At What Level Of Creatine Do You Need Dialysis?Read This To Understand
Dec 26, 2022
Creatinine is the final product of the normal metabolism of creatine in the body's skeletal muscles. For normal people, the amount of creatinine produced daily is constant, and the production of creatinine is closely related to human muscle mass (especially is a skeletal muscle) proportional to. Therefore, men usually have slightly higher values than women; regular muscle-building athletes and "meat eaters" also have higher values.
Creatinine is the normal breakdown product of creatine in the muscles and is excreted in the urine by the kidneys. Since creatinine will not be reabsorbed after being filtered out from the glomerulus to the renal tubules, and the rate of production (creatine metabolism) is stable without other sources or influences (such as diet, exercise), when "glomerular If there is a problem with the GFR, the creatinine will remain and accumulate in the blood, resulting in a high value during the test. Therefore, the level of blood creatinine can be used to evaluate the quality of renal function.
Normal value of creatinine: 0.7～1.2 mg/dl
Creatinine value Meaning
Regardless of gender: 0.5-0.9 ~1.0-1.5 mg/dl
or
Male: 0.7~1.5 mg/dl
Female: 0.6~1.3 mg/dl
normal value
≧2.0 mg/dl renal failure
≧7.0 mg/dl Uremia
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Specimens should be anticoagulated with serum or heparin, and the serum should be separated as soon as possible to avoid hemolysis. Avoiding strenuous exercise eight hours before blood sampling is more important than fasting. The normal reference value suggested by the laboratory is regardless of gender: 0.5-0.9 ~ 1.0-1.5 mg/dl or male: 0.7 ~ 1.5 mg/dl; female: 0.6 ~ 1.3 mg/dl. Generally, when the creatinine test value exceeds 2.0 mg/dl for more than four times on different days, it is generalized renal failure; if it is higher than 7.0 mg/dl, uremia may have developed.
What does high or low creatinine mean?
Theoretically, the creatinine value is quite stable, unlike BUN, which is not easily affected by protein and water, only muscular people are slightly higher than short and thin people. Creatinine rises in muscle hypertrophy; nephritis, nephropathy, renal vascular embolism; congestive heart failure; nutritional disorders, etc. In addition, it has been seen clinically that the creatinine value of the blood test in the evening is generally 20 to 40% higher than that during the day.
Creatinine is a stable renal function test index, which is often used to evaluate renal dysfunction and monitor the condition of kidney disease, but it is not suitable for early kidney disease screening. The reason is that when creatinine is measured several times in a row with high values, it means that the condition of kidney disease is usually bad enough to be irreversible.
Creatinine is the residue after protein metabolism, and human muscle is also composed of protein. Therefore, men with more muscular muscles, athletes, and people who love meat will have higher creatinine values; on the other hand, the kidneys of pregnant women The Spheroid Filtration Rate will increase and therefore the creatinine value will be lower.
Zhu Shuwei, a nephrologist at the Affiliated Hospital of China Medical University, pointed out that the increase in creatinine value may be related to increased meat intake and ketoacidemia, and does not necessarily affect the renal glomerular filtration rate; if the human body has reduced muscle mass, inflammation or malnutrition, The creatinine value may also decrease.
Creatinine is too high
renal failure
Nephritis
urinary tract obstruction
Uremia
acute muscle injury
Low creatinine
chronic muscle damage
thin
Pregnant
How to improve creatinine
It suggested that creatinine higher than the normal value may mean that the kidney function is less than half. Therefore, patients with chronic kidney disease must pay more attention to treatment and diet in order to maintain kidney function. Avoid the fate of dialysis. Treatment options include:
1. Strictly control blood pressure (below 130mmHg/85mmHg)
2. Reduce proteinuria
3. Adopt a low-protein diet (less than 0.6 grams of protein per kilogram of body weight per day)
4. Patients with symptoms of hypertension, heart failure or edema need to adopt a low-salt diet (less than 3 grams per day); other patients should adopt a salt-restricted diet (4-6 grams per day)
5. Avoid risk factors that harm kidney function, such as drug abuse, dehydration, urinary tract obstruction, infection, and electrolyte imbalance
6. If you have symptoms of severe renal failure such as oliguria and edema, you should adopt a low-potassium diet
7. Avoid rapid weight loss and increase the burden on the kidneys
8. Treatment of diseases such as diabetes that cause decreased kidney function
9. Quit smoking to avoid continued deterioration of kidney function
