Is Parkinson's Disease Hereditary?

Many Parkinson's patients ask a question; "Will Parkinson's disease is passed on to my children?" I believe this is also a problem that many Parkinson's disease patients are particularly concerned about. Poor parents all over the world, even if they suffer from Parkinson's disease, they are most worried about their children.

In response to the question of whether Parkinson's disease is hereditary：

      The exact cause of Parkinson's disease is still unknown. The occurrence of Parkinson's disease may be related to the degeneration and death of dopaminergic neurons in the substantia nigra. Genetic factors, environmental factors, aging, and oxidative stress may all be involved in the process of deformation and death of dopaminergic neurons in Parkinson's disease.

      Now there are also studies showing that dysbiosis in the gut flora can cause Parkinson's disease, or a dysregulation of the autoimmune system can also cause Parkinson's disease.

      Of course, Parkinson's disease may also be a disease caused by multiple genes and multiple factors. For example, when you have the LRRK2 gene in your body, a cold may make you have Parkinson's disease.

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      In general, the inheritance factor of Parkinson's disease accounts for a small proportion, about 5% to 10%. Most Parkinson's disease patients are not inherited, but if it is a genetically related Parkinson's disease, it has a certain degree of inheritance.

      Then some Parkinson's patients will ask, my family, does not suffer from Parkinson's disease, will my child have problems? Most people with Parkinson's disease are not hereditary, we call it sporadic Parkinson's disease. Such patients may carry some risk gene mutations, which make the risk of Parkinson's disease higher than those who do not carry them. The greater the number of genetic mutation sites, the greater the risk of developing the disease.

      Speaking of which, everyone may be worried. Does that mean that when we get sick, our children will definitely have problems? Actually not. Even if you have a positive risk gene test result, it doesn't necessarily mean you have the disease. Just like people with high blood lipids are prone to stroke, it does not mean that high blood lipids will definitely cause a stroke. And people with low blood lipids are not necessarily immune to disease. Risk genes play a similar role in disease. In addition to risk genes, other risk factors and protective factors need to be considered in the pathogenesis of Parkinson's disease. Individuals who do not carry risk genes may have a higher risk than those with positive risk genes if they have multiple other risk factors. Therefore, the risk factors of Parkinson's disease should be looked at comprehensively and objectively in order to accurately and correctly predict the risk of the disease and formulate relevant coping strategies.

Patients with a genetic family history of Parkinson's generally have the following two characteristics:

       1. There is obvious family aggregation performance, and there are people in almost every generation.

       2. Early age of onset: It usually occurs before the age of 40, and the disease progresses very quickly. The tremor familial type has a higher incidence and less family history of rigidity, which may be recessive inheritance.

       Parkinson's disease, as a common neurodegenerative disease, frequently occurs in the elderly, with an average age of onset around 60 years old. The exact etiology of this pathology is still unclear, genetic factors, environmental factors, aging, oxidative stress, etc. may all lead to this disease.

The causes of Parkinson's disease are generally divided into the following:

      The incidence of Parkinson's disease increases with age, and it is more common in people over 60 years old. In recent years, the incidence of Parkinson's disease also has had a younger trend. The onset before the age of 40 is called juvenile Parkinson's disease, and the incidence is relatively small.

      That causative gene is associated with familial Parkinson's disease. 5~10% of Parkinson's disease patients have a family history, and genetic factors are also one of the factors in the pathogenesis of Parkinson's disease. Therefore, patients with related genes, such as the LRRK2 gene and family history, are more likely to have Parkinson's disease. sick.

      That drug use, exposure to herbicides, and pesticides can easily lead to Parkinson's disease, while smoking and caffeine intake have a certain protective effect, making it difficult for people to develop Parkinson's disease.

      Of course, everyone can't smoke as much as smoking, and drinking coffee have protective effects, because smoking will also increase the risk of lung cancer and cardiovascular and cerebrovascular diseases. Smoking in order to prevent Parkinson's disease increases the risk of lung cancer and cardiovascular and cerebrovascular diseases.

      In conclusion, the pathogenesis of Parkinson's disease is still unclear, and there are various hypotheses. If you have Parkinson's disease, don't be afraid. Active treatment, control of symptoms, and improvement of quality of life are our common goals.

How should I take treatment of Parkinson's disease, 

     Now with the development of medical technology, both western medicine, and traditional Chinese medicine have made great contributions to the treatment of Parkinson's disease. As a traditional technology, traditional Chinese medicine has a relatively obvious effect on the prevention and treatment of Parkinson's disease, especially the herbal cistanche on Parkinson's disease. The treatment can get a good inhibitory effect, and in the process of taking the drug, it can well avoid the side effects caused by western medicine, protect the liver and kidney function of the patient, and the drug effect will be relatively more stable.

Echinacoside in Cistanche can improve the behavioral defects of MPTP-induced PD model mice, increase the striatal dopamine (DA) metabolite 3,4-dihydroxypheny lacetic acid (3,4-dihydroxypheny lacetic acid, DOPAC), and high Vanillic acid (homovanillic acid, HVA) content significantly inhibits the apoptosis of cerebellar granule neurons caused by the activation of caspase-3 and caspase-8; reduces the overexpression of biliverdin reductase B in the brain of Parkinson's patients, suggesting Echinacoside reduce the increase of biliverdin reductase B caused by oxidative stress through its anti-oxidative stress effect, and protect dopaminergic neurons from oxidative stress damage. Its neuroprotective mechanism may be similar to that of bile Decreased levels of chlorophyll reductase B are related; to the reduction of dopaminergic neurons and dopamine transporters in the substantia nigra of the brain of patients with Parkinson's disease, and can enhance neurotrophic factor [neurotrophic factor, NTF. brain-derived neurotrophic factor, BDNF) and nerves The activity and protein expression level of glial cell line-derived neurotrophic factor (GDNF) derived from the glial cell line can reduce the ratio of mRNA and protein in apoptosis and Bax/Bcl-2. In addition, echinacoside can significantly increase the content of dopamine, DOPAC, and HVA in the extracellular fluid of the striatum of patients with Parkinson's disease.