicines can be divided into seven types of flavors: pungent, sweet, bitter, salty, sour, astringent and light. The total frequency of 176 herbal flavors was 1,958 times, of which the frequency of use was 1,908 times.

The total frequency of 176 herbal flavors was 1,958 times, among which the highest frequency was 913 times for sweet flavor, followed by 352 times for pungent flavor and 352 times for bitter flavor. The total frequency of 176 herbal flavors was 1,958, among which the most frequent was sweet flavor 913 times, followed by pungent flavor 352 times, bitter flavor 307 times and salty flavor 149 times.

2.5 High-frequency drug association analysis

Apriori algorithm of IBMSPSS Modeler 18.0 was used to analyze the association of 16 high-frequency drugs with minimum conditional support (S) ≥ 20%, minimum rule confidence (C) ≥ 80%, maximum number of antecedents of 3, and lift (L) ≥ 1.0. 6 two-item, 15 three-item, and 4 four-item drug associations were included in the results. By simplifying the network combination of the resulting drug pairs or drug combinations with increasing support, the strength of the association between drugs can be more clearly visualized. When setting the support degree ≥ 30%, the core drug combination of Shu Di Huang - Shan Yao - Fu Ling - Lycium barbarum is shown.

2.6 Complex network analysis

See Figure 3 and Table 5. 1 node in the network represents 1 drug, 1 edge connecting 2 nodes represents 2 drugs used in the same prescription, and the eigenvector centrality can reflect the convergence frequency and importance of nodes. The results showed that the node degree of Lycium barbarum was 143, the tightness was 0.842, and the eigenvector centrality was 1, ranking 1st, which was the most important core node in the network. Module 1: Angelica sinensis - Astragalus membranaceus - Glycyrrhiza glabra - Atractylodes macrocephala - Paeonia lactiflora - Lock Yang; Module 2: Deer antler - Ginseng - Yuan Zhi - Ziziphus sour; Module 3: Fructus Lycii - Schisandra chinensis - Raspberry - Yam - Poria - Cinnamon - Tonic bone; Module 4: Radix et Rhizoma raw - Asparagus - Macrocephalus - Radix rehmanniae - Eucommia - Zedoaria; Module 5: Radix Bacopa monniera - Cistanche cistannii - Achyranthes bidentata; Module 6: Radix et Rhizoma lactiflora - Achyranthes bidentatae. -Module 6: Epimedium - Semen Cuscutae.