The mechanism of Amantadine treating Parkinson's disease

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Acetylcholine is also one of many chemical transmitters in the brain, and it is more abundant in the striatum of the brain. Like dopaminergic neurons, neurons that release the acetylcholine neurotransmitter when nerve cells are excited are called cholinergic neurons. A balance is maintained between dopamine and acetylcholine in the brain. There is a mutually inhibitory relationship between these two chemical transmitters and the corresponding nerve cells. Dopamine can inhibit cholinergic nerve cells. The content of acetylcholine in the brain tissue of patients with Parkinson's disease is normal, but because the content of dopamine decreases, the inhibitory effect on cholinergic neurons is weakened, and the function of cholinergic neurons is relatively hyperactive, causing some symptoms. Symptoms of Parkinson's disease. Therefore, drugs that inhibit the action of acetylcholine can relieve the patient's symptoms. At present, there are a large number of anticholinergic drugs in clinical practice, some of which can be used to treat Parkinson's disease. Generally speaking, these drugs can reduce the symptoms of Parkinson's disease by 20% to 25%, and the effect of tremors is better. The commonly used drug in China is Antan.

Treat Parkinson's disease: amantadine & cistanches herbal medicine

Amantadine can partially improve the symptoms of Parkinson's disease, especially in the early stage. Recent studies have also found that it has some effect on some of the late symptoms of Parkinson's disease, such as motor fluctuations. But until now, the mechanism by which amantadine can alleviate the symptoms of Parkinson's disease is not very clear. Antagonists of some harmful excitatory amino acids, etc.

Treat Parkinson's disease: Cistanche Tubulosa & amantadine

The specification of amantadine in my country is 100mg white tablets, and the general dosage is one tablet each time, 2 to 3 times a day. The curative effect of amantadine is that it often loses its curative effect after half a year to one year of use, but the curative effect will recover again after the drug is stopped for a period of time and then resumed. This is a very interesting phenomenon. We can take advantage of this feature. After using amantadine for several months, we can try to stop the drug for about a week. If there is no change in the condition, it is not necessary to continue taking it at this time. It can be completely Stopped taking the medicine and resume taking it after one to two months. If the patient's condition worsens after stopping the drug, it indicates that the drug is taking effect and should be resumed immediately.

amantadine and cistanche reduce symptoms of Parkinson's disease

Its side effects are similar to those of anticholinergic drugs, including blurred vision, constipation, dry mouth, mental illusion, etc., but the degree is very mild.

sistanch is cistanche