The Monomeric Compounds Of Quercetin And Piloside Are The Quality Indicators And Efficacy Soul Of Cistanche Deserticola
May 07, 2024
Cistanche deserticola is a perennial herbaceous parasitic plant with dry, scaly leaves and fleshy stems. It has been regarded as a powerful and nourishing precious traditional Chinese medicine since ancient times, and is known as "desert ginseng".
Desert living cistanche
Modern pharmacological research has shown that in addition to being a traditional Chinese medicine for tonifying the kidney and strengthening yang, the phenylethanolamine glycosides in Cistanche deserticola mainly include echinoside and piloside, which have a wide range of pharmacological effects, including antioxidant, neuroprotective, improving learning and memory, anti-inflammatory, anti-tumor, liver protection, and immune regulation.
Main Chemical Constituents of Cistanche deserticola
The antioxidant effect is mainly related to its phenolic hydroxyl structure; The neuroprotective effect is mainly achieved by effectively reducing the generation of free radicals, inhibiting the occurrence of oxidative stress reactions, and producing significant antioxidant activity, thereby having a good preventive effect on neuronal damage and apoptosis; The anti-tumor effect is related to its antioxidant activity; The protective effect on the liver is manifested by reducing the levels of ALT (alanine aminotransferase) and AST (aspartate aminotransferase) in serum and the content of MDA (malondialdehyde) in tissues, increasing the activity of SOD (superoxide dismutase), and inhibiting the activity of caspase-3 and TNF- α The level of tumor necrosis factor (TNF) effectively reduces free radical generation and anti-lipid peroxidation. Tu Pengfei et al. systematically studied the phenylethanolamine glycosides in Cistanche deserticola, among which the highest content of echinoside and piloside can reach 30%, which are the main functional soul.
effects of cistance-antitumor
Wang Linan et al. established a quality control method for phenylethanolamine in Cistanche deserticola using macroporous resin UV spectrophotometry, using echinoside as the reference substance. Li Chenghua et al. determined the content of phenylethanol glycosides in Cistanche deserticola by RP-HPLC, using echinoside, glycoside A, and glycoside A as control substances. Zhang Xuan et al. established an HPLC method for simultaneously determining the content of piloside and quercetin in Cistanche deserticola from different regions and hosts. Zhang Siju et al. used RP-HPLC to simultaneously determine the phenylethanolamine glycosides, including quercetin and anthocyanins, in Cistanche deserticola for quality standard research. Tu Pengfei et al. used reverse-phase high-performance liquid chromatography to qualitatively and quantitatively analyze the phenylethanolamine glycoside components such as quercetin and poolside in the raw materials of Cistanche deserticola and 25 commercial medicinal materials.
Main Chemical Constituents of Cistanche deserticola
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The Cistanche deserticola, which was included in the 2015 edition of the Chinese Pharmacopoeia, is a dried fleshy stem with scaly leaves from two species of plants, Cistanche deserticola and Cistanche tubulosa. Under the content determination item, the HPLC method was used to limit the main active ingredients of Cistanche deserticola, including echinoside and glycoside from Fructus Cistanche. The total content of echinoside and glycoside from Fructus Cistanche tubulosa should not be less than 1.5%, and the limit should be higher than 0.3% of Cistanche deserticola. Whether from literature reports or relevant standards, both quercetin and anthocyanin are quality indicators of Cistanche deserticola.
Phenylethanol glycoside is the main active component of Cistanche deserticola
