Cistanche tubulosa extract orally administered at 26.4 g/kg to male and female mice and kept for 8 days caused no abnormalities, fatal events, or autopsy abnormalities. No issues were observed when dosing 0.65-1.30 g/kg cistanche daily for 30 days to rats.

OEM tablets cistanche tubulosa ginseng astragalus extract Mixed powder

Examining potential long-term toxicity, Cistanche tubulosa extract was orally administered to male and female rats at 1.65 g/kg per day and kept for 180 days. No abnormalities, fatal events, or autopsy abnormalities were recorded.

Furthermore, no abnormalities, fatal events, or autopsy abnormalities were observed when a Cistanche tubulosa extract was orally administered to male and female beagle dogs at 1.50 g/kg daily and kept for 180 days.

This data was collected by Oryza Oil & Fat Company out of Japan, and when converted to Human Equivalent Doses (HED) based on body surface area we arrive at the following dosages:

• 2.15 g/kg Cistanche HED - acute toxicity study (mice)

• 0.85 g/kg Cistanche HED - 180 day toxicity study (dogs)

• 0.25 g/kg Cistanche HED - 180 day toxicity study (rats)

• When multiplied by individual bodyweight, the human equivalent dose for a person is very large at 10+ grams, an amount that far exceeds the typical dosing recommendations, and therefore is not recommended to try but does give confidence that cistanche has a strong safety profile with very little chance of negative side effects occurring at the much lower dosages recommended.
  

In terms of practical side effects that may be experienced, a large dose may cause digestive discomfort and since cistanche increases testosterone levels, it may cause alterations to mood and aggression. Additionally, cistanche as a vaso-relaxant reduces blood pressure and should not be taken if an individual’s blood pressure is already on the low side (<80/60).

If you have any questions about cistanche, our professional team will answer any confusion

wallence.suen@wecistanche.com