A New Choice For Patients With Kidney Disease! Stem Cell Therapy Repairs Kidney Damage!

Statistics show that 850 million people worldwide suffer from kidney disease. Chronic kidney disease affects more than 10% of the global population, and the incidence is rising, causing 5 to 10 million deaths each year. The prevalence of kidney disease in my country has reached 10.8%, and chronic kidney disease is becoming a major killer of human health. The current treatment methods cannot repair the damaged kidney tissue and restore the original kidney function, which is an important reason for the high mortality rate of chronic kidney disease. However, kidney transplantation has risks, and there is a risk of rejection after surgery. Long-term use of anti-rejection drugs is also required. The resistance is poor, and the risk of infection is relatively high.

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Chronic Kidney Disease Facts and Figures

Chronic kidney disease (CKD) is an irreversible disease of renal structure and function caused by a variety of reasons. There are no symptoms in the early stage, only mild abnormalities in biochemical tests and urine tests, and it can develop if it continues to progress. It is uremia, which causes diseases of the heart, breathing, bones, blood, metabolism, and other systems of the whole body.

Research data shows that the global prevalence of chronic kidney disease is about 14.3%, and the prevalence of CKD in China is about 10.8%. Millions of people die each year due to a lack of access to treatment. Worldwide, approximately 1 in 5 men and 1 in 4 women have CKD in people aged 65 to 74. CKD has a high prevalence rate, poor prognosis, and expensive medical expenses. With the aging of the population and the prevalence of obesity, hypertension, diabetes, and other diseases, the incidence of kidney disease is increasing rapidly, and it has become an important public health problem that seriously affects the health of the Chinese people. Hygiene issue.

At present, kidney transplantation is the only definitive treatment method to restore kidney function, but there are challenges such as rejection and lifelong immunosuppression. In addition, the "short supply" of transplanted organs is also a major problem in treatment. While studies have found that stem cells can improve kidney function, in preclinical models, positive data have been obtained, making them potential materials for regenerative medicine.

Principle of stem cell therapy for nephropathy

Stem cells can proliferate indefinitely, differentiate in multiple directions, and have the characteristics of hematopoietic support, immune regulation, and self-replication. They can be used as ideal "seed" cells for the repair of tissue and organ damage caused by lesions. In recent years, studies have found that stem cells can differentiate into renal innate cells, renal parenchymal cells, etc., so they have a good repair and reconstruction effect on renal function, and have the following six advantages:

①It has strong proliferation ability and multi-directional differentiation potential, which can proliferate and differentiate and produce a large number of offspring.

②It has the function of immune reconstitution, inhibiting the proliferation of T cells and their immune responses through the interaction between cells and the production of cytokines.

③ The source is convenient, easy to separate, culture, expand and purify, and it still has the characteristics of stem cells after multiple passages and expansions.

④ Low immunogenicity, so there is no characteristic of immune rejection, and there is no problem with blood type matching.

⑤ Long-term passage does not change the biological characteristics and can differentiate into renal innate cells, muscle cells, hepatocytes, osteoblasts, chondrocytes, and other cells.

⑥It has homing, and damage signals can stimulate the migration and differentiation of stem cells to damaged organs and tissues, and repair damaged cells.

Clinical study of mesenchymal stem cells in the treatment of kidney diseases

Mesenchymal stem cells are cells capable of self-proliferation and can be further differentiated into various functional cells after induction. Due to the advantages of strong plasticity, easy access, easy operation, and almost no immune rejection, mesenchymal stem cell therapy has created a new avenue for the treatment of almost many diseases. In recent years, mesenchymal stem cells have achieved promising results in clinical trials of various types of kidney diseases.

So far, there are more than 100 clinical trials of mesenchymal stem cells in the treatment of kidney disease included in the National Health Database (ClinicalTrials.gov).

The findings suggest that mesenchymal stem cells promote the recovery of kidney function in the treatment of various types of kidney diseases. A clinical study published in the journal J Am Soc Nephrol showed that atherosclerotic renovascular disease (RVD) is caused by reduced renal blood flow and glomerular filtration rate, which leads to kidney damage. Renal blood perfusion, oxygenation, and glomerular blood perfusion in patients with the atherosclerotic renovascular disease (RVD, a decrease in renal blood flow and glomerular filtration rate leading to kidney damage) three months after infusion of mesenchymal stem cells Filtration efficiency has been improved.

A study published in the journal Stem Cell Research & Therapy showed the safety and efficacy of mesenchymal stem cells in autosomal dominant polycystic kidney disease (ADPKD). The mean serum creatinine level of the patients increased gradually from 2±0.3 mg/dl to 2.5±0.4 mg/dl. Mean serum creatinine remained stable at 2.5±0.6 mg/dl after 12 months of mesenchymal stem cell therapy.

Another clinical trial involving 81 patients investigated the therapeutic role of mesenchymal stem cells in refractory lupus disease. The results showed that 60.5% (49/81) of the patients had significant remission of kidney damage 12 months after infusion of mesenchymal stem cells. Kidney disease is chronic damage to kidney tissue, which can lead to systemic diseases such as coronary heart disease, heart failure, and stroke. Traditional treatment methods are difficult to reverse the disease process.

In recent years, more and more research results have shown that mesenchymal stem cells play a role in the treatment of various kidney diseases, which also opens up a new way of thinking for the treatment of kidney diseases. In the future, with the further development of clinical research, stem cells are expected to become a new clinical choice for kidney diseases.

for more information:ali.ma@wecistanche.com