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Parkinson's disease is a disease of the central nervous system that occurs in middle-aged and elderly people. In people over 60 years old, the prevalence rate is about 10%, and there is little difference between China and foreign countries.

Cistanche is very good for Parkinson's disease

1. Possible side effects of most Parkinson's disease drugs

1 Neuropsychiatric side effects

L-dopa-induced hallucinations are a relatively common side effect, although relatively rare early in treatment. Some studies suggest that in the first two years of levodopa treatment, the incidence of hallucinations is only 3.3%, but with the prolongation of medication time, the incidence of hallucinations is also increasing. In addition, older patients are also more prone to hallucinations.

In addition, COMT inhibitors, selegiline, amantadine, and anticholinergic drugs have also been reported to cause hallucinations. L-dopa, all dopamine agonists, and anticholinergics have the potential to cause disturbances of consciousness, especially in elderly patients and those with cognitive impairment. Anticholinergic drugs often cause cognitive impairment, including memory loss, decreased concentration, and frontal lobe dysfunction.

2 sleep disorders

Parkinson's disease itself is also closely related to sleep disorders, so when Parkinson's patients have sleep disorders, it is difficult to judge whether the performance is due to the progression of the disease itself or the side effects of anti-Parkinson's drugs. For example, the occurrence of sleep disturbances in PD increases with patient age, levodopa dose, and the occurrence of the "on-off phenomenon". Generally speaking, when it comes to sleep disorders caused by anti-Parkinson's disease drugs, the first thing we think of is selegiline. It is generally believed that it should be taken before noon, and in short, it should not be taken in the evening and evening. In fact, levodopa and all dopamine agonists may be associated with insomnia. In addition, amantadine may also cause sleep disorders. Excessive daytime sleepiness is quite common in Parkinson's patients. Epidemiological surveys suggest that 16% of Parkinson's patients may have this condition, which may be related to disease progression. Treatment with levodopa is associated with cognitive impairment.

3 Gastrointestinal reactions

Nausea and vomiting are very common gastrointestinal side effects of antiparkinsonian drugs, but are uncommon in untreated Parkinson's disease patients. Up to 80% of patients will experience anorexia, nausea, vomiting and epigastric discomfort, heartburn, bloating and other symptoms when they first start using levodopa.

In addition, nearly all antiparkinsonian drugs have the potential to cause nausea, including selegiline, all dopamine agonists, and the COMT inhibitors tolcapone and entocapone. Anorexia is the more common side effect of tolcapone and selegiline. This side effect may cause transient weight loss. Diarrhea is a very common non-dopaminergic side effect when patients are treated with COMT inhibitors, and can occur even after patients stop taking the drug. Reports have also reported that entacapone and darlingfu (stalevo, a mixture of entacapone, carbidopa, and levodopa) can cause enteritis.

Levodopa and dopamine agonists often cause orthostatic hypotension. In addition, ergot alkaloids and non-ergot agonists of dopamine receptors may cause a sudden drop in blood pressure, although symptoms may occur in only a small proportion of patients, and this response occurs on first application, so Dopamine agonists should be started in small doses and titrated slowly. Among dopamine agonists, pramipexole is the only drug that is considered to be free from orthostatic hypotension in monotherapy. Both selegiline and COMT inhibitors (tocapone and entocapone) may cause orthostatic hypotension.

It is important for Parkinson's patients to find the right treatment for them!

Rational drug use is the most important link in the fight against Parkinson's disease. Taking medication is a long process, and many "payous" have concerns about drugs because they are worried about the side effects of western medicines. In fact, with the development of medical technology, western medicine and traditional Chinese medicine have made great contributions to the treatment of Parkinson's disease. If Western medicine is not effective, it can be treated with traditional Chinese medicine, and sometimes traditional Chinese medicine can produce "miraculous effects". As a traditional technique of traditional Chinese medicine, Dr. Wang Shilong's clinical experience in treating Parkinson's patients for 20 years has been summed up. , can well avoid the side effects caused by western medicine!

Three stages of treatment:

The first stage is mainly to calm the liver and calm the wind, calm the abnormal liver yang, and relieve the main complaints. Build confidence for patients to overcome their disease.

The second step is to nourish the kidney, nourish the essence, nourish the blood and nourish the yin, eliminate the basis for the formation of symptoms, and seek the cause of the disease. Start from the source and consolidate the curative effect.

The third step is to regulate the zang-fu organs and balance yin and yang. The ancient words "yin and yang are secretive, and the spirit can be cured", "righteousness is stored in the body, and evil cannot be dry". to resist evil