Cerebral Protective Effect Of Cistanche in Alzheimer's Patients
Mar 11, 2022
Contact: Audrey Hu Whatsapp/hp: 0086 13880143964 Email: audrey.hu@wecistanche.com
LI Nan BAI Hongying LOU Jiyu Department of Internal Medicine, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China
[Abstract ]Objective To investigate the cerebral protective effect of cistanche on mild Alzheimer's disease ( AD ) patients. Methods Mild AD patients were randomly divided into 3 groups. The changes of ADAS—cog were evaluated by MMSE and 1.5 TMRI. Results Drug treatment group of MMSE and ADAS cog score was significantly better than the control group after 48 weeks, treatment group in the hippocampal volume in the progressive atrophy of the change was not obvious, and drug treatment group in cerebrospinal fluid ( CSF ) t-tau, TNF alpha and IL—1 beta levels compared with the control group compared with decreased significantly. Conclusion After the agent's treatment of cistanche deserticola, the cognitive status of mild Al) patients has been significantly improved, cistanche can slow the hippocampus atrophy of the cerebral protective effects of mild AD patients with potential.
[Key words ]：Alzheimer's disease, Cistanche, Cognitive fiinction, T—tau, TNF— a , IL—1 P
Cistanche Anti-Alzheimer's disease
Alzheimer's disease (AD) is a series of clinical syndromes of neurodegeneration. It is manifested by a progressive decline in cognitive ability and personal life ability." AD patients•The increased tau protein in the cerebrospinal fluid has become a diagnosis: One of the important indicators of "Rucongrong is a fully parasitic desert plant. Its main chemical substance, phenylethanol glycosides, is considered to have an effect on the central nervous system." This study analyzes the potential neuroprotective effect of Roucongrong on AD
1 Materials and methods
The 24 participants were all from the Second Affiliated Hospital of Zhengzhou University. They had similar education levels, and the selection criteria were Mini-mental state examination (MMSE) early; Table 4 (21 ~ 26 points) and Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) is a table (7-17 points); the exclusion criteria are acute and chronic infections, tumors, the use of donepezil, memantine, ginkgo biloba preparations, the use of anti-infective drugs, steroid drugs, and C-reactive protein N10mg /L, All patients signed the informed consent form. This study was obtained by the Ethics Committee of the Second Affiliated Hospital of Zhengzhou University Author Unit: 4501114 Department of Neurology, The Second Affiliated Hospital of Zhengzhou University Participants were randomly divided into 3 groups: Cistanche treatment group (n=10): Oral cistanche capsules (Z20080047) 0.9 g/d for 48 weeks; Donepezil treatment group (n=8): 11 servings Donepezil tablets (Aricept, National Medicine Standard H20050978) 5 mg/d, taken for 48 weeks; control group (n=6): no drug treatment, each participant underwent MMSE and ADAs-cog amount: table evaluation data by One -way ANOVA test to test differences between groups using GE 1.5 TMRI scanner for MRI scanning, bilateral hippocampal volume and whole-brain volume using statistical parameter map (SPM99) 9 calculations, all data are analyzed by SPSS 13.0 data package and used for One-way ANOVA test For group comparison, Bonferroni was used for comparison between the two groups, and P <0.05 was considered statistically significant.
Oral cistanche capsules
2 Results
After 48 weeks of medication, the drug treatment group had an improvement in cognitive level compared with the control group (P <0.05), but at 24 weeks of medication, the difference in this index was not obvious. Difference (P>0.05); MMSE performance improved in the drug group (P <0.05); ADA-cog performance improved in the drug group (P <0.05); bilateral hippocampal volume in the control group experienced sustained atrophy within 48 weeks (P <0.05), while the volume of Haiwu in the drug treatment group did not change significantly (/>0.05).
Cistanche improve memory
3 Discussion
Studies have revealed that Roucong preparations can improve the cognitive ability of patients with mild AD, and slow down the atrophy of the patient's sea culm. It is believed that Cistanche preparations can inhibit the accumulation of t-tau by reducing the amount of TNF-a and IL-1(3). It is a classic part of traditional Chinese medicine theory. The human body is considered to be composed of two opposite parts: Yin and Yang. According to the theory of Yin and Yang, Qi belongs to Yang. Blood and body fluid belongs to Yin, which together constitutes the foundation of the human body. The concept of yin and yang to reveal the occurrence of disease and treat Alzheimer’s disease (AD) is considered to be insufficient yang. Meat puree is considered to be a medicine to invigorate the kidney and yang, and it may have an effect on AD. The first category of phenethyl alcohol is meat ash. An important active substance in Rong, in vitro experiments, confirmed that it can inhibit the production of IL-10 and TNF-a in peritoneal macrophages." Our research shows that after 48 weeks of treatment with Rong Cong, t-tau. TNF-a and IL -According the decrease in the expression, it indicates that the active ingredients of Cistanche can penetrate the blood-brain barrier and participate in the pathological process of AD. Our findings also show that t-tau, TNF-a and IL-1 are related. Rong can reduce the amount of TNF-a and IL-IP and then reduce the accumulation of tau protein. After the treatment of Rong Cong Rong, the level of t-tau in the cerebrospinal fluid of AD patients will be effectively eliminated with the decrease of TNF-a and IL-qiong, suggesting that Meat ash preparations may affect the aggregation of tau protein by inhibiting the expression of TNF-a and IL-10 in the cerebrospinal fluid. In any case, our experiment did not isolate and target a certain biological component of the cistanche. The research should focus on the analysis of its important components:
In summary, Cistanche preparation can improve the cognitive function of patients with mild AD and slow down hippocampal atrophy. Compared with donepezil, its therapeutic effect is not statistically different. Its price is low and maybe more suitable for China and some developing countries.
Cistanche prevents Alzheimer's disease
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