Unexpected Causes Of Parkinson's Disease

Apr 28, 2022

Parkinson's disease is a common neurodegenerative disorder in middle-aged and elderly people, which belongs to chronic diseases. Parkinson's disease is a developmental disease. If the disease is not controlled in time, it will become more and more serious, which will have a great impact on life and physiology. The main symptoms of Parkinson's disease are uncontrollable shaking of hands and feet and body stiffness, muscle stiffness, dystonia, inability to move, and difficulty turning over. Over time, it can also cause some non-motor symptoms, such as loss of smell, depression, constipation, and more. For Parkinson's disease, early detection and timely response are the best choices.


It can be seen from this that the symptoms of Parkinson's disease are very numerous and complex, and because the cause of the onset of Parkinson's disease is unknown, there is no clear reason for the treatment of the disease. We must learn more about the prevention and treatment of Parkinson's disease, and improve prevention and awareness. So, who in life is prone to Parkinson's disease? Dr. Wang Shilong said; "People with 4 types of characteristics must be careful."

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1. Middle-aged and elderly people are more likely to suffer from Parkinson's disease

       Parkinson's disease is a geriatric disease, and as you age, the muscles in your body age. Specifically, Parkinson's disease is caused by abnormal blood circulation, decreased exercise, and insufficient secretion of endocrine hormones in the body, so it is common to see patients' hands shaking, stiff, and walking slowly. The prevalence of this disease is higher in the elderly.

2. Timid and depressed people are prone to Parkinson's disease

      Because Parkinson's disease directly affects the human nervous system, resulting in tremors in human limbs or stiffness in muscles, which not only seriously affects the normal life of patients, but also causes great pressure on their psychology. Therefore, patients with Parkinson's disease often close themselves, are reluctant to communicate with the outside world, or are overly worried about their disease. If early and active treatment and psychological counseling are carried out, the depression will be relieved or disappeared with the improvement of symptoms after treatment, which is also the cause of Parkinson's.

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3. Frequent exposure to pesticides and other chemicals is more likely to develop Parkinson's

      For example, pesticides are the most common. In the United States, farmers used pesticides in the 1960s, and the number of Parkinson's disease patients will increase. Studies have shown that people who drink well water are more likely to develop Parkinson's disease because well water is used to contain pesticides, but it is a problem of pesticides. For example, pesticides, especially those used in rural areas, can increase the incidence of Parkinson's disease. Other heavy metals such as manganese and lead in air pollution can increase the incidence of Parkinson's disease.

4. Living in a room that is too humid is more likely to suffer from Parkinson's

       Wet conditions can produce mold, and mold can emit a substance that is harmful to the brain, dopaphenol. People living in such an environment are more likely to suffer from Parkinson's disease. In multiple Parkinson's patients, the same molds were found in their dobutol, and if patients were exposed to these toxins for a long time, the Parkinson's disease would continue to worsen. For this, our room should be kept dry and airy.

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Echinacoside in Cistanche can improve the behavioral defects of MPTP-induced PD model mice, increase the striatal dopamine (DA) metabolite 3,4-dihydroxypheny lacetic acid (3,4-dihydroxypheny lacetic acid, DOPAC), and high Vanillic acid (homovanillic acid, HVA) content significantly inhibits the apoptosis of cerebellar granule neurons caused by the activation of caspase-3 and caspase-8; reduces the overexpression of biliverdin reductase B in the brain of Parkinson's patients, suggesting Echinacoside may reduce the increase of biliverdin reductase B caused by oxidative stress through its anti-oxidative stress effect, and protect dopaminergic neurons from oxidative stress damage. Its neuroprotective mechanism may be similar to that of bile Decreased levels of chlorophyll reductase B are related; to the reduction of dopaminergic neurons and dopamine transporters in the substantia nigra of the brain of patients with Parkinson's disease, and can enhance neurotrophic factor [neurotrophic factor, NTF. brain-derived neurotrophic factor, BDNF) and nerves The activity and protein expression level of glial cell line-derived neurotrophic factor (GDNF) derived from the glial cell line can reduce the ratio of mRNA and protein in apoptosis and Bax/Bcl-2. In addition, echinacoside can significantly increase the content of dopamine, DOPAC, and HVA in the extracellular fluid of the striatum of patients with Parkinson's disease

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For more information:ali.ma@wecistanche.com

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