Malnutrition Patterns in Children With Chronic Kidney Disease Part 3
Oct 23, 2023
Why we will be tired? How can we solve the fatigue problems?
【Contact】Email: george.deng@wecistanche.com / WhatsApp:008613632399501/Wechat:13632399501
11. Conclusions
Children with CKD are susceptible to both undernutrition/PEW and overnutrition/obesity patterns of malnutrition. Both conditions may ultimately imperil renal function and cardiovascular health. The risk for high adiposity in patients with normal BMI and the growing prevalence of muscle wasting in both PEW and obese conditions indicate the need for body composition assessment. Application of anthropometric techniques is, in general, discouraged due to the lack of precision and the high inter- and intra-observer variability. Several technological tools are used in clinical practice and regardless of their limitations, they could be proven efficient for body composition monitoring. Further studies are needed to evaluate the benefits of regular body composition monitoring in everyday clinical practice. Moreover, apart from nutritional management, early-onset rGH therapy in case of growth failure and the application of exercise training tailored to the patient's needs may help to improve muscle mass and strength and in parallel reduce the risk of fat mass accumulation.
Cistanche can act as an anti-fatigue and stamina enhancer, and experimental studies have shown that the decoction of Cistanche tubulosa could effectively protect the liver hepatocytes and endothelial cells damaged in weight-bearing swimming mice, upregulate the expression of NOS3, and promote hepatic glycogen synthesis, thus exerting anti-fatigue efficacy. Phenylethanoid glycoside-rich Cistanche tubulosa extract could significantly reduce the serum creatine kinase, lactate dehydrogenase, and lactate levels, and increase the hemoglobin (HB) and glucose levels in ICR mice, and this could play an anti-fatigue role by decreasing the muscle damage and delaying the lactic acid enrichment for energy storage in mice. Compound Cistanche Tubulosa Tablets significantly prolonged the weight-bearing swimming time, increased the hepatic glycogen reserve, and decreased the serum urea level after exercise in mice, showing its anti-fatigue effect. The decoction of Cistanchis can improve endurance and accelerate the elimination of fatigue in exercising mice, and can also reduce the elevation of serum creatine kinase after load exercise and keep the ultrastructure of skeletal muscle of mice normal after exercise, which indicates that it has the effects of enhancing physical strength and anti-fatigue. Cistanchis also significantly prolonged the survival time of nitrite-poisoned mice and enhanced the tolerance against hypoxia and fatigue.
Click on Over fatigue
Funding: This research received no external funding.
Institutional Review Board Statement: Not applicable.
Informed Consent Statement: Not applicable.
Data Availability Statement: Not applicable.
Conflicts of Interest: The authors declare no conflict of interest
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