What Factors Can Lead To Elevated Creatinine in Patients With Kidney Disease? What Methods Are Available To Effectively Lower Creatinine?

Creatinine is a product of human muscle metabolism. In human muscle, creatine slowly forms creatinine mainly through an irreversible non-enzymatic dehydration reaction, and then releases into the blood and excretes with urine. Therefore, the reason why blood creatinine is high is closely related to the total amount of muscle exercise in the body.

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Creatinine is a small molecular substance that can be filtered through the glomeruli and is rarely reabsorbed in the renal tubules. Almost all creatinine produced in the body is excreted with urine every day and is generally not affected by urine output.

What does elevated creatinine mean?

When the creatinine value is higher than 133 μmol/L, it belongs to the renal function compensation period, and the glomerular damage is relatively mild at this stage;

When the creatinine value is higher than 177 μmol/L, it belongs to the stage of renal insufficiency. At this stage, the number of glomerular sclerosis and fibrosis increases, and kidney damage increases;

When the creatinine value is higher than 442μmol/L, it belongs to the stage of renal failure. During this stage, the renal function has declined to an irreversible stage, and kidney cells are killed every moment;

When the creatinine value is higher than 707 μmol/L, the kidney has entered the end stage of renal insufficiency, that is, the end stage of uremia.

Because the kidney has a strong compensatory function, under normal circumstances, when the glomerular damage reaches more than 60%, and the kidney excretes waste to a certain extent, there will be a rapid increase in serum creatinine. When the serum creatinine is significantly higher than the normal value, it means that the damage to renal function has become serious.

What are the causes of elevated serum creatinine?

There are two reasons for the increase in serum creatinine. One is a physiological reason, which is a normal phenomenon, and the other is a pathological reason, which means that there is a problem with the kidneys.

Physiological reasons, don't worry too much, but you need to pay more attention!

1. Overworked

Excessive fatigue in life, excessive physical exertion, excessive sexual intercourse, and energy consumption can also cause an increase in the body's blood creatinine.

2. Excessive consumption of meat

If you overeat a large amount of meat on the day before the physical examination, which exceeds the excretion of the kidneys, the exogenous creatinine will increase, which will easily lead to an increase in blood creatinine. Generally, the creatinine value rises due to excessive meat eating. Don’t worry too much. As long as you adjust your diet, the creatinine value will return to normal.

3. Vigorous exercise

Serum creatinine is produced by muscles. After excessive strenuous exercise, the muscles contract and the body is in a state of high catabolic metabolism. Serum creatinine will also rise. In this case, it can usually return to normal after rest.

Pathological reasons need to be highly valued, and treatment cannot be ignored!

1. Patients with high blood pressure

Long-term hypertension, severe proteinuria persists, and the condition is not controlled in time. The disease process will be accompanied by elevated creatinine.

2. Dehydration

The body sweats a lot, drinking less water, and the human body is prone to dehydration. The increase in urine output will lead to blood concentration and blood concentration. If you don’t pay more attention, it may cause creatinine to rise.

3. Nephrotoxic drugs

Taking drugs that are more harmful to the body, especially nephrotoxic drugs that are more harmful to the kidneys in patients with kidney disease, will lead to an increase in the body's blood creatinine.

4. Infection

Renal patients with renal insufficiency, if combined with infections, including colds, pneumonia, intestinal infections, urinary tract infections, etc., may have elevated serum creatinine in a short period.

5. Chronic renal failure

Primary nephropathy, such as membranous nephropathy, LGA nephropathy, etc. leads to impaired glomerular filtration function, which reduces the excretion of creatinine by the kidneys, resulting in elevated serum creatinine.

To sum up, there are many reasons for the increase in serum creatinine, but what needs to be reminded is that if the increase in serum creatinine is caused by the first four pathological reasons, if it can be treated in time, the renal function can be restored. Yes, if the treatment is not taken seriously, it may aggravate the condition and cause chronic renal failure. When it reaches the stage of chronic renal failure, it will be more difficult to control the condition, so the treatment time must not be delayed.

The increase in creatinine is related to the meat diet. I have seen many patients with kidney disease who are afraid of exacerbation of kidney disease and control their diet and nutrition. As a result, the creatinine is too low, which is malnutrition. And some kidney disease patients do not pay attention to diet and often eat a lot of "red meat" (beef, mutton, dog meat, and rabbit meat are all red meat), which leads to a rapid increase in creatinine and has gone to another extreme.

Elevated creatinine is also associated with disease, and I have had several patients with acutely elevated creatinine due to upper respiratory infections. Endotoxins, toxoids, and exotoxins produced by bacterial infections can aggravate damage to the body and lead to elevated creatinine.

Many patients are afraid of taking medicine when they have an upper respiratory tract infection, fearing that the side effects of the medicine will damage the kidneys and lead to renal failure. The side effects of drugs can be reduced by drinking more water and speeding up drug metabolism. The kidney damage caused by the toxin formed by the infection, and the renal failure caused by it is far greater than the toxic side effects of the drug.

How to lower creatinine

1. Chinese medicine detoxification. Improve immunity, increase lung and liver functions, and reduce creatinine through liver detoxification, lung respiration, sweating, and other methods.

2. Detoxification, improves kidney function by promoting blood circulation and increases urination to detoxify.

3. Moisten the intestines and laxative, reduce stool to detoxify. Be careful not to detoxify by using rhubarb for diarrhea, long-term use of rhubarb can cause anemia.

4. Physical methods to reduce creatinine, such as colon dialysis, and peritoneal dialysis, the side effect is easy infection; in hemodialysis, the side effect is to cause renal ischemic atrophy. Currently, the safest and most effective method is colon dialysis to reduce creatinine.

Haorentang Traditional Chinese Medicine Hospital uses these methods in combination, using traditional Chinese medicine to improve immunity, detoxify and detoxify laxatives, and other methods to reduce creatinine and protect kidney function.