These Abnormal Symptoms Of The Body, Be Careful Of Nephritis

The kidney is an important excretory organ of the human body, which filters the blood of the human body. Like a water purifier, it helps the human body purify the blood and discharge excess waste. However, as time goes by, if the kidneys are not properly protected, It will lead to the accumulation of waste in the body, which will have a greater impact on human health over time. So, how is chronic nephritis formed? Can chronic nephritis be cured? What are the principles of daily diet? How to prevent chronic nephritis?

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How is chronic nephritis formed?

Chronic nephritis is the abbreviation of chronic glomerulonephritis, which is a group of primary glomerular diseases composed of a variety of different etiologies and different pathological types. The etiology of the disease is unknown. There are usually upper respiratory tract infections or infections in other parts before the onset of the disease. A small number of chronic nephritis may evolve from nephritis after acute streptococcal infection, but most chronic nephritis does not result from acute nephritis. Chronic nephritis is the onset of chronic nephritis.

Because chronic nephritis is not an independent disease, its pathogenesis is different, most of which are immune complex diseases, which can be deposited by circulating soluble immune complexes in the glomerulus, or by antigens and antibodies in situ to form the immune system in the glomerulus complex that activates complement causing tissue damage. Instead of immune complexes, the bacterial toxins, metabolites, etc. deposited in the glomerulus can activate complement through the "bypass system", thereby causing a series of inflammatory responses and leading to glomerular inflammation.

At present, many scholars believe that chronic glomerulonephritis may be caused by various bacterial, viral, or protozoal infections through immune mechanisms, inflammatory mediators, and non-immune mechanisms. When there is a problem with the kidneys, the body will have some abnormal symptoms.

The early symptoms of chronic nephritis mainly include:

1. Fatigue, loss of appetite

Some of the early clinical symptoms are mainly fatigue and loss of appetite, which appear early in some patients.

2. Low back pain

In the early days, I felt a little uncomfortable in the waist, a dull pain, and some dull pains.

3. Edema

The early edema is generally not serious, only some edema in some parts of the face and eyelid with relatively loose tissue, sometimes it is more obvious when getting up in the morning, and some patients may have no edema.

There are still many patients who do not have any symptoms in the early stage. They only find hematuria and proteinuria in the urine routine during the physical examination. They are suspected of nephritis and are admitted to the hospital for treatment.

What are the consequences and complications of chronic nephritis if left untreated?

1. Infection

Long-term proteinuria leads to a large amount of protein loss, malnutrition, and immune dysfunction, which are prone to various infections. Such as respiratory tract infection, urinary tract, and skin infection, and infection as a malignant stimulus, often induces acute exacerbation of chronic nephritis, making the disease progressively aggravated. Although there are a variety of antibiotics to choose from, infection is still the main cause of acute exacerbation of chronic nephritis if treatment is not timely or thorough, and it should be taken seriously.

2. kidney anemia

kidney parenchymal damage occurs in the late stage of chronic nephritis, which can be complicated by various abnormalities of the blood system, such as anemia, abnormal platelet function, abnormal lymphocyte function, and coagulation mechanism disorders. Anemia is the most common complication. The main causes of anemia are: decreased production of red blood cells; increased destruction of red blood cells: in kidney failure, uremic toxins accumulate in the body, and red blood cell metabolism is hindered and easily destroyed, resulting in hemolysis, leading to anemia. Blood loss: About 25% of patients with end-stage kidney failure have significant bleeding, and aggravating anemia.

3. Hypertension

In chronic nephritis and kidney insufficiency, serious cardiovascular complications such as hypertension, atherosclerosis, cardiomyopathy, pericarditis, and kidney insufficiency often occur, mainly due to chronic nephritis and kidney insufficiency (CRF) itself Caused by abnormal metabolism during development. According to statistics, the incidence of hypertension is 70% to 80%, and almost all patients requiring kidney replacement therapy have hypertension. Among them, 3/4 of patients can control hypertension with a low-salt diet and dialysis, and the other 1/4 of patients use After dialysis removes excess sodium and water from the body, blood pressure rises instead. In addition, hypertension in CRF patients has its inherent characteristics, manifested as the loss of the trend of nocturnal physiologic blood pressure decline, and some of them can be classified into isolated systolic hypertension.

4. Chronic kidney failure

Chronic nephritis will eventually lead to chronic kidney failure, but the rate of progression of the disease varies greatly among individuals, which is mainly related to the type of pathological damage, the presence of complications (especially hypertension), the importance of protecting the kidneys, and the appropriateness of treatment.

What are the treatments for chronic nephritis?

In the early stage of chronic glomerulonephritis, corresponding treatment should be given according to its pathological type, mainly drug treatment, to inhibit immune-mediated inflammation, inhibit cell proliferation, and reduce kidney sclerosis. The main purpose should be to prevent or delay the progressive deterioration of kidney function, improve or relieve clinical symptoms, and prevent and treat comorbidities. Emphasize rest, avoid strenuous exercise, restrict diet, and prevent infection. The following comprehensive treatment measures can be used:

1. Actively control high blood pressure

Prevents kidney insufficiency or improves already impaired kidney function, prevents cardiovascular complications, and improves long-term prognosis.

2. Reduce urinary protein

To delay the decline of kidney function, proteinuria is closely related to the decline of kidney function, so it should be strictly controlled. ACEIs and ARBs have the effect of reducing urinary protein, and their doses often need to be higher than their blood pressure-lowering doses. But should prevent the occurrence of hypotension.

3. Limit protein and phosphorus intake in food

A low-protein and low-phosphorus diet can reduce glomerular hypertension, hyperperfusion and hyperfiltration, and delay glomerulosclerosis. Patients with kidney insufficiency azotemia should limit the intake of protein and phosphorus, adopt a high-quality low-protein diet or add essential amino acids or α-keto acids.

4. Avoid factors that aggravate kidney damage

Infection, hypovolemia, dehydration, fatigue, water-electrolyte, acid-base balance disorders, pregnancy, and the use of nephrotoxic drugs (such as aminoglycoside antibiotics, non-steroidal anti-inflammatory drugs, contrast agents, etc.) maybe be be damage the kidneys. Should be avoided or used with caution.

5. Glucocorticoids and cytotoxic drugs

Because chronic nephritis is a clinical syndrome including a variety of diseases, its etiology, pathological type and degree, clinical manifestations and kidney function are quite different. Therefore, whether to use glucocorticoids and cytotoxic drugs should be based on the etiology and pathological types. Sure.

Can chronic nephritis be cured? 

What is the standard of clinical cure?

To be precise, chronic nephritis cannot be cured! For the more common chronic nephritis represented by IgA nephropathy, due to irreversible changes in the inflammatory kidney tissue, even after active treatment, there will be long-term proteinuria, hematuria, etc., even in the long run. gradually progressed to uremia. In other words, most nephritis cannot be cured. Only a part of chronic nephritides, such as minimal change nephropathy, can be completely turned negative in urine tests after treatment, and there is no permanent change in the morphology of kidney tissue, so this kind of disease can be regarded as cured or cured in the end.

Although chronic nephritis cannot be cured, the vast majority of patients only carry proteinuria or microscopic hematuria after appropriate treatment and live a normal life without any abnormality. Because chronic nephritis is characterized by a long course of the disease, it will progress slowly and continuously. But that is to say, medically speaking, this is a slow process, but it does not mean that there is no cure. This is true of all diseases with the title of "chronic". Of course, "incurable" does not mean "terminal illness", but "incurable disease". On the contrary, if you seek medical treatment early and have a reasonable diet, chronic nephritis can be completely controlled, and it will not become as incurable as everyone realizes.

Prevention of chronic kidney disease is very important. What can we do on weekdays to better protect our kidneys? What is the principle of the daily diet for patients who have been diagnosed with chronic nephritis?

The protection of the kidney needs to be carried out from many aspects. First of all, you should pay attention to drinking more water, and the daily water intake should be 1000-2000ml to promote the excretion of metabolites in the body. Kidney-damaging drugs, such as gentamicin, sulfonamides, and anti-inflammatory pain relievers, should be avoided. At the same time should also pay attention to preventing colds and tonsillitis, so as not to induce acute nephritis. Usually should reduce the intake of beverages, beer, and foods containing more salt, so as not to increase the burden on the kidneys. Usually, you can pay attention to exercise, enhance physical fitness, combine work and rest, live a normal life, and avoid factors such as overeating and overwork that increase the burden on the kidneys.

Why Cistanche Can Treat Nephritis

Cistanche is one of the nine Chinese fairy herbs. It is as famous as ginseng, Ganoderma lucidum, and Cordyceps Sinensis. The medicinal effect of Cistanche is listed as the top grade in the "Shen Nong's Classic of Materia Medica", so it has been used as a traditional Chinese medicinal material in China for more than 2,000 years. Modern pharmacological activity studies have shown that Cistanche is rich in phenylethanoid glycosides with verbascoside and echinacoside as the iconic components, which can increase the proliferation rate of human kidney cells by 8-10 times. Cistanche can protect renal tubular cells, prevent kidney interstitial lesions, slow down the rate of nephritis, and also effectively prevent secondary bacterial infections in patients with chronic kidney failure.

for more information:Ali.ma@wecistanche.com