Part 3 Chronic Kidney Disease And Aging Differentially Diminish Bone Material And Microarchitecture in C57Bl/6 Mice

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Highlights

CKD and aging differentially affected bone material properties.

CKD altered bone collagen nanomechanics.

CKD and aging both reduced cortical and trabecular microarchitecture.

Osteocyte lacunae may participate in phosphate mineral homeostasis in CKD.

Figure 2:Bone quality changes with aging and CKD from the tissue scale to the whole-bone scale.

At the whole-bone scale, A) aging reduces whole-femur strength and modulus while B)CKD reduces toughness only at middle-age. From C) representative nanoindentation maps, aging reduces modulus while aging and CKD have opposite effects on the standard deviation of modulus, an indicator of bone heterogeneity. At the nanoscale, E) CKD increases the SAXS percent collagen strain at maximum strain, which F) negatively correlates with toughness for CKD but not Sham mice. Significant main effects are noted with text, while significant post-hoc effects are indicated by *.

Data are presented as mean+/-standard error of the mean. P-values for the main effects of age and CKD as well as their interaction are reported in the left column. Post-hoc testing was performed for measures with a significant interaction between age and CKD

Indicates a significant difference between Sham and CKD at the same age(p<0.017, Bonferroni-adjusted critical a), while percent differences between Sham and CKD are noted when p<0.05.

Data are presented as mean +/-standard error of the mean. P-values for main effects of age and CKD as well as their interaction are reported in the left column.