Chronic Constipation Linked To Higher Risk Of Cognitive Decline
Nov 28, 2023
New research finds that constipation may be linked to worsening cognitive function. There are three prospective studies, with more than 100,000 participants, linking chronic constipation (three or more days between bowel movements) to cognitive decline.
Compared with people who had daily bowel movements, researchers found that people with chronic constipation had a 73% higher risk of cognitive decline—the equivalent of three additional years of cognitive aging. The research, presented at the Alzheimer's Association International Conference, is part of a growing body of evidence linking a person's gut microbiome to their brain health. Researchers say the buildup of harmful bacteria in the gut may be an underlying cause of cognitive decline.
Constipation may be one of many factors that prompt clinicians to further evaluate and monitor a person's cognitive health—even if it does not unequivocally predict cognitive decline.
Early detection of changes in bowel habits may lead to earlier intervention or lifestyle changes, which may impact overall health, including cognitive function.
How constipation affects brain health
Approximately 16% of people worldwide struggle with constipation, which is more common among adults. This phenomenon is mainly due to age-related factors such as lack of exercise and insufficient dietary fiber intake. Even the use of certain medications can increase the likelihood of constipation. But how does this affect brain health?
Historically, chronic constipation has been associated with inflammation and mood disorders, such as anxiety and depression. So it's not surprising that the new study suggests it may also be linked to cognitive function — although its exact role in brain health is unclear.
Of note, this study did not show a cause-and-effect relationship between constipation and cognitive function, only a correlation. That said, the connection between the two is worth considering when thinking about long-term health.
You wouldn't typically think of your gut health as directly affecting your brain health, but current research suggests there is a link.
One of your main cranial nerves—your vagus nerve—connects your digestive tract to your brain.
Researchers speculate that the link between constipation and cognitive decline may be related to the bacteria in the gut—some of which are protective and some of which are not.
Those who have infrequent bowel movements and cognitive decline show depletion of good bacteria that produce butyrate, or fatty acids that support the intestinal barrier and prevent bacteria and other microorganisms from entering the bloodstream.
Those with chronic constipation may have more bacteria that cause inflammation and fewer bacteria that help break down certain dietary fibers. It is important to address the symptoms of constipation to avoid any long-term consequences associated with ongoing inflammation and chronic disease.
Currently, the biggest unknown is whether neurological diseases like Alzheimer's cause bacterial changes in the gut, or whether bacterial changes in the gut (from constipation) are the cause of neurological disease. Correlation is a little different from causation. Constipation and digestive problems may be ways this disease manifests itself.
"[But] if someone has digestive issues, neurological issues aren't the first thing we think of," On the other hand, sometimes digestive issues can be the first sign that something is wrong, especially constipation.
While constipation is a common symptom that cannot be definitively said to be an early indicator of Alzheimer's disease, this research may help clinicians move forward, particularly regarding the link between gut bacteria and brain health.
The brain-gut axis is an important communication pathway between the gut and the central nervous system. This two-way communication [system] involves various biochemical signaling, neural pathways, and the gut microbiome.
Researchers are learning more about the role of the gut microbiome in different stages of Alzheimer's disease. This study of the gut-brain axis may help detect and prevent memory loss in new ways.
Although gut bacteria are not currently used as a screening tool, in the future doctors and researchers may be able to identify certain bad bacteria and address possible cognitive decline before they become a problem.
Prevent constipation and promote brain health
Although constipation doesn't guarantee you'll develop cognitive problems as you age, this study suggests it may increase your risk. Therefore, it is important to address constipation before it becomes a problem.
There are many things we already know are healthy for our brains and can improve constipation. So that justifies even more why we do the things we do.
First, prioritize hydration. It is recommended to drink at least 64 ounces (1800-1900ml) of water per day, or half your body weight in ounces.
You can also experiment with the amount of fiber you eat. While some people thrive on a high-fiber diet, others need much lower daily fiber to have regular bowel movements.
Prebiotic and probiotic supplements are another option for preventing constipation.
Magnesium glycinate has also worked wonders for many people. You need 300 mg to 400 mg. If that doesn't seem to be working, try pelvic floor physical therapy.
You should also address your nutritional concerns. For example, eating a healthy diet, such as the Mediterranean diet, which focuses on plant-based foods, has been linked to preventing dementia.
Performing aerobic exercise also helps increase blood flow throughout the body. Exercise stimulates muscle contractions to help pass stool more easily.
You should also get enough sleep and reduce stress. This method not only prevents constipation but also promotes brain health.
Natural Herbal Medicine For Relieving Constipation-Cistanche
Cistanche is a genus of parasitic plants that belongs to the family Orobanchaceae. These plants are known for their medicinal properties and have been used in Traditional Chinese Medicine (TCM) for centuries. Cistanche species are predominantly found in arid and desert regions of China, Mongolia, and other parts of Central Asia. Cistanche plants are characterized by their fleshy, yellowish stems and are highly valued for their potential health benefits. In TCM, Cistanche is believed to have tonic properties and is commonly used to nourish the kidney, enhance vitality, and support sexual function. It is also used to address issues related to aging, fatigue, and overall well-being. While Cistanche has a long history of use in traditional medicine, scientific research on its efficacy and safety is ongoing and limited. However, it is known to contain various bioactive compounds such as phenylethanoid glycosides, iridoids, lignans, and polysaccharides, which may contribute to its medicinal effects.
Wecistanche's cistanche powder, cistanche tablets, cistanche capsules, and other products are developed using desert cistanche as raw materials, all of which have a good effect on relieving constipation. The specific mechanism is as follows: Cistanche is believed to have potential benefits for relieving constipation based on its traditional use and certain compounds it contains. While scientific research specifically on Cistanche's effect on constipation is limited, it is thought to have multiple mechanisms that may contribute to its potential to relieve constipation. Laxative Effect: Cistanche has long been used in Traditional Chinese Medicine as a remedy for constipation. It is believed to have a mild laxative effect, which can help promote bowel movements and induce constipation. This effect may be attributed to various compounds in Cistanche, such as phenylethanoid glycosides and polysaccharides. Moistening the Intestines: Based on traditional use, Cistanche is considered to have moisturizing properties, specifically targeting the Intestines. Promoting hydration and lubrication of the Intestines, may help soften tools and facilitate easier passage, thereby relieving constipation. Anti-inflammatory Effect: Constipation can sometimes be associated with inflammation in the digestive tract. Cistanche contains certain compounds, including phenylethanoid glycosides and lignans, that are believed to have anti-inflammatory properties. By reducing inflammation in the intestines, it may help improve bowel movement regularity and relieve constipation.
