2022 Top 10 Selected Good Articles in Nephrology
Jan 11, 2023
It's time for an annual review. How has the past year been for you? Learn the new by reviewing the past, we will continue to classify and inventory the popular articles, reviews, cases, guideline consensus, etc. published in 2022 for readers. The following are popular articles:
TOP 1: Academician Liu Zhihong: Re-understanding the Glomerular Filtration Barrier and Related Diseases
On August 4, 2022, at the 2021 Academic Annual Meeting (CSN 2021) of the Nephrology Branch of the Chinese Medical Association, academician Liu Zhihong, director of the Eastern Theater General Hospital and the National Clinical Research Center for Kidney Diseases, made a presentation on "re-understanding glomerular Filtration Barriers and Related Diseases". Academician Liu Zhihong pointed out that the study of such diseases represented by Alport syndrome should start with the analysis of disease gene variation, which will provide a new way to systematically understand the abnormal structure and interaction of the glomerular filtration barrier, and provide a new way for such diseases. The complexity of genetic variation, the diversity of clinical phenotypes, and the importance of genetic diagnosis have brought new understanding, thereby improving its diagnosis and treatment.
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TOP 2: Clinical Essentials: Diagnosis and Treatment of Metabolic Alkalosis
Metabolic alkalosis is a common acid-base balance disorder in clinical practice. When the arterial blood pH value is ≥7.55, the risk of death increases significantly. The kidney is an important organ to maintain acid-base balance, so metabolic alkalosis is often associated with kidney disease. The etiology of metabolic alkalosis is diverse. Physicians need to pay attention to the patient's clinical manifestations, complete the examination as soon as possible, and ask about the medical history in detail, to correct the metabolic alkalosis urgently and treat the cause at the same time, reducing the risk of recurrence of the patient.
TOP 3: ASN Kidney Week 2022 was successfully held, and the "revolution" in nephrology started
On November 3-6, 2022, US Eastern Time, the 2022 American Society of Nephrology Annual Meeting - ASN Kidney Week, the world's highest-level kidney academic event, was successfully held in the United States. The conference brought together experts and scholars in the field of nephrology from around the world, providing an excellent platform for participants to present and exchange the latest academic progress in the field. Professor Susan E. Quaggin, Chairman of ASN, pointed out at the opening ceremony that compared with before 2015, the progress in the management of nephropathy has been advancing by leaps and bounds, giving people reason to believe that nephrology is about to face a "revolution"!
TOP 4: Professor Zhao Minghui: Progress in research and diagnosis and treatment of complement and kidney disease
Complement plays an important role in some kidney diseases. Targeting complement could improve the treatment and prognosis of related kidney diseases. On August 7, 2022, at the 2021 Academic Annual Meeting (CSN 2021) of the Nephrology Branch of the Chinese Medical Association, Professor Zhao Minghui, director of Peking University First Hospital and Peking University Institute of Nephrology, made a presentation on "Complement and Kidney-related Diseases ", and concluded that complement activation is involved in the pathogenesis of a variety of kidney diseases, but to varying degrees in each kidney disease. At present, it is unclear which renal diseases warrant complement inhibitory therapy, and more research is needed.
TOP 5: Does proteinuria necessarily mean kidney disease? These situations require special attention
The presence of proteinuria does not mean that there is a problem with renal function, and everything from infection to excessive exercise may lead to proteinuria or microalbuminuria. In fact, according to the definition of chronic kidney disease (CKD) in the KDIGO clinical guidelines, the staging of kidney disease also needs to estimate the glomerular filtration rate (eGFR), which reflects from the side that the diagnosis of kidney disease is not just proteinuria. index.
TOP 6: The latest research confirms that increasing the number and time of dialysis per week will help the recovery and prognosis of dialysis patients!
It has been demonstrated that the duration of the post-dialysis recovery period (DRT) is inversely associated with quality of life in patients with end-stage renal disease (ESRD). How should the time of DRT be shortened? Studies from the United States have shown that if ESRD patients receive hemodialysis 5 times a week and the cumulative dialysis time is 14 hours, the time of DRT will be shortened, which will help the recovery and prognosis of patients, and reduce the risk of death and hospitalization.
TOP 7: Do hemodialysis patients still need uric acid-lowering treatment? The latest research shows that it may be possible to stop the drug
Hyperuricemia is a common complication in CKD patients, which can cause arthritis and increase the risk of death. Many CKD patients use urate-lowering drugs in the early stage. However, hemodialysis can reduce blood uric acid. For dialysis patients who have progressed to ESRD, is it necessary to continue uric acid-lowering treatment? This study shows that hemodialysis can remove excess uric acid, and hemodialysis patients with hyperuricemia may stop using urate-lowering drugs.
TOP 8: Dialysis patients are at high risk of vascular calcification, is vitamin K supplementation useful?
This study is the largest randomized controlled trial of the effect of vitamin K on cardiovascular disease in hemodialysis patients. The researchers believe that vitamin K supplementation can improve related indicators in hemodialysis patients, but whether it can reduce the risk of vascular calcification in hemodialysis patients still needs further research. Moreover, no studies have yet demonstrated that vitamin K supplementation reduces the risk of adverse cardiovascular events in hemodialysis patients with high coronary artery calcium scores (CAC).
TOP 9: Professor Wan Jianxin: Normal albuminuria, diabetes, and kidney disease
The latest data show that the mortality and disability-adjusted life years of diabetes-related CKD patients in my country are increasing yearly. On August 6, 2022, at the 2021 Academic Annual Meeting (CSN 2021) of the Nephrology Branch of the Chinese Medical Association, Professor Wan Jianxin from the First Affiliated Hospital of Fujian Medical University combined the "Chinese Guidelines for Clinical Diagnosis and Treatment of Diabetic Kidney Disease" and research Progress, shared the key points of diagnosis and treatment of normoalbuminuric diabetic kidney disease.
TOP 10: Summary and emerging concepts of management methods for hemodialysis hypotension
Hemodialysis patients are prone to hemodialysis hypotension (IDH), which not only affects the treatment and quality of life of patients but may also cause death. On February 24-27, 2022, the 2022 World Congress of Nephrology (WCN) was successfully held in Kuala Lumpur, the capital of Malaysia. Experts from various countries elaborated on the management and new concepts of IDH and looked forward to the early and widespread clinical application of new technologies and new concepts.
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