Drugs Are One Of The Common Causes Of Parkinson's Syndrome
Mar 01, 2022
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Drugs are one of the common causes of Parkinson's syndrome: drugs that block postsynaptic dopamine receptors and/or deplete presynaptic dopamine can cause Parkinson's syndrome. Research data shows that drug-induced Parkinson's syndrome Symptomatic syndrome accounts for about 39.36% of the total prevalence of Parkinson's syndrome, which is significantly higher than that of vascular Parkinson's syndrome (14.87%). In recent years, with the development and application of new drugs, its incidence has gradually increased. Some drugs that can cause Parkinson's syndrome, I hope readers and friends will pay attention to the clinical selection.
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Dopamine receptor blockers are the most common and representative drugs that cause drug-induced parkinsonism. These drugs exert antipsychotic effects by blocking the mesolimbic pathway and the substantia nigra pathway; Dopamine receptors in the striatal pathway can reduce dopamine function and cause Parkinson's syndrome.
1. Phenothiazine drugs, which are derivatives of phenothiazine, can be divided into aliphatic (such as ampromazine), piperidine (such as thioridazine), piperazine ( Such as perphenazine, fluphenazine, trifluoperazine) among which perphenazine, fluphenazine, triflupromazine, trifluoperazine and other drugs are more likely to cause Parkinson's syndrome The extrapyramidal side effects of drugs such as drazine are weak, but about 28.98% of patients who take a large amount of ampromazine for a long time will develop Parkinson's syndrome
2. Jacylbenzene drugs, such as haloperidol and trihaloperidol, are more likely to cause Parkinson's syndrome, but the effect is weaker than that of phenothiazines.
3. Benzamide derivatives, such drugs are widely used and are more convenient to use. For example, sulpiride can be used in the treatment of patients with depression as a palliative antipsychotic; drugs such as metoclopramide and morphine have central effects. Constantly blocking the action of gastrointestinal smooth muscle dopamine receptors can improve the function of the digestive tract. However, these drugs can pass through the blood-brain barrier for a long time and are prone to Parkinson's syndrome, so a small amount of short-term application is recommended. Antidepressants tricyclics Antidepressants and tetracyclic antidepressants act on the dopamine system and can cause Parkinson's syndrome. Among them, 8-hydroxyisopentiapine has a more significant effect on dopamine receptors, similar to haloperidol. Dopamine-depleting drugs represent drug benefits. Xueping is a kind of alkaloid with antihypertensive effect; antihypertensive is a total alkaloid preparation. The antihypertensive effect is weaker than reserpine. The two have similar structural effects, and they are depleted by preventing Yuanbu from ingesting dopamine. The dopamine in Yuan bubbles can cause Parkinson's syndrome. Class, I calcium antagonists such as Sibilin, Naoyizine, and other drugs can selectively block the excessive influx of calcium ions. When they are used in patients with cerebral vasoconstriction, Endogenous dopamine has a significant blocking effect, and Parkinson's syndrome will appear after a few weeks of medication. In addition, Parkinson's syndrome caused by flunarizine accounts for about 19.96% of all taking such drugs. Antiarrhythmic Drugs such as amiodarone can cause muscle rigidity, and it is inferred that amiodarone has adverse reactions that damage the basal ganglia of the brain. In order to avoid the occurrence of drug-induced Parkinson's syndrome, clinical medication should be intentional: 1. Avoid Using antidepressants and calcium channel blockers at the same time; 2. Avoid using drugs that cause Parkinson's syndrome as much as possible. When you must use them, you should start with a small dose and should not be used for a long time, and closely observe their performance after medication;
4. Women and elderly people need to be cautious about medication. In short, the symptoms of drug-induced Parkinson's syndrome are similar to those of Parkinson's disease. Generally, symptoms appear 120 to 180 days after administration, and those who take the drug for more than 12 months are different, but drug-induced The prognosis of Parkinson's syndrome is generally good. After stopping the drug, the clinical symptoms will improve. Continuing to use the drug will make the clinical symptoms worse. Therefore, early and correct identification and correct treatment are very important. It should be noted that some patients with slow recovery effects can be treated. Use anti-Parkinsonian drugs, but try to avoid the use of levodopa. Long-term use of levodopa will cause nausea, loss of appetite, etc., and elderly patients will also experience dizziness and palpitations. If it is caused quickly, if it is not recommended to reduce the dose for relief, long-term use of levodopa drugs will also cause some motor system complications unique to Parkinson's disease, such as end-of-dose phenomenon, switching phenomenon, dyskinesia and so on.
