How Is The Efficacy Of Chinese Medicine For Replenishing Kidney in Treating Nephropathy Manifested in Clinical Practice?
Mar 07, 2022
Studies on the biological activity of the active ingredients have shown that the contained amino acids, alkaloids, and flavonoids have the effects of anti-virus, promoting the formation of antibodies, and prolonging the survival of cells in vitro. In vitro experiments proved that oral or intravenous drip of astragalus decoction has a certain protective effect on mice infected with type I parainfluenza virus. Astragalus can induce the body to produce interferon, increase the sensitivity of cells to interferon, and strengthen the antiviral ability. Astragalus can also reduce the titer of hepatitis B surface antigen (HBsAg) or make it negative. It can be used for all types of hepatitis patients. It is especially suitable for patients with chronic persistent hepatitis (CPH) and chronic active hepatitis (CAH) with low cellular immune function. Clinical application of Huangqi Zhuanyin Recipe (30g each of Astragalus, Yinchuan, 20g each of Astragalus, Salvia, Radix Paeoniae Rubra, 20g each of Radix Isatidis, 10g each of Atractylodes, Polygonatum, Xianling Spleen, Polygonum cuspidatum, Forsythia, Polyporus 5g, Licorice 5g) Treat viral hepatitis.
In terms of liver fibrosis, in-depth studies have found that the extracellular matrix that increases when liver fibrosis occurs is mostly typed Ⅰ, type Ⅲ collagen. In the early stage of liver fibrosis, type Ⅲ collagen is mainly increased. In the late stage of liver fibrosis, type Ⅰ Collagen is mainly increased and mainly deposited in the Disse cavity, while hepatic stellate cells are the main cells that differentiate collagen during liver fibrosis. At present, the treatment of liver fibrosis is an important means to prevent the development of chronic liver disease into cirrhosis. Finding effective anti-liver fibrosis drugs is a research hotspot. Among the many anti-hepatic fibrosis drugs, Astragalus and its compound are a kind of drug with great potential for development. Whether in animal experiments, clinical experiments, or experiments on hepatic stellate cells, it has been found to have anti-liver fibrosis effects. For example, Wang Yaojun et al. [8] observed the influence of astragalus on the expression of intercellular adhesion molecule-1 (ICAM-1) in experimental liver fibrosis tissues. The expression of ICAM-1 in liver cells is related. In clinical research, Cao Wenyi et al. [9] found that astragalus compound decoction can significantly improve the hemodynamic parameters of patients with liver fibrosis, prevent the occurrence of complications, and delay the development of the disease. Cheng Peng et al. [10] observed the effect of Astragalus injection on serum TGF-β1 HA in patients with chronic hepatitis and found that the serum TGF-β1-HA levels before and after treatment with Astragalus injection were higher than those in the control group. Serum indicators of fibrosis. Clinically, Astragalus is used in combination with Salvia miltiorrhiza, peach kernels, tetrandrine, Panax notoginseng, Turtles, oysters, Rehmannia glutinosa, Bupleurum, Scutellaria baicalensis Georgi, Zhabei, Jujube, and Astragalus is used as the monarch drug to be added or subtracted according to the syndrome.
Conclusion:
At present, China is a country with a high incidence of hepatitis. Improving the cure rate of hepatitis and preventing the development of chronic hepatitis, liver cirrhosis and liver cancer are key issues in the medical field. In the treatment of hepatitis and liver cirrhosis, TCM has great advantages and prospects. TCM clinical syndrome differentiation and treatment can regulate the human body as a whole. The various effects of the traditional Chinese medicine Astragalus and its compound play a role in the treatment at the same time, which improves the clinical efficacy. It is worthy of further research and application promotion.
Abstract:
Objective To explore the therapeutic effect of Chinese medicine for replenishing the kidney in the treatment of nephrotic syndrome.
Methods:
With reference to recent literature, the clinical application of kidney-tonifying Chinese medicines in nephrotic syndrome was reviewed. Results Yishen Chinese medicine can improve the hypercoagulable state of nephrotic syndrome blood, improve the body's antioxidant capacity, reduce the leakage of urine protein, and is also of great significance in preventing and treating thrombosis.
Conclusion:
Chinese medicine for replenishing the kidney can be used as one of the drugs for adjuvant treatment of nephrotic syndrome.
Keywords:
Chinese medicine for tonifying the kidney; nephrotic syndrome; clinical application
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Nephrotic syndrome (NS) is a clinical syndrome in which the increased permeability of glomerular capillaries caused by various causes leads to large amounts of proteinuria. The etiology is unknown, and the detailed pathogenesis is unclear. Patients with NS have a hypercoagulable state. From the current clinical application, Chinese medicine for tonifying the kidney has shown a good adjuvant treatment effect on nephrotic syndrome. The clinical application of it in nephrotic syndrome is summarized as follows.
1 Astragalus injection in the treatment of the nephrotic syndrome
Astragalus injection can improve lipid metabolism disorders, effectively reduce the activation of platelets, reduce platelet aggregation, improve microcirculation, improve blood hypercoagulability, and protect kidney function. It has been reported that 32 cases of nephrotic syndrome patients were treated with Huangqi injection. As a result, 17 cases were completely relieved in the treatment group, 11 cases were basically relieved, 4 cases were ineffective, and the total effective rate was 87.5%; while the 12 cases in the control group, 3 cases were completely relieved, 2 cases were basically relieved, 7 cases were ineffective, and the total effective rate was 41.7%. The curative effect of the treatment group was significantly higher than that of the control group (P <0.01). Treatment method: In the treatment group, use 20ml of Huangqi injection plus 250ml of 10% glucose injection by intravenous drip once per day, 15 days as a course of treatment, except for general symptomatic treatment, without any anticoagulant drugs; the control group is generally treated the same as the treatment group ‚And routinely give aspirin 50mg, once a day, the course of treatment is 15 days.
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2 Low molecular weight heparin combined with astragalus for treatment of the refractory nephrotic syndrome
Li Ruqin et al. [4] randomly divided 65 patients with refractory nephrotic syndrome into two groups. The control group received conventional treatment. The treatment group was treated with low-molecular-weight heparin and astragalus injection on the basis of conventional treatment, followed by observation of curative effect. The effects of low-molecular-weight heparin and astragalus on renal function and blood coagulation were evaluated by laboratory tests. Results: Comparing the efficacy of the two groups, the treatment group was significantly better than the control group (P<0.05); its serum protein, urine protein, white blood cell count, and other laboratory test indicators, the treatment group was significantly different from before treatment (P ＜0.05) ‚Compared with the control group after treatment, there is also a statistical difference (P＜0.05), and its curative effect is related to the pathological type. Conclusion: Low molecular weight heparin and astragalus injection can reduce the hypercoagulable state of the blood, and the combined application has a significant effect on the treatment of the refractory nephrotic syndrome.
3 Treatment of primary nephrotic syndrome with heparin, astragalus injection, and captopril
The 60 hospitalized patients with primary nephrotic syndrome were divided into a treatment group and a control group with 30 cases each. The remission and complications after treatment were observed respectively. The results showed that the two groups had significant differences in urinary protein quantitative indicators (P <0.05) There were significant differences in infection recurrence and clinical cure between the two groups after the Chi-square test (P <0.05). Recurrence rate: 20% in the treatment group and 53.3% in the control group; cure rate: 80% in the treatment group and 56.7% in the control group; compared with the treatment group, the control group has a longer course of the disease, more complications, and higher recurrence rates. Conclusion: Heparin anticoagulation therapy combined with Huangqi injection and captopril in the treatment of primary nephrotic syndrome can significantly improve blood hypercoagulability, lower blood cholesterol, reduce kidney damage, and promote the early remission of primary nephrotic syndrome. Reduce recurrence.
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4 Leonurus injection in the treatment of refractory nephrotic syndrome in children
Nephrotic syndrome can cause the body's coagulation, anticoagulation, and fibrinolytic system components to be disordered. Platelet function is abnormal, blood viscosity increases, and the first choice for hypercoagulable nephropathy is prednisone. But in the process of long-term large-scale treatment, it can also promote a Hypercoagulable state of the blood. Modern pharmacological studies believe that Motherwort has many effects such as thrombolysis, anticoagulation, lipid-lowering, lowering blood viscosity, reducing red blood cell aggregation, inhibiting platelet aggregation, improving microcirculation, anti-free radicals, and reducing intracellular calcium overload. Zong Xin et al [6] randomly divided 41 children with refractory nephrotic syndrome with hypercoagulable state into treatment group and control group, and were treated with hormones and immunosuppressive agents. 21 cases in the treatment group were treated with Leonurus injection for anticoagulation; 20 cases in the control group were treated with dipyridamole orally.
Results: The curative effect of the treatment group was significantly better than that of the control group (P<0.01).
Conclusion: Motherwort injection is safe and effective in the treatment of refractory nephrotic syndrome with a hypercoagulable state, and its curative effect is better than that of the control group.
5 Shenmai injection in the treatment of hemorrhagic fever with nephrotic syndrome
The combination of traditional Chinese and western medicine has obvious effects in the treatment of hemorrhagic fever with nephrotic syndrome. It has been reported [7] 60 cases of hemorrhagic fever with nephrotic syndrome were treated with Shenmai injection on the basis of conventional treatment. The results showed that the addition of Shenmai injection in the treatment of hemorrhagic fever with nephrotic syndrome can reduce the fever quickly, the renal function damage is light and the recovery is quick, the urine protein disappears early, the complications are less, and it can promote the recovery of the disease.
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6 Compound Danshen Injection Treats Nephrotic Syndrome
Liu Haiqing et al. [8] used compound Danshen injection 20ml astragalus 20ml added 5% glucose injection 250ml by intravenous drip 1 time/d while taking prednisone 1mg/kg presenting 75mg/d orally in 3 doses, and the control group did not need the compound Danshen injection, astragalus. Treatment of 42 patients with primary nephrotic syndrome. After two weeks of treatment, it effectively increased plasma protein and reduced urine protein content. Compared with the control group, P<0.01, while reducing triglycerides and cholesterol compared with the control group. P<0 .05‚It can reduce symptoms such as edema and prevent and treat various complications.
7 Chinese wolfberry, Shouwu, hawthorn, salvia, Morinda Officinalis, Cistanche, etc. to treat nephrotic syndrome
Kidney disease is a common disease in pediatrics, and its exact pathogenesis is not yet clear. A large number of studies have confirmed that factors such as reactive oxygen free radicals and blood hypercoagulable states play a very important role in its occurrence and development. To effectively control the condition of nephropathy, improve the body’s antioxidant capacity, and reduce lipid peroxidation damage, Chinese medicines for invigorating the kidney and promoting blood circulation, wolfberry, shows, hawthorn, salvia miltiorrhiza, Morinda cistanche, and Cistanche, can be used to treat nephropathy, which can increase SOD activity and reduce LPO. The content effectively reduces peroxide damage. The possible mechanisms of action are ① Morinda officinalis and Cistanche to nourish kidney yang; Lycium barbarum and Shouwu nourish kidney yin; Hawthorn and Danshen promote blood circulation and reduce blood stasis, reduce blood lipids, resist platelet aggregation, and improve microcirculation. This prescription may reduce lipid peroxidation damage by strengthening the body's resistance and improving microcirculation, thereby weakening the interaction between free radicals and blood stasis. ②Increase the activity of SOD in the body, inhibit lipid peroxidation, reduce the accumulation of lipid peroxidation products in the body, reduce glomerular immune damage, prevent a large amount of protein from being lost in the urine, and delay the pathological process of the kidney. Through this study, it is suggested that Chinese medicine for tonifying the kidney and promoting blood circulation can improve the body's antioxidant capacity, reduce lipid peroxidation damage, reduce the leakage of urine protein, improve the effective rate of treatment, and have certain clinical significance in the prevention and treatment of nephropathy.
References:
[1] Liang Muxing, Huang Songyin, Lin Xianghua, etc. The clinical value of blood coagulation and platelet parameter testing in patients with nephrotic syndrome [J]. Journal of Modern Clinical Medical Bioengineering, 2002, 8(3): 213. [2] Song Shanlu, Fang Qin, Guo Yiqing, etc. Clinical analysis of 26 cases of nephrotic syndrome with the hypercoagulable state before and after treatment [J]. Journal of Practical Pediatrics and Clinical Medicine, 2002, 17(6):661. [3] Li Wenzhi, Song Fuyun, Zou Shizong. The clinical application of Huangqi injection [J]. China Pharmaceuticals‚ 2004‚13(7):81. [4] Li Ruqin, Li Zhongshan, Liu Guan Chang, etc. A clinical study on the treatment of refractory nephrotic syndrome with a combination of low molecular weight heparin and astragalus [J]. Chinese Journal of Integrated Traditional Chinese and Western Medicine on Nephropathy, 2005, 6(2): 92. [5] Li Shaoxia, Zhong Sue, Huang Hanzhong, etc. A clinical controlled study of heparin, astragalus injection, and captopril in the treatment of primary nephrotic syndrome [J]. International Medicine & Health Guidance News‚ 2006‚ 12 (9): 28. [6] Zong Xin, Zhao Zhongfang, Meng Qingping. The clinical study of Motherwort injection in the treatment of refractory nephropathy syndrome in children with hypercoagulable state [J]. Shandong Journal of Traditional Chinese Medicine‚2003‚22(8):456. [7] Lv Aiqin, Yan Shuangyin, Wang Lifang, etc. Clinical application progress of Shenmai injection [J]. Tianjin Medicine‚2004‚16(4):34. [8] Liu Haiqing, Hao Jinhua, Li Zhiqiang, etc. The effect of Fufangdan in the treatment of nephrotic syndrome with astragalus
