Study On The Optimal Specification Of Herba Cistanches Fuju Pieces Ⅱ

Table 4 Quality test results of different specifications of Cistanche deserticola slices and traditional slices

Table 5 Comparison results of the homogeneity between traditional and chewed pieces

Table 6 Quality attributes of 15 batches of traditional decoction pieces and decocted

HERBAL CISTANCHE SUPPLEMENTS WITH HIGH ANTI-OXIDATION PROPERTIES

4 Discussion

The term "Fuju" has a long history of application. Its original meaning is "containing flavor", which means "chewing with the mouth" and "biting with the mouth". Through textual research, "Fuju" is a processing method that processes drugs into made-sized pieces for decoction and subsequent production. Although Chinese herbal medicine pieces have evolved for thousands of years, they are still presented in a simple and extensive form during processing and use. The volume, weight, and quality attributes of the pieces of the same batch vary greatly, the adjustment is inconvenient and the decoction is not thorough. The reason is that the selection of the specifications of the pieces is unreasonable and there is a lack of scientific evaluation methods. "Fuju" pieces are an innovative application of traditional processing methods. They are optimized from the "shape" to reduce the size of traditional pieces, giving them the advantages of high utilization rate, uniform quality, stable efficacy, and convenient adjustment and preparation. At the same time, the characteristics of traditional pieces are retained, which greatly improves their fluidity and effectively solves the problems existing in traditional pieces.

Cistanche belongs to a large-volume Chinese medicinal material. Through research, it was found that the quality differences between its upper, middle, and lower parts are large. Based on this, this study first used the traditional pieces of Cistanche deserticola as a bridge to carry out the optimization of the specifications of the pieces. Cistanche deserticola has many internal components, mainly phenylethanoid glycosides, iridoid terpenes, lignans, and polysaccharides. Among them, the phenylethanoid glycoside components echinacoside and verbascoside are the indicator components specified in the "Chinese Pharmacopoeia" and are also the effective ingredients of Cistanche deserticola. They have good effects in anti-oxidation, anti-aging, anti-tumor, and memory improvement [7-10].

The decoction rate and the transfer rate of verbascoside and echinacoside are used as the internal component evaluation indicators to ensure the consistency of the quality attributes of the pieces of Cistanche deserticola with traditional pieces. Secondly, the angle of repose is used to evaluate the fluidity of the pieces, which is conducive to the development of the corresponding dispensing equipment for the pieces of Cistanche deserticola, so that the later clinical dispensing can be automated and intelligent, providing greater convenience for hospitals and patients. In addition, compared with boiled and loose pieces and formula granules, fu-jugated pieces will not lose the identification characteristics of the original pieces. Instead, they are a new type of pieces developed and designed to ensure that their decoction rate and active ingredient transfer rate are equivalent to those of traditional pieces while retaining the characteristics of conventional pieces. This is designed to facilitate the identification and supervision of pieces, while ensuring that the usage and dosage of pieces remain stable, thereby providing a more reliable and convenient solution for clinical application.

The results showed that except for the feature of "arranged in wavy rings", different specifications of fu-jugated pieces retained the characteristics of traditional pieces. In addition, it is generally believed that the smaller the angle of repose, the smaller the friction and the better the fluidity, and no more than 30° is the ideal state [11-12].

Compared with traditional pieces, the angle of repose of fu-jugated pieces is smaller than that of traditional pieces, and the angle of repose of 5 mm and 8 mm cubes is more consistent, and the fluidity is more ideal. First, the scoring results of the decoction rate, and transfer rate of verbascoside and echinacoside showed that the quality attributes of the cubes with a size of 8 mm were close to those of traditional slices. Secondly, the uniformity of traditional slices and thick slices of Cistanche were evaluated respectively, and the results showed that the uniformity of 8 mm cubes was significantly better than that of traditional thick slices. In addition, the quality consistency evaluation of traditional slices and thick slices prepared from multiple batches of Cistanche from different production areas showed that the quality attributes of 8 mm cubes of thick slices of Cistanche were consistent with those of traditional slices.

In summary, the 8mm cubic block specification shows excellent fluidity, high uniformity, and consistency of quality attributes in the preparation of Cistanche deserticola chewable slices, and is suitable for making Cistanche deserticola chewable slices.

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