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05
Sep, 2024
Nano-PSO Administration Attenuates Cognitive And Neuronal Deficits Resulting ...
Abstract: Traumatic Brain Injury (TBI), is one of the most common causes of neurological damage in young populations. It is widely considered a risk factor for neurodegenerative diseases, such as A...
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05
Sep, 2024
Prion Protein: The Molecule Of Many Forms And Faces Part 3
Based on the determined oligomer binding domains, researchers have designed potential treatment strategies for AD based on synthetic peptides [204,223] and functional Aβ oligomer-binding compounds ...
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05
Sep, 2024
Prion Protein: The Molecule Of Many Forms And Faces Part 2
5. Prion Protein and Ischemic Strokes In the previous section, we observed that knockout animals are more vulnerable to oxidative stress. Studies support the idea that PrPC acts as an antioxidant b...
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04
Sep, 2024
Prion Protein: The Molecule Of Many Forms And Faces Part 1
Abstract: Cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored protein most abundantly found in the outer membrane of neurons. Due to structural characteristics (a flexibl...
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04
Sep, 2024
Neuropsychological Test Performances And Depression in Early-Stage De Novo Pa...
Abstract Objective: Evaluate neuropsychological test performance in depressed patients with early-stage Parkinson's disease. The relationship between early Parkinson's disease and memory is a t...
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04
Sep, 2024
Monoclonal Antibodies As Neurological Therapeutics Part 5
7.2. Anaphylactic Reactions True anaphylactic reactions require the development of anti-mAb antibodies of the IgE isotype. We all know that allergic reactions can cause uncomfortable symptoms, such...
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03
Sep, 2024
Monoclonal Antibodies As Neurological Therapeutics Part 4
6.6. Immune-Mediated Peripheral Neuropathies Rituximab has been tried in several peripheral neuropathies, which are thought to be antibody-mediated and do not respond to the administration of intra...
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03
Sep, 2024
Monoclonal Antibodies As Neurological Therapeutics Part 3
Inebilizumab is a humanized mAb targeting CD19 which is expressed on a wider lineage of B cells, including early pro-B cells, and persisting through maturation to some short-lived plasmablasts and ...
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03
Sep, 2024
Monoclonal Antibodies As Neurological Therapeutics Part 2
4.2. Indirect or Immune-Mediated Actions Conserved differences in the constant regions (Fc) of IgG antibodies distinguish them into four subclasses: IgG1, IgG2, IgG3, and IgG4 [158,159]. Conservati...
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02
Sep, 2024
Monoclonal Antibodies As Neurological Therapeutics Part 1
Abstract: Over the last 30 years, the role of monoclonal antibodies in therapeutics has increased enormously, revolutionizing treatment in most medical specialties, including neurology. In recent y...
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02
Sep, 2024
Neuroprotective Benefits Of Exercise And MitoQ On Memory Function, Mitochondr...
3.4. Effect of Treadmill Exercise and MitoQ on the Expression of Inflammatory Proteins and Antioxidant Enzymes in the Hippocampus of D-Gal-Induced Aging Rats TE and MitoQ were confirmed to affect i...
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02
Sep, 2024
Neuroprotective Benefits Of Exercise And MitoQ On Memory Function, Mitochondr...
2.6. Tissue Preparation After completing 8 weeks of TE and memory behavior tests, all rats were euthanized by CO2 inhalation, and brain tissues were harvested from 7 animals in each treatment group...
