What Is Your Choice For Anti-fatigue?

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LI Jian-Kang et al

Keywords: Fatigue syndrome, anti-fatigue, fatigue, Lingzhi, Cistanche

Abstract

By studying the clinical manifestation, pathogenesis, damage, etc. of the body's fatigue, and being relative to the animal test of Lingzhi and Cistanche, proves that Lingzhi and Cistanche resist not only the Lack of oxygen but also fatigue.

Summary

Through the investigation of the clinical, pathogenesis, and hazards of human body fatigue, combined with animal experiments of Lingzhi and Cistanche it is confirmed that Lingzhi and meat ash do not only have hypoxia resistance but also have anti-fatigue effects.

Cistanche has the function for Anti-fatigue.

Introduction

Chinese herbal tonics have a certain effect on improving exercise capacity and eliminating fatigue, which has been confirmed by a large number of studies. It has the characteristics of yin and yang double tonic, qi, and blood balance, symptomatic treatment of symptoms and root causes, and has certain significance for athletes to strengthen their bodies and prevent fatigue syndrome.

In this topic, experiments on mice with Lingzhi, Cistanche, and other drugs have further confirmed the effects of Chinese herbal medicine on delaying fatigue, improving and enhancing sports performance, and enhancing body endurance.

Clinical manifestations of fatigue syndrome

Athletes have long-term physical and mental stress, fatigue, and chronic wasting diseases during heavy exercise training cycles, or people in busy social work, which cause the body's multiple systems and multiple organs to decline and continue to appear. The symptoms of sexual fatigue and weakness are called "fatigue syndrome". Its clinical manifestations are persistent fatigue, listlessness, dizziness, palpitations, shortness of breath, difficulty concentrating, memory loss, decreased thinking ability, upset, emotional instability, insomnia, hot flashes, night sweats, limb pain, Loss of appetite, etc. The performance of the middle and late-stage: each group of organs is in the fatigue decompensation period, and the corresponding organic disease is secondary.

Fatigue syndrome pathogenesis

The human body is in a state of high tension for a long time, the activity of brain nerve cells is tense, oxygen consumption increases sharply, causing neuro-humoral regulation and endocrine dysfunction, prone to cerebral hypoxia and decreased excitability; secondly, overwork, increased energy consumption, internal The environment is out of balance, the enzyme activity and ion metabolism in the body are disordered, which affects the cellularization process, the accumulation of lactic acid, soreness, and fatigue; thirdly, people suffering from chronic wasting diseases, such as anemia, blood loss, malnutrition, etc., such as working in an overworked environment or Excessive training accelerates the dysfunction of the central nervous system of the brain and leads to abnormal immune function. These people are overworked for a long time, which is the main pathological factor that causes the occurrence and development of fatigue syndrome.

Cistanche can enhance the Anti-fatigue function, to release fatigue syndrome.

Fatigue syndrome prone group and harm

Fatigue syndrome mostly occurs in athletes and mental workers. Its harm is not only manifested in fatigue, weakness, mental confusion, and other symptoms but even forced to stop training and work. If it is not treated in time, further development will be caused by the nervous system. , Endocrine system dysfunction, low or weak immune function, leading to high blood pressure, hyperlipidemia, cerebral arteriosclerosis, myocarditis, coronary heart disease, nephropathy, neurasthenia, severe cases can develop into brain inflammation, and even life-threatening. Therefore, it is necessary to be fully aware of this disease and should be treated promptly once the disease is ill, so as not to miss the opportunity for treatment.

Lingzhi and Roudongrong anti-fatigue drug experiment

At present, the research on anti-fatigue drugs in my country is relatively extensive, such as "Comprehensive Observation of the Effects of Chinese Medicine Kidney-tonifying Drugs and Tonic Drugs on Athletes' Function State and Exercise Ability" by Wan Jin and others from the Institute of Sports Medicine of the National Sports Commission, and the sports medicine of Xi'an Institute of Physical Education, etc., the research confirms Some traditional Chinese medicine materials can improve the body's aerobic and anaerobic endurance, and promote the elimination of exercise fatigue.

In order to further explore the anti-fatigue and anti-anoxia effects and potentials of traditional Chinese medicines, this experiment selected Lingzhi as the anti-fatigue drug for Ding experiment, combined with contemporary Chinese medicine anti-fatigue and anti-anoxia pharmacological research, also achieved obvious results.

Materials and methods Lingzhi produced by the Edible Fungus Service Center of the Department of Food Science of Shanxi University and Cistanche provided by the Provincial Pharmaceutical Company are used as raw materials. The mice were provided by the Animal Room of the Provincial C Medical Research Institute.

Hypoxia tolerance test Twenty two-month-old white mice weighing 42.15±1.28 g, half male and female. There are 5 animals in each group, each group of male and female is the control group. The control group eats ordinary feed; the Lingzhi group eats ordinary feed plus Lingzhi. The feeding period is 30 days. Inside the bottle. Record the survival time (minutes) of the mice in the bottle, see Table 1.

Anti-fatigue experiment Thirty-two-month-old small rats weighing 41.24±1.90g were randomly divided into 6 groups, 5 in each group, half male and half female, and a control group; Lingzhi group; Cistanche group. The formula and breeding method are the same as above. After 30 days of breeding, the mice are placed in the same container for swimming, the water depth is 35cm, and the water temperature is 25±1℃.

Analysis of results

The results showed that in the hypoxia tolerance experiment, there was a significant difference between the administration group and the control group (p<0.01), especially the longest survival time of male mice in the administration group. Hypoxia. Some data show that ginseng, Schisandra, and other medicines can not only resist hypoxia but also reduce oxygen consumption. The chemical composition of Lingzhi is more complicated, and further research is still underway.

In the anti-fatigue experiment, the swimming time of mice consuming Lingzhi was significantly longer than that of Cistanche and the control group (P<0.01), proving that Lingzhi has anti-fatigue effects. According to literature reports, the body’s exercise capacity is closely related to the amount of ATP contained in its muscles, the consumption of glycogen, and the accumulation of lactic acid metabolites. Can Lingzhi increase the content of ATP in muscles and reduce blood lactic acid production and glycogen consumption. The anti-fatigue ability, its mechanism remains to be explored.

Conclusion

Research on fatigue tends to be more unified. Fatigue syndrome is a multi-system, multi-organ functional decline and damage. The explanation of fatigue in Chinese medicine. It is believed that the main reason is that the balance of the body's meridians, collaterals, viscera, qi, and blood, and yin and yang are unbalanced due to strong labor, especially the multi-factorial result of fatigue, and even weakness. In the past ten years, with the application of high technology, new progress has been made in fatigue research. At present, the concept of fatigue is becoming more unified, and the understanding of its mechanism has evolved from the simple energy consumption or accumulation of metabolites to the understanding of the comprehensive effect of multiple factors. The level of research has been changed from the structure of cells and sub-cells. The function goes deep into the biomolecular or quantum level. In 1982, FMuiards proposed the "mutation theory" of fatigue. Starting from a three-dimensional perspective, it connected the occurrence of fatigue with energy consumption, decreased muscle contractility, and loss of cell excitability or activity, and considered the usual fatigue pathway. It occurs in the process of energy consumption and cell excitability or activity attenuation caused by exercise, and a sudden decline in ability occurs to avoid further depletion of energy reserves. In 1989, Machlam believed that the catastrophe theory emphasized the relationship between "energy" and "electrical conduction", explaining the reason for the sudden drop in muscle strength. In 1990, when Huhmon observed the intermittent contraction of the quadriceps muscle, it was found that the ATP·CP content decreased and the lactate increased at the same time. The intramuscular contractile force slowly weakened in the first 20 seconds, and suddenly decreased after 20 seconds, providing a direct experimental basis for the catastrophe theory.

Reference

This source is by LI Jian-Kang et al.