When Naproxat Mesylate Is Used For Hemodialysis, What Causes Instant Turbidity With 5%GS Configuration?

Today, before Nemostat mesylate on the machine, a new drying syringe configuration, using 20ml5%GS to configure 100 mg napathmostat a lot of turbid, may I ask you have encountered this situation? Then another new syringe to extract the same bottle of sugar, take two of the same batch number (the same box) naphthalmostat configuration clear no turbidity phenomenon.

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Why is sugar water so cloudy?
We mix it with 5% glucose and you don't get clumps and cloudiness
Salt water mix can cause turbidity
Naphthalamus diluted with saline and that's it
Why does this happen with glucose?
Be transparent
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Subject: The sugar used for dilution is placed there, and you told me that the salt water configuration will be cloudy.
Is it made with sugar?
Sugar should be flocculent when it is dissolved in water?
Is it cloudy with sugar water?
We have not used sugar water here, only once the nurse used salt water to mix the like you picture.
What is the reason?
Maybe this bottle of sugar is mislabeled.
We dissolved it in sugar the other day, and when we put a dozen in salt water, it turned muddy.
Salt water can be really cloudy
I think it's salt water, too
Sometimes 5ml/piece is not good
That happened to me, too
Occasionally this may happen
Same scene
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Subject: If it is not 5% sugar preparation turbidity, I do not deserve to send this circle of friends. Do not evaluate low-level mistakes, please analyze the possible deep-seated reasons, thank you.
Could the syringe have been pumped with saline?
Is that the drug itself?
Should I fill in the adverse event of the drug device?
I tried that once
We've had them, too, because the patient brought his own medicine and exposed it in the car
Sometimes we see it all the time
Same box of pills, same bottle of sugar water, two things have not changed, only the syringe is the variable.
There's still a drug buddy problem
Some people say, wait for a while to melt it
I've only encountered one that reacts with sodium bicarbonate
We also encountered a case where 5% sugar was formulated with flocculent, and the manufacturer said that no other hospital had ever seen this situation, and now there is.
It's kept at room temperature away from light, and we have a patient here who puts it in the fridge and takes it out of the sugar water configuration where the small particles form into group crystals in about a minute or 20 minutes

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"Knowledge point"

From the Nanjing Medical University Run Run Shaw Hospital teacher Zhang analysis:

1, mistakenly mixed with other ionic solutions; Using a syringe with other drugs drawn, the normal saline, citrate, heparin, etc., and other anionic electrolytes containing phosphate, bicarbonate, sulfate, nitrate or lactic acid can be exchanged with the mesylate of naphamoxat mesylate, resulting in precipitation.

2, change the PH of the solution, change the pH of the solution: it will also crystallize naphthalmostat mesylate.

3. Glucose injection for dissolving drugs: Glucose is easily dehydrated to form 5-HMF under certain conditions, and 5-HMF is an anion. When the content is high, it will react with NM to form an insoluble substance visible to the naked eye. Glucose formation of 5-HMF usually occurs in the following stages: production of raw materials, sterilization of preparations, and storage of preparations. Glucose raw material is hydrolyzed from starch, which may dehydrate part of the glucose during production to form 5-HMF. In the process of preparation sterilization, both the sterilization temperature and heating time affected the content of 5-HMF. The higher the temperature, the longer the heating time, the higher the content of 5-HMF. At the storage stage of the preparation, glucose injection is also prone to yellows, which is because with the extension of storage time, glucose is gradually dehydrated into 5-HMF in the acidic solution, and it should be preserved under dark light, because light also accelerates the decomposition of glucose.

4. Syringe reason: silicone oil is usually added to the syringe to reduce pushing resistance. When the amount of silicone oil is too much, the mixing of silicone oil and napathat mesylate will produce turbidity.

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