Research On The Status Quo And Development Strategy Of Traditional Chinese Medicine Pharmaceutical Equipment Industry Ⅱ
Dec 12, 2022
3 Research on key research and development strategies of traditional Chinese medicine pharmaceutical equipment industry
3.1 Intelligent upgrade of processing equipment in the origin of traditional Chinese medicinal materials
3.1.1 Intelligent linkage line equipment for traditional Chinese medicinal materials processing
The intelligent linkage line equipment for the processing of traditional Chinese medicinal materials in the origin has made breakthroughs in key technologies such as the common technology, automatic control and linkage line control of the origin of traditional Chinese medicinal materials, and researched and developed the intelligent and informative special equipment for the processing of traditional Chinese medicinal materials in the origin, including the cleaning, cutting and drying linkage line equipment As well as the control system, it changes the traditional manual material transfer and stand-alone operation mode, improves the processing efficiency in the production area, and ensures the quality of Chinese herbal medicines.
Traditional Chinese medicinal materials
3.1.2 Development of vehicle-mounted processing equipment for traditional Chinese medicinal materials
The development of vehicle-mounted processing equipment for traditional Chinese medicinal materials refers to the research and development of common technologies for the processing of traditional Chinese medicinal materials, and the development of a series of vehicle-mounted mobile processing equipment for traditional Chinese medicinal materials, mainly including washing, moistening, cutting and drying linkage equipment and control systems, and special medicinal materials ( Fritillaria, antler,Cistanche, gastrodia elata, dendrobium,American ginseng, etc.) processing equipment, etc.
3.1.3 Modern drying technology and equipment development of Chinese medicinal materials
The development of modern drying technology and equipment for Chinese medicinal materials refers to the development of new drying technology equipment for Chinese medicinal materials that is energy-saving and environmentally friendly, has a wide range of applications, high production efficiency, convenient washing and cutting, high degree of automation, and meets the requirements of the new version of GMP, such as microwave drying equipment. , near-infrared drying equipment, etc., can have
It can effectively improve the drying efficiency and quality control level of Chinese herbal medicines[4].
3.2 Intelligent Processing Equipment and Technology of Chinese Herbal Pieces
3.2.1 Intelligent Chinese herbal medicine processing equipment and information control system In view of the backward technology of Chinese herbal medicine processing equipment, most of them are unit or stand-alone equipment, the level of automation is low, the application of modern information technology and control technology is lacking, and the production process monitoring cannot be realized. It is difficult to guarantee the stability and controllability of the quality of decoction pieces [5], and developed a series of intelligent processing equipment and information systems for decoction pieces of traditional Chinese medicine, including moistening machines, frying machines, broiling machines, cooking pots, and calcining furnaces Wait. Realize the standardization, automation, intelligence and informatization of the production process of Chinese herbal pieces, the production process can be controlled, the process parameters can be stored, and the quality of Chinese herbal pieces can be effectively controlled
3.2.2 Development of on-line control technology for processing equipment of traditional Chinese medicine decoction pieces
The research results of on-line control technology for the processing equipment of traditional Chinese medicine decoction pieces enable the key process parameters of the processing links such as cleaning, drying, crushing, infiltration, cooking and slicing to be accurately and effectively controlled, such as cleaning speed, cleaning pressure, drying temperature, crushing speed, infiltration temperature , immersion vacuum, steam
Pressure, cooking temperature, cooking time and slice thickness, slice rate, etc. The operation of the processing equipment is controlled by computer technology to ensure that the operating parameters of the processing process meet the process requirements [6].
3.2.3 Research on the equipment of the linkage line for the processing and processing of Chinese herbal decoction pieces
The processing and processing linkage line equipment of Chinese herbal decoction pieces integrates equipment manufacturing technology, automatic control technology and online detection technology, and develops a digital linkage production line of Chinese herbal decoction pieces processing unit equipment, which realizes automatic unpacking, vibration screening, dust removal, cleaning, infiltration, slicing, and drying , smash and pack
Assembly line production of the whole process [6]. Change the traditional manual material transfer and stand-alone operation mode, greatly improve the processing efficiency of decoction pieces and the stability of equipment operation, and establish processing technology specifications and standards for decoction pieces assembly line, build domestic leading processing technology and quality standards for decoction pieces of Chinese medicine, and essentially improve the decoction pieces of Chinese medicine quality and its stability.
3.2.4 The development of information management technology for the production of traditional Chinese medicine decoction pieces based on the Internet of Things
The production information management technology of traditional Chinese medicine decoction pieces adopts computer and automation technology, integrates configuration technology, sensor technology and radio frequency identification and other Internet of things technologies, innovatively designs intelligent controllable modules, and controls processing parameters online, collects quality inspection data, and combines Processing standard process, so as to realize paperless production task planning, standardization of processing process, objectification of process control, online production records and visualization of production process, and establish personalized, customized and coordinated manufacturing information management services based on the Internet platform to comprehensively improve the information management level of the production of traditional Chinese medicine decoction pieces [6].
3.3 Design and development of key process equipment in the extraction process of Chinese patent medicine
The design and research and development of key process equipment for the extraction process of Chinese patent medicines, fully refer to modern computer control technology, information technology and online detection technology, etc., for the key process links such as extraction, concentration, refining, and drying in the production process of Chinese patent medicines, develop and manufacture energy-saving, high-efficiency and Automated, modularized, informatized, intelligently controlled units/complete sets of equipment, online integrated production lines, and realize industrialization to improve the equipment level of my country's traditional Chinese medicine pharmaceutical industry.
3.3.1 Research and development of intelligent and low-energy unit equipment in the production process of Chinese patent medicine
The research and development of intelligent and low-energy unit equipment for the production process of Chinese patent medicine refers to the development of intelligent equipment for the production process of Chinese patent medicine with process quality control functions, including unit equipment such as extraction, concentration, alcohol precipitation, macroporous resin and alcohol recovery, and drying . On this basis, according to the characteristics of the unit process, a modularized automatic control system is developed. For example, extraction includes multi-functional extraction, countercurrent extraction and other processes, and separation and purification includes alcohol precipitation, water precipitation, flocculation, and adsorption processes. According to the characteristics of each process, the control system designs the corresponding control program and configuration in combination with the requirements of the process regulations and GMP regulations, so as to realize the online measurement and control of the process parameters of the unit process production process [7]. Establish energy consumption calculation methods for traditional Chinese medicine extraction equipment, concentration equipment, and alcohol precipitation equipment.
Energy consumption indicators are graded and marked to guide Chinese medicine companies to choose high-efficiency and energy-saving equipment to achieve goals such as reducing production energy consumption, improving production efficiency, and reducing production costs.
3.3.2 Research and development of intelligent production line for Chinese patent medicine extraction-concentration-drying process
The research and development of the intelligent production line of Chinese patent medicine extraction-concentration-drying process integrates automation control technology, process analysis technology, information management technology and big data mining technology, etc., to build Chinese patent medicine extraction automation, integrated linkage production line and information management technology, and establish The real-time release control strategy of the unit process realizes the release control of the whole process of extraction, concentration, purification, drying and solvent recovery, so that personnel, equipment, materials and products can operate according to the process and predetermined production procedures during the entire production process[8] . The information management system dominates the entire production process, realizes the storage, processing, statistical analysis and management of information data such as personnel, materials, equipment, energy, technology and quality, and mines and analyzes key process parameter information in the production process to achieve the same batch Traceability of drug production process information transmission and automatic comparison of different batches of drug production process information
Through comparative analysis, the safety production quality management and real-time controllability of the production process can be realized in the whole process from raw materials to finished product production[9-10].
3.4 Design and development of key equipment for Chinese patent medicine preparations
3.4.1 Traditional Chinese Medicine Whole Powder Direct Tablet Press
Combined with the research on the fluidity, compressibility and lubricity of the powder, the whole powder direct tablet press of traditional Chinese medicine breaks through the key points such as the fluidity and compressibility of the powder, the precision of the tablet weight, and the hardness of the tablet when the traditional Chinese medicine powder is directly compressed. technology to solve the complex process, long process, raw and auxiliary process in traditional tablet production
In order to solve the problems of large material loss, low production efficiency, high energy consumption and high risk of cross-contamination, we developed a new technology equipment for full powder direct tableting that directly compresses powder without granulation (wet granules or dry granules) into tablets. Improve the manufacturing level of Chinese traditional medicine tablets [11].
3.4.2 Tablet technology and equipment of traditional Chinese medicine pellets
Combined with the research on the technology, process and equipment of Chinese medicine pellets, the research focus of Chinese medicine pellets technology and equipment has broken through the traditional Chinese medicine pellets, which can still maintain its inherent drug release characteristics and keep the tableting pressure constant. In order to avoid large intra-batch variance and prevent slight
Key technologies such as pellet shedding and avoiding pellet delamination due to vibration in the tableting process, and development of technology and equipment suitable for tableting of traditional Chinese medicine pellets [12].
3.4.3 New type traditional Chinese medicine paste refining machine
The research focus of the new type of traditional Chinese medicine ointment machine breaks through key technologies such as manual or semi-mechanized operation of traditional Chinese medicine ointment production, qualitative control of the processing process, unstable product quality, and smoke emission from ointment production, and transforms the operating experience of old pharmaceutical workers into quantitative and controllable According to the technological parameters and quality standards, a new type of traditional Chinese medicine plaster refining machine is developed to promote the automation and intelligence of traditional plaster production, and to realize the transformation of Chinese Pharmacopoeia plaster quality inspection standards from qualitative to quantitative.
3.4.4 Automatic online control capsule filling machine
The focus of the research on fully automatic online control capsule filling machine is to break through key control technologies such as on-line closed-loop automatic detection of capsule filling and automatic adjustment of filling volume, and develop a fully automatic online control capsule filling machine [13] to eliminate human detection errors and reduce waste of raw materials , to ensure the controllable quality of capsule preparations in the production process, to realize the intelligent production of capsule preparations, and to trace all production data, so that my country's capsule filling machines can reach the international advanced level.
3.4.5 Intelligent Production Line of Traditional Chinese Medicine Pills
The research on the intelligent production line of traditional Chinese medicine pills focuses on breakthroughs in key technologies such as automation, digitalization and intelligence of traditional Chinese medicine pill equipment, and the development of digital and flexible production lines of traditional Chinese medicine pill equipment to realize the intelligent and digital production of traditional Chinese medicine pill equipment [14].
3.4.6 Production equipment for other traditional Chinese medicine forms
According to the characteristics of Chinese patent medicine preparations, and on the basis of referring to the research results of chemical medicine pharmaceutical equipment, innovatively design and develop various dosage forms of Chinese medicine pharmaceutical equipment suitable for the characteristics of traditional Chinese medicine, such as oral liquid, syrup, plaster, etc., breaking through various The key technology in the R&D, design and manufacturing process of preparation equipment lays the foundation for the production of high-quality Chinese patent medicine products.
3.4.7 Packaging equipment for traditional Chinese medicine preparations
The research on packaging equipment for traditional Chinese medicine preparations refers to the key breakthroughs in the computer three-dimensional dynamic simulation widely used in developed countries, the optimized design technology of the modular mechanical structure design concept and manufacturing technology of the whole machine, and the lightweight design technology of the product structure, and the development of high-speed, high-efficiency, Front-line (clean area) pharmaceutical packaging machinery and back-end packaging machinery (such as cartoning machines, intelligent testing equipment, wrapping machines, case packing machines) with high reliability operation, independent intellectual property rights, and meeting the individual needs of different pharmaceutical company customers , labeling machine, coding machine, palletizing machine, etc.) and intelligent three-dimensional warehouse and its highly integrated and intelligent high-tech, high-quality, high-speed, fully automatic packaging linkage production line. From "stand-alone equipment" to "automatic packaging production line", it has achieved full coverage of automatic packaging production for all varieties of drugs.
3.5 Development of key components of traditional Chinese medicine pharmaceutical equipment
In view of the current situation of backward technical performance, low manufacturing level, and low technological content of core components of domestic traditional Chinese medicine pharmaceutical equipment, promote the intelligent manufacturing of a batch of core components of traditional Chinese medicine pharmaceutical equipment.
3.5.1 Extraction and separation equipment for volatile oil of traditional Chinese medicine
Aiming at common problems such as low oil recovery rate and poor anti-interference ability of the oil recovery system during the extraction and separation of volatile oils in traditional Chinese medicines, the extraction and separation technology of volatile oils in traditional Chinese medicines and key components have been developed to achieve precise control of the condensation temperature of volatile oils and real-time liquid level detection of oil receivers. Accurately monitor the liquid level of the drug-oil-water mixture in the oil collector, and keep the liquid level in a stable range to achieve stable oil collection and improve oil collection efficiency[15].
3.5.2 Intelligent Manufacturing of Coating and Atomization Equipment
In view of the key problems affecting the atomization quality of the coating atomization, such as high atomization pressure, high consumption of coating materials, clogging of the spray gun, and unstable coating quality, in the atomization spray gun used for film coating, low-pressure coating atomization for film coating was carried out Systematic research [16]. Create an intelligent manufacturing system for low-pressure atomizing spray guns, solve technical problems such as uneven atomization, easy clogging, high consumption of coating materials, and difficult cleaning, and improve the stability of the film coating atomization system.
3.5.3 Transformation of hot air system of fluidized bed granulation drying equipment
Aiming at the key issues such as the large amount of heat required in the fluidized granulation and drying process, resulting in high power of the equipment heater, and the waste of most of the available heat, the energy-saving technology and the drying process of the hot air system of the fluidized bed granulation drying equipment were developed The tail gas recovery and utilization device [17] can improve the energy utilization rate of the fluidized bed granulation and drying equipment, thereby reducing the production cost.
3.5.4 R&D and manufacturing of intelligent components for Chinese patent medicine production equipment
In the field of intelligent key components of traditional Chinese medicine production equipment, the performance level and reliability of key components such as sensors and control system modules supporting the host are low, and the reliability is poor. Keep up with the international mainstream technology and form independent research and development and design capabilities [18]. Key breakthroughs in new sensors, high-strength cutting parts
Part forming technology, precision manufacturing technology of high-precision control components, key core technologies involved in high-reliability hydraulic, pneumatic and sealing components, and the establishment of intelligent, automated and digital equipment production lines for traditional Chinese medicine [19].
4 Conclusion and prospect
To a certain extent, the development status and level of traditional Chinese medicine pharmaceutical equipment
Affecting the development of the entire Chinese medicine industry, it is an important link related to the development of the Chinese medicine industry, and it is also an important symbol that determines the manufacturing level of Chinese medicine pharmaceutical equipment in my country. As the upstream industry of the pharmaceutical industry, Chinese medicine pharmaceutical equipment enterprises are affected by the demand of downstream Chinese medicine pharmaceutical enterprises and the upstream materials, automation technology, mechanical power technology, etc., which have a good driving effect on the development of upstream and downstream industries [20]. With the in-depth implementation of "Made in China 2025", combined with the implementation and improvement of the new version of GMP, the demand for new high-efficiency, energy-saving and intelligent traditional Chinese medicine pharmaceutical equipment will continue to expand.
The pharmaceutical equipment industry will usher in new opportunities for development.
