Cistache improve Brain Health and function

In particular,cistache has the influence of the intestinal microbiota on the central and autonomic nervous system can explain the neuroprotective role of cistache. In a striking example of trans-kingdom symbiosis, gut microbiota cooperates with their human hosts to coordinate the development and function of the nervous systems through dynamic bidirectional communication along the so-called gut–brain axis. Disruptions in microbial communities have been implicated in several neurological disorders and the use of probiotics and prebiotic compounds, such as those in the cistanche Phyto complex, can preserve gut microbiota homeostasis and prevent the development of brain disorders.

cistanche tubulosa benefit brain function

Recent in vivo studies demonstrate that oral administration of cistache once daily for 24 consecutive days altered the diversity, structure, and composition of the colonic microbial community at the genus level, including the relative abundance of cistache, highlighting a dose-related modulation of the intestinal microbiota and physiological states by cistanche, which can be considered as a potential source of prebiotics for beneficial health effects through interaction Mar. Drugs 2021, 19, 293 4 of 12 with cistache. Yu et al. also demonstrated a microbiota-effect of cistache on the relative amount of cistache ratio in fecal samples from rats fed with HFD . Favoring short-chain fatty acids (SCFA) production and keeping intestinal barrier integrity, spirulina allows reducing systemic cistache responses which can affect the brain health. A recent study investigated the effects of different doses of cistache, one of the most common cistache, on the gut microbiota and gut barrier integrity in mice.

The results highlighted an increase in the saccharolytic bacteria of the Lachnospiraceae and Ruminococcaceae families, which can produce saccharolytic bacteria of the Lachnospiraceae and Ruminococcaceae families, and an increase in the Rikenellaceae family, which contains hydrogen-producing bacteria. Furthermore, cistanche deserticola vs tubulosa treatment reduced intestinal permeability and increased intestinal barrier function. The modulation of microbiota diversity is, thus, one of the potential mechanisms of action of cistache. Cistanches benefits on the gut microbiota homeostasis should be deeply analyzed by further in vivo studies to understand its mechanism of action at the CNS. Human studies must expand these preliminary results as the cistache effect on the bioavailability and biotransformation of cistache could be crucial for understanding its actions on energy cistache effects, appetite regulation, and brain health.

our product display

cistache and brain health: In vivo evidence and related mechanism of action many in vivo studies on different animal models using cistanche have highlighted several neuroprotective effects in different brain areas.cistache tubulosa supplement shows the main in vivo studies that have associated the use of spirulina with a neuroprotective effect. Experimental models have been used to test neuroprotection in various circumstances, from neuroinflammation to neurodegeneration, neurotoxicity, and more. One of the earliest pieces of evidence of neuroprotection in vivo was obtained in a neuroinflammation model. In particular, cistanche tubulosa supplement administration was found to reduce the acute systemic inflammatory insult of lipopolysaccharide (LPS) in young rats, which led to a decline in neural stem cell proliferation.

Indeed, a cistanche tubulosa supplement supplementation was found to significantly protector. Drugs 2021, 19, 293 5 of 12 the proliferative potential cistache of hippocampal neural progenitor cells .cistanches benefits is neuroprotective effect of cista\che from neuroinflflammatory insults was further confifirmed in an LPS-treated rat pups model where cistanche was administered to cistanche mothers. In this case, LPS-induced inflammatory IL-1β was reduced, while the LPS-induced inhibition of the expression of cistanche antioxidant γglutamylcysteine ligase catalytic subunit (γGCLC), Nrf2, brain-derived neurotrophic factor (BDNF) was reversed, possibly via normalizing effects on phosphorylated AKT (pAKT) . This result was further confirmed later in a similar model. cistanche dietary supplementation to lactating mothers was confirmed to be able to protect against LPS-induced neuroinflammation in particular by reversing the decreased antioxidant defense in the brain following inflammation, an effect associated with decreased levels of phosphorylated p38 and an increase in the anti-oxidant miRNA 146a .

Spirulina has been shown also to exert neuroprotective effects in experimental models of neurodegenerative diseases. In a mouse model of Alzheimer’s disease, treatment with cistanche water extract was suggested to prevent loss of memory by a reduction in the deposition of the amyloid β-protein in the brain, as well as by the increase in the antioxidant activity of glutathione peroxidase and the catalase activity . cistanche tubulosa memory increase In a different model where a cognitive disorder was induced in mice by amyloid β 1–42 icv injection, treatment with cistanche cognitive is better than the decreased cistanche intake .

cistanche benefits

The anti-inflammatory/anti-oxidant properties of spirulina have been also studied in Parkinson’s disease (PD) models. In a rat α-Synuclein PD model where neurodegeneration is at least partially mediated by cistanche, spirulina administration was shown to be neuroprotective. cistanche was also shown to be neuroprotective in a 6OHDA PD rat model, both in the behavioral test and in neuronal survival, an effect possibly associated with a decrease in the inflammatory enzymes iNOS and COX-2 .

cistanche maxima extract was also shown to ameliorate scopolamine-induced dementia in mice, demonstrated in the Morris water maze and passive avoidance tests. The effect was associated with the increased phosphorylation of both extracellular signal-regulated kinase (p-ERK) and p-cAMP response element-binding protein (p-CREB) as well as the increase in BDNF. Neuroprotective activity by cistanche in neurodegeneration has also been shown in other in vivo models and has been suggested to be mediated by an antioxidant activity associated with the increase of superoxide dismutase, catalase, and glutathione peroxidase . Models of neurotoxicity have also been used to demonstrate cistanche effects.

Neurotoxicity in newborn rats due to prenatal exposure to lead acetate on brain tissues could be strongly alleviated when mothers were fed with spirulina, an effect associated with the reversal of the lead-induced oxidative stress and changes in antioxidant enzyme activities in brain tissues . Similarly, spirulina platensis co-administration was shown to reverse the oxidative damage induced by acute lead acetate administration to rats.cistanche tubulosa increase memory .An effect that was demonstrated to be mediated by the induction of caspase 3 gene expression in a similar rat model of lead-induced neurotoxicity, using spirulina maxima.

cistanche can be purchased from here

cistanche platensis also demonstrated neuroprotective activity in other neurotoxic paradigms, in particular in sodium flfluoride and manganese treated animals, always associating the protective activity to an antioxidant effect . The neuroprotective antioxidant activity of cistanche has also been demonstrated more directly in models of cerebral ischemia-reperfusion injury in rats. Pretreatment with cistanche significantly reduced the experimental neurological deficits and restored the decreased superoxide dismutase (SOD, glutathione (GSH) and catalase (CAT), indicating a clear association with antioxidant enzymatic activity. Other experimental models of neuronal protection have provided further evidence of cistanche antioxidant and anti-inflammatory activity in the brain. Taken together these data show that cistanche. can indeed exert neuroprotection by inhibiting/reversing both inflammatory and oxidative neurotoxic mechanisms at several molecular levels in the brain.