April 11 World Parkinson's Day, Care For Parkinson's Patients!

April 11 every year is World Parkinson's Disease Day. According to statistics, there are about 4.5 million Parkinson's disease patients in the world, nearly half of them in China. There are currently 2.6 million Parkinson's disease patients in China. About 1.7% of the elderly population over the age of 65 in my country suffers from Parkinson's disease, and the prevalence rate is 3%-5% over the age of 70. It is the "third killer" of middle-aged and elderly people after tumors and cardiovascular and cerebrovascular diseases. , and there are nearly 100,000 new cases every year. Experts from the World Health Organization predict that the number of Parkinson's disease patients in China will reach 5 million in 2030. At present, Parkinson's disease patients are becoming younger, and "juvenile Parkinson's disease" patients account for 10% of the total number.

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Parkinson's disease is a common chronic degenerative neurological disease. It is difficult to detect, easy to be ignored, or misdiagnosed. We often see Parkinson's patients with tremor symptoms in film and television dramas. In fact, Parkinson's disease is not only a "shaking" symptom, "shaking" is actually just one of the motor symptoms of Parkinson's disease, and Parkinson's disease has two types non-motor symptoms and motor symptoms.

Non-motor symptoms of Parkinson's disease:

1. Decreased or absent sense of smell

 Although hyposmia is not present in every patient with Parkinson's disease, its presence or development may be a specific marker before the onset of motor symptoms in patients with early Parkinson's disease.

2. Anxiety and Depression

 Anxiety and depression are also clinically prevalent, and as with olfactory disorders, anxiety can precede motor symptoms.

3. Sleep disorders

 Sleep disturbance in patients with Parkinson's disease increases with the duration of the disease, and sleep disturbance may be related to the pathology of the disease, but the effect of dopamine drug treatment is minimal.

4. Autonomic dysfunction

 Symptoms of autonomic dysfunction include bladder sphincter dysfunction, gastrointestinal dysfunction, abnormal cardiovascular function, hyperhidrosis, constipation, etc., and may also appear before motor symptoms.

Parkinson's motor symptoms:

1. Tremor

 Early tremors are not typical, and most of them are only small tremors during the excitement and mental tension, without typical “rubbing pill-like” movements, and are related to emotions and attention.

2. Myotonia

 In the early stage, limb stiffness occurs, and the wrist joint is more or less straight, which is called the "road sign phenomenon".

3. Move slowly

 Slow and clumsy movements, reduced facial expressions and blinking, smaller and smaller handwriting, broken steps when walking, reduced arm swings and amplitude, slower speech, lower pitch, slower speed, and reduced amplitude when doing fast repetitive movements Small.

4. Postural balance disorder

 The early symptoms of the disease are abnormal gait, such as the reduction of the swing of the upper limbs, the reduction of the number of times, the dragging of the lower limbs, and sometimes the whole body freezes during walking, which is called "freezing" phenomenon. At the same time, it is difficult to start and turn around, and the pace is in a forward rush state, and it cannot stop in time.

Parkinson's patients Going to the doctor in a panic, being deceived by some so-called new technologies!

Every patient suffering from Parkinson's will be very afraid, afraid, especially when the doctor has finished saying that the disease cannot be cured, and many people are extremely desperate. Some patients have been treated for a long time without getting better, but instead, If it aggravates, the heart will be extremely anxious, and then I will think wildly. At this time, many liars will take advantage of the patient's psychology to use some specious "new technologies, and what kind of folk earthwork to cure them. These so-called new treatments, new technologies It is characterized by hype, self-made, exclusive, and other fashionable words, such as cell regeneration, nerve repair, etc. There is no cure for Parkinson's disease in the world. Patients should not be misled by some small advertisements and take remedies rashly, health care products, not only delays the disease but also wastes money. Regular medical institutions do not have this practice, so we must pay attention to distinguish the qualifications of medical institutions. A correct treatment method is directly related to the development of the patient's disease! Although the current treatment of Parkinson's It has always been a difficult problem in the medical field, the traditional Chinese medicine method; Cistanche tubulosa Extract can achieve a very good inhibitory effect!

The monomer compound campneoside II in Cistanche has obvious cytoprotective effects on cerebellar granule cell apoptosis in patients with Parkinson's disease. Tubuloside B has a good inhibitory effect on brain cell apoptosis and anti-oxidative stress in patients with Parkinson's disease. This compound may be used in the treatment of Parkinson's disease.

Acteoside in Cistanche can significantly improve the behavioral performance of patients with Parkinson's disease, increase the content of dopamine transmitters and the number of dopaminergic neurons, and the level of a-synuclein protein in the substantia nigra striatum. Verbascum glycosides can induce SH in rotenone -SY5Y cell injury has a neuroprotective effect, and its mechanism of action is related to reducing the degradation of Parkinson’s disease-related proteins and inhibiting the formation of α-synuclein dimers; verbascoside can reduce the SH-SY5Y injury induced by the neurotoxin MPP+ The level of reactive oxygen species, increase the expression level of Bcl-2, and reduce the activity of caspase-3 indicate that the compound can effectively inhibit the apoptosis of SH-SY5Y cells. The mechanism of action is to reduce the level of intracellular reactive oxygen species and inhibit caspase-3. Activity is related to maintaining the high-energy state of mitochondrial membrane potential; verbascoside can also have obvious cytoprotective effects on brain cell apoptosis in patients with Parkinson's disease, and can effectively resist Parkinson's disease.

For more information:ali.ma@wecistanche.com