Research Progress Of Cistanche On Anti-aging

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Keywords: Cistanche/pharmacology aging/drug effect review literature

Cistanche deserticola Y. C. Ma is the fleshy stem with scale leaves of the Orobanchaccae plant Cistanche" also known as Dayun, Longitudinal Rong, Rongrong, Goblin, Golden Bamboo Shoot. *It is listed as a genuine product in the Chinese Pharmacopoeia. There are also medicinal varieties: Cistanche salsa lC. A . Meg I G.Beekl and Minsheng Cistanche [C-ambigua (Bge. J G.Beek] and Cistanche EC. tubulosa (Schenk) R. uight]. It has the functions of nourishing the kidney and strengthening yang, filling the essence and marrow, nourishing blood, and moisturizing dryness. "Indications of men’s impotence, female infertility, vaginal discharge, blood collapse, cold waist and knee pain, blood dryness, constipation, etc." Removal of cold and heat pain in the stem • Nourish the five internal organs, strengthen the yin, and nourish the vital energy. Women's disease seven "Medicinal Properties" called "benefit the marrow, delight the color, and prolong the life". £Rihuazi Materia Medica says it "can absolutely cure men." Yang is not prosperous • Females will not produce yin, nourish the five internal organs, grow muscles, warm the waist, men and sons ejaculate, and can be seen that the physicians of the past dynasties regarded Cistanche Yip as a good medicine for invigorating the kidney and prolonging life. In recent years, with the development of modern science and technology: its effect of delaying aging and prolonging years has been confirmed by the scientific research institute. The author made a review on the research on the anti-aging of Cistanche deserticola."

Cistanche has an anti-aging effect

Click to organic Ciastanche products for anti-aging

1 Research on the role of anti-aging

1.1 The effect of L, I on the lifespan of fruit flies: Cistanche has a significant impact on the lifespan of fruit flies. Add the Cistanche of Icin, 5 blessings, 1 biomedical quantity) to the basic medium, and the control group is the basic medium = As a result, the longest lifespan of fruit flies in the three treatment groups. Male 3D days, 74 days, 75 days: females 31 days, 73 days, flower days; higher than the control group males 66 days, females 65 days, half of the lethal day's males 6GM 5 days, 6L. . Days, 62.0. Days. Female 60.

50 days, 6L 45 days, 62.25 days. Also higher than the control male 58.75 Days, female 58. E days, the average life expectancy is prolonged, there is a significant difference of 0. U5, P<O. 0L.P<0. 01>.1.2 The impact on the viability of mice; male Kunming mice weighing 20~4 were randomly divided into 4 groups, and the 3 drug groups were given 3 kinds of decoction of meat and water, Ct. 02ml/g<each nil is equivalent to crude drug Igl for 14 consecutive days.1 Pharmacy Bureau of the Eighth First Hospital of the Chinese People's Liberation Army, Nanjing City, Jiangsu Province <210002) 3 The Fourth Military Medical University of the Chinese People's Liberation Army 3 The First Military Medical University of the Chinese People's Liberation Army Received Date, 1995-06-25

1.2 The weight of the mice in the medication group increased significantly. Compared with the blank control group, Cistanche, salt raw meat from cistanche, and Cistanche tubulosa all had significant differences cp<o-01-P<0. 01, PV 0. 05 J, normal pressure Hypoxia tolerance is also significantly better than the control group PVO, 01. p<0.01.P<0, 05, fish weight swimming time is significantly prolonged lP<0.01.P<0.05, Pv-(J. 05 ) 0 to cortisone-induced-yang deficiency mice taking Cistanche also has a significant weight gain effect<P<0-01); the freezing resistance time is significantly prolonged Pvt. 01); and it can improve the mice's "yang deficiency" Signs caused strong free radical damage to the mice in the aging model group caused by d galactose and the three administration groups. The control group did not enter the Kd environment. As a result, the mice in the administration group took longer to swim than the model. Group<P<0. 05, P<0. 01;. Freezing time was significantly higher than the model group (PVQ.01), and the normal pressure hypoxia-tolerant survival time was significantly improved in the normal pressure group, which was significantly different from the control group ( P<0. 05. P<0. O1) S: D experiments have proved that Cistanche not only has the effect of prolonging the lifespan of normal mice but also can significantly extend the "Yang deficiency" and free radical damage mice in harsh environments Survivability.

1.3 The effect of L3 on sexual function and monoamine transmitters: The decline of sexual function is an important sign of body aging. The phenylpropanoid two compounds in Cistanche, ergoline, roujingrongcheng A, and C have an antagonistic effect on the learning and sexual dysfunction of male mice caused by suspension stress. All sea urchins have antagonistic dysfunction Function = Cistanche can enhance the luteinizing function of the hypothalamus-pituitary gland-ovary. Improve the response of the pituitary gland to the luteinizing hormone-releasing hormone and the response of the ovaries to the luteinizing hormone as follows: the function of the thalamus-pituitary-gonadal axis and the monoamine neurotransmitter in the brain It is closely related to the quality. The sirens powder (Gusheng medicine/day) can increase the norepinephrine (INA) in rats with "Yang deficiency" caused by cortisone (lP<0.001) and decrease the adrenaline. rAJ has a recovery effect (P<0.a5K "Yang Deficiency" and normal rats dopamine<DA) are both elevated (P<0.05, P<0.01 pi. 3,4- 2 hydroxyphenyl acetic acid (DOPAC) Decrease <PV 0. Si), and make normal rats 5-S tryptamine G —HT) increase lP<0. 00LK after medication, "Guangyang Deficiency" and normal large tests showed DA/IXJPAC and 5-HT/ 5-Hydroxy Hem Acetic Acid (f5-HIAA) ratio increased (P<0- 01-0. 001) r,z\ Rhizoma Root Ethanol Extract (100,200mg/kg, 2 times/■day, can increase the hypothalamus NA content, the increase of NA in the high-dose group showed a statistically significant difference fP<0.01 >, which significantly increased the ratio of DA/DOPAC<P<0.05), which increased the levels of DA, DOPAC, and NA in the striatum It shows a rising trend. It can be seen that Cistanche and its alcohol extract can enhance the function of the pituitary gland and gonadal by affecting the monoamine neurotransmitter in the brain, thereby delaying the decline.

1.4 The impact on immune function; with the increase of age, the immune function declines, and disorders occur in the elderly, especially the function of small cells is significantly reduced. It is found that the low concentration of the decoction of meat shuangrong water can significantly improve the Ea rosette rate of human peripheral blood lymphocytes (P< "Shu Ba but has no effect on the Et rosette rate" Influence, high concentration (SOmg/'m]) inhibits Ea and Et rosette rate 0. Oil: High or low concentration of meat from puree reduces the percentage of ANAE lymphocytes 5-= lOCmg/kg water extract to mice Gavage. Both spleen drug dosage groups significantly increased the weight of the spleen and thymus (i'P<0. NL, P<n. birth), which caused delayed hypersensitivity in mice sensitized by sheep red blood cells <SRBC I (DTH) enhanced (PCO. 01 significantly increased the number of lymphocytes in the peripheral blood of mice' H-TdR parameter iP<u. C1) and the effect was enhanced with the increase of the amount of the agent; significantly increased plaque-forming cells<PFC value<P =0.ul>, and the hemolysin value is higher than the control maggot tPv n. Q5. P<0. It can also significantly increase the phagocytic percentage of peritoneal macrophages "Vu. history> and the phagocytic index <PO. 01>, making macrophages Intracellular cAMP content increased (P<0.01>, cGMP content decreased (P<0.01), rAMPAzGMP ratio increased significantly, P<O.un, which may be one of the mechanisms that enhance the phagocytic function of macrophages ",

Cistanche has anti-aging effect

2 Research on the mechanism of anti-decay years

2.1 Effects on Free radical damage and related enzymes: Recent studies have shown that • aging is closely related to the lipid peroxidation of free radicals in biological membranes • leading to membrane structure damage and functional inactivation = under normal circumstances, superoxidation Substances are mainly cleared by SOD. As the age increases, the SDD activity of the aging body is weak, the antioxidants decrease, and the free radical damage factor <OFR-MRA> increases to cause the body to grieve. “To observe the relationship between aging and free radicals and related enzymes” will Both the d-galactose-induced premature aging model group and the administration group caused free radical damage (. .9-lO ^Oj concentration). As a result, the activity of monoamine oxidase in the brain tissue of mice in the two doses of 320,40g/kg increased inhibited<P<0. U5.PVO.O1J, serum SOD activity in the drug group was significantly increased, P<0. D5, P<0.01J, plasma, brain, liver tissue lipid peroxides (LPO) Significantly decrease <P<0-01>: 3:, 2. 5, 12- 5, 31. 25g/kg (crude drug amount) Cistanche aqueous solution can significantly increase the SOD activity of mouse red blood cells (PV0. O5, PVO "D5.PvO,) l), significantly reduce the lipid content of myocardium: The SOD activity and hemoglobin<Hb\ content of mice caused by Qi-Nengzhisong-Yang Deficiency are reduced; *Grey Rong Decoction 8g/kg. , Tian 112 Qi Decoction) continuously irrigating mice eyes for 3D days, the red blood cell membrane Na+-K+-ATPase activity was significantly increased (P<0.01.n =®. This may be one of the mechanisms of the tonic effect.

2.2 The effect on protein and nucleic acid content, Cistanche has a small effect on the decrease and increase of liver nucleic acid content of "Yang deficiency" and "Yin deficiency" animals. It can significantly improve the hydroxyl caused by -' Yang deficiency" The synthesis rate of ON A in mouse liver and spleen promotes RNA synthesis. Improves the acid metabolism of protein. It increases the weight of mice, but there is no significant difference from the normal group. The mechanism may be that Cistanche contains a kind of activating acid reduction. The biological activity of the enzyme: 3gJkg of meat decoction from Congrong (Decoction J can antagonize the protein decomposition caused by weight-bearing exercise, and the serum urea nitrogen (BUN, content) is significantly reduced (P<0.05) After weight-bearing exercise, mice in the control quiet group had obvious nucleoprotein body-degranulation phenomenon in the liver endoplasmic reticulum, while in the experimental exercise group there was no degranulation phenomenon. Aging is a normal physiological process of the human body. But its aging physiology The changes involve the whole body multifunctional system•Causes metabolic disorders of the body, causes the dysfunction of the body’s various systems, and further aggravates the aging process. Cistanche has a two-way regulation effect on the immune system function with low concentration enhancement and high concentration inhibition, which is beneficial to "Yang Deficiency" rats Hypothalamus NA has an enhanced effect, and at the same time, the decreased A has a recovery effect, so that the concentration of A and A can be restored to a normal level, correcting the body's dysfunction, and has the characteristics of strengthening the body. Cistanche has also reduced the DNA synthesis rate of mice with "Yang Deficiency" It can improve the DNA synthesis rate of normal animals, but it can not increase the normal animal DNA synthesis rate. It proves that Roujingrong has the effect of regulating the metabolism of the body and has the characteristics of replenishing but not severe. Cistanche can also be achieved by affecting the content of monoamine neurotransmitters in the brain. Enhance sexual function, improve survival in harsh environments, significantly eliminate the increase in free radicals in aging animals, and strengthen internal protective factors). In short, Cistanche can antagonize the damage caused by aging factors to the body in a variety of ways. To achieve the effect of anti-aging years.

In recent years, the research on the active ingredients of Cistanche has developed rapidly. Now, it has been proved that Cistanche abstinence A and C, and the compound Maishufen can enhance learning and sexual function, and sea urchin has an antagonistic effect on low sexual behavior. E':. Polysaccharides have anti-aging effects." It can be seen that the anti-aging effect of meat paste is closely related to its various active ingredients. Further research on its active ingredients is necessary for the development and promotion of meat paste as a health care product.

Cistanche has an anti-aging effect

References

1. Han Lichun, et al., Experimental study on the anti-aging effect of Cistanche, Shanghai Traditional Chinese Medicine Xin Zhi 19911: (llii 22.

2. Zhang Zhuan, etc.-Comparison of two kinds of Cistanche on nourishing kidney and importing yang. Chinese Journal of Traditional Chinese Medicine iqqjigEj, 169.

3. Sun Yun, et al. Xinjiang Cistanche Anti-free radical damage research. Chinese Journal of Traditional Chinese Medicine 19*1 W 433,

4. Zhu Yan. Xiang. Clinical application of lipid-lowering drugs. Journal of Traditional Chinese and Western Medicine 1 week 9: <3J I 1«3 F Li Baiqing, et al. Study on the cellular immune function of Chinese medicine for invigorating the kidney I. The effect of Xianling spleen and Neidongrong on the formation of E rosette and acid esterase activity of human Lymba cells, Journal of Bengbu Medical College 19 Pei.33), 1. b Zhang Hongquan, etc. The effect of Cistanche on the immune function of mice. Chinese and Western Medicine Journal: Snake Seven 736.