What Are The Stages Of Parkinson's Disease?

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Parkinson's disease itself is not a fatal disease, so it generally does not affect the lifespan of patients. And with the continuous innovation and improvement of treatment methods and levels, more and more patients can maintain a high level of motor function and quality of life throughout their lives. However, if there is no timely and reasonable treatment, it is easy to lead to the decline of body function, even the inability to take care of yourself, paralysis, choking, and other problems, and finally various complications, such as pneumonia, urinary tract infection, and other dangerous complications. disease and endanger the life of the patient.

Associate Professor Chen Wei from the First Affiliated Hospital of Jiaotong University introduced that he often finds when he sees a doctor that many Parkinson's disease patients do not understand the stage of their disease, and they are relatively blind in seeing a doctor and taking medicines. Serious? These problems". In response to the patients' questions, the course of Parkinson's disease is subdivided and sorted into the following phases, so that Parkinson's patients can make a reference.

Stage I: unilateral disease only,

Unilateral shaking of hands, feet, or stiffness, walking is not as smooth as usual, and things are unsteady. Because the impact on life is not great, it is often easily overlooked by patients and their families. If treated in time during this period, there is great hope for the patient's symptoms to be completely controlled!

Stage II: mild bilateral disease

The disease progressed from unilateral to bilateral, with shaking of the hands and even the whole body, increased stiffness, difficulty in daily activities such as buttoning buttons and holding chopsticks, difficulty walking, and poor balance.

Stage III: Bilateral disease with early balance disturbance

It is difficult to lift the leg, and the legs are like heavy sandbags tied to the legs. Walking in small steps, dragging and leaning forward, it is easy to fall. Unable to hold the bowl while eating, and need help from family members for daily activities such as turning over at night and taking a bath.

Stage IV: Severe disease requiring extensive help

Often involuntary drooling, difficulty swallowing, and slow eating. The speech is slurred, and the voice is very low, and it can only be heard clearly by others approaching. The expression is rigid, the mask face appears, the facial muscles are becoming more and more rigid, the face is expressionless, the eyes are rarely blinked, and the eye movements are also reduced. Exercise is difficult, and daily life is inseparable from the care of family members.

Stage Ⅴ: Complete inability to take care of yourself in daily life

Confined to a bed or wheelchair, life is completely incapable of taking care of yourself. Confined to a bed or wheelchair unless a family member helps. Some patients are only bedridden for a long time, unable to stand by themselves after sitting down, unable to turn over by themselves after being bedridden, and completely unable to take care of themselves in daily life.

It should be noted that active treatment is necessary from the beginning of the disease, especially for patients with stage 1-2, the course of the disease is relatively slow, and from the development of the disease, medication can maintain a basic living state, and active treatment is required during this period. , Correct and regular medication, if not actively treated, the condition will aggravate sharply.

After stage II, if the drug effect time is shortened and the control effect is poor, deep brain stimulation surgery can be used for treatment at this time, and the quality of life of the patients after surgery is higher.

Herbal medicines have attracted considerable attention in recent years, which are used to treat Parkinson's disease (PD) in China based on traditional Chinese medicine or modern pharmaco- logical theories. We summarized and analyzed the anti-Parkinsonian activities of herbal medicines and herbal formulations investigated in Parkinson's disease models and provide future references for basic and clinical investigations. All the herbal medicines and herbal formulations were tested on PD models in vitro and in vivo. The relevant compounds and herbal extracts with anti-Parkinsonian activities were included and analyzed according to their genera or pharmacological activities. A total of 38 herbal medicines and 11 herbal formulations were analyzed. The relevant compounds, herbal extracts, and formulations were reported to be effective on Parkinson's disease models by modulating multiple key events or signaling pathways implicated in the pathogenesis of PD. The plant species of these herbal medicines belong to 24 genera and 18 families, such as Acanthopanax, Alpinia and Astragalus, etc. These herbal medicines can be an alternative and valuable source for anti-Parkinsonian drug discovery. The plant species in these genera and families may be the most promising candidates for further investigation and deserve further consideration in clinical trials. Active components in some of the herbal extracts and the compatibility law of herbal formulations remain to be further investigated.