Can These Commonly Used Drugs For Kidney Disease Increase Serum Creatinine?

A patient with kidney disease shared in the community that his creatinine increased after taking palindromic drugs.

Click to Cistanche for kidney disease

As drugs commonly used in the treatment of chronic kidney disease, it is not uncommon for kidney patients to encounter such problems. Today I'm going to talk to you about Prilim and Sartan drugs.

RAS inhibitors

RAS inhibitors (renin-angiotensin inhibitors) include two classes of drugs:

One type is ACEI (angiotensin-converting enzyme inhibitor), representative drugs include captopril, enalapril, etc.; the other type is ARB (angiotensin receptor blocker), representative drugs include irbesartan, Valsartan, Telmisartan, etc.

Generally speaking, the time it takes for this type of drug to reduce proteinuria is about 6 weeks. Therefore, you should not rush for success when using this type of drug to reduce proteinuria or delay the progression of kidney disease.

Professor Li Detian, chief physician of the Department of Nephrology, Shengjing Hospital Affiliated with China Medical University, once shared that RAS inhibitors are drugs of universal significance in the treatment of chronic kidney disease.

However, Professor Li Detian also emphasized that whether it is a Sartan or an antihypertensive drug if used properly, it can delay the progression of kidney disease and reduce proteinuria; if used improperly, it will lead to an increase in creatinine and an increase in serum potassium. High, even life-threatening. In addition, about 17% of people will cough after taking promethazine drugs, so they cannot take the medicine without permission and need to communicate with their doctor.

Professor Li Detian talks about his experience

When treating patients with chronic kidney disease, the observation cycle is generally 3 months. Of course, acute cases need to be evaluated separately, and the observation cycle maybe 2 weeks or 1 month.

To delay the progression of chronic kidney disease, this type of drug can be used when creatinine is normal or slightly elevated (such as creatinine 200umol/L, 300umol/L). However, to prevent uncontrollable side effects, especially in patients with high creatinine and elderly patients, they must be used under the guidance and supervision of a doctor.

Can pilin and sartan drugs be used together?

Individual patients can use it together. Because some patients can completely prevent the high excitement of renin and angiotensin by using it together.

Delaying the progression of kidney disease has a long way to go

Chronic kidney disease is not a single disease. It is a disease in which chronic kidney damage is caused by multiple reasons and diseases, and the kidney function gradually deteriorates, eventually developing into uremia.

In 2023, a study published by Zhou Maigeng of the Chinese Center for Disease Control and Prevention, Hou Fanfan, an academician of Nanfang Hospital of Southern Medical University, and others in JAMA Internal Medicine showed that the prevalence of CKD, impaired renal function, and proteinuria in my country were respectively The rates are 8.2%, 2.2% and 6.7%, but the awareness rate is only 10%. Then, based on a population of 1.4 billion and a prevalence rate of 8.2%, there are approximately 115 million CKD patients in my country.

There is still a long way to go to delay the progression of chronic kidney disease. In addition to drug treatment, daily life management is also crucial to delaying the progression of kidney disease.

How Does Cistanche Treat Kidney Disease?

Cistanche is a traditional Chinese herbal medicine used for centuries to treat various health conditions, including kidney disease. It is derived from the dried stems of Cistanche deserticola, a plant native to the deserts of China and Mongolia. The main active components of cistanche are phenylethanoid glycosides, echinacoside, and acteoside, which have been found to have beneficial effects on kidney health.

Kidney disease, also known as renal disease, refers to a condition in which the kidneys are not functioning properly. This can result in a buildup of waste products and toxins in the body, leading to various symptoms and complications. Cistanche may help treat kidney disease ase through several mechanisms.

Firstly, cistanche has been found to have diuretic properties, meaning it can increase urine production and help eliminate waste products from the body. This can help relieve the burden on the kidneys and prevent the buildup of toxins. By promoting diuresis, cistanche may also help Reduce high blood pressure, a common complication of kidney disease.

Moreover, cistanche has been shown to have antioxidant effects. Oxidative stress, caused by an imbalance between the production of free radicals and the body's antioxidant defenses, plays a key role in the progression of kidney disease. ies help neutralize free radicals and reduce Oxidative stress, thereby protecting the kidneys from damage. The phenylethanoid glycosides found in cistanche have been particularly effective in scavenging free radicals and inhibiting lipid peroxidation.

Additionally, cistanche has been found to have anti-inflammatory effects. Inflammation is another key factor in the development and progression of kidney disease. Cistanche's anti-inflammatory properties help reduce the production of pro-inflammatory cytokines and inhibit the activation of inflammation mandatory pathways, thus alleviating inflammation in the kidneys.

Furthermore, cistanche has been shown to have immunomodulatory effects. In kidney disease, the immune system can be dysregulated, leading to excessive inflammation and tissue damage. Cistanche helps regulate the immune response by modulating the production and activity of immune cells, such as T cells and macrophages. This immune regulation helps reduce inflammation and prevent further damage to the kidneys.

Moreover, cistanche has been found to improve renal function by promoting the regeneration of renal tubes with cells. Renal tubular epithelial cells play a crucial role in the filtration and reabsorption of waste products and electrolytes. In kidney disease, these cells can be damaged, leading to damaged renal function. Cistanche's ability to promote the regeneration of these cells helps restore proper renal function and improve overall kidney health.

In addition to these direct effects on the kidneys, cistanche has been found to have beneficial effects on other organs and systems in the body. This holistic approach to health is particularly important in kidney disease, as the condition often affects multiple organs and systems. che has been shown to have protective effects on the liver, heart, and blood vessels, which are commonly affected by kidney disease. By promoting the health of these organs, cistanche helps improve overall kidney function and prevent further complications.

In conclusion, cistanche is a traditional Chinese herbal medicine used for centuries to treat kidney disease. Its active components have diuretic, antioxidant, anti-inflammatory, immunomodulatory, and regenerative effects, which help improve renal function and protect the kidneys from further damage. , cistanche has beneficial effects on other organs and systems, making it a holistic approach to treating kidney disease.