Cytological And Pharmacological Mechanism Of Antioxidant Effect Of Cistanche Deserticola

Jun 27, 2023

People use oxygen for respiration and metabolism, but when the human body is using oxygen for certain metabolic reactions, it is inevitable to produce some unstable substances, which are all "transformations" of oxygen. Their personality is very lively, they do not like to stay in place safely, and even like to attack others. Due to their lack of restraint, they are called free radicals. The unrestrained personality of free radicals can be a headache, but sometimes the human body needs to eliminate certain invading microorganisms or abnormal cells through the activity of free radicals. Therefore, lively free radicals also have their lovely side. When the concentration of free radicals in the human body is not very high, the body has a complete system to eliminate these free radicals, which is called the antioxidant system. However, unfortunately, the space and form of life can greatly increase the concentration of free radicals in the body, such as smoking, air pollution, water pollution, radiation, insecticides, high living pressure, excessive exercise, etc. These situations that can increase the concentration of free radicals are called oxidative stress. The greater the oxidative pressure, the higher the concentration of free radicals in the body, and at this point, the antioxidant system in the body will face a crisis of insufficient use.

Desert living cistanche—Antioxidant

Effects Of Cistanche—Antioxidant

Having antioxidant activity refers to any oxidation reaction that can effectively inhibit free radicals when present at low concentrations. Its mechanism of action can be direct action on free radicals or indirect consumption of substances that are prone to generating free radicals, preventing further reactions from occurring. More and more studies have shown that antioxidant activity is an important step in preventing aging, as free radicals or oxidants can decompose cells and tissues, affect metabolic function, and cause different health problems. If excessive oxidative free radicals can be eliminated, it can prevent many diseases caused by free radicals and aging-related diseases. For example, common cancers, Arteriosclerosis, diabetes, cataracts, cardiovascular diseases, senile dementia, arthritis, etc. are all considered to be related to free radicals. Therefore, more and more anti-oxidation and anti-aging health products are favored, and Cistanche deserticola is also highly praised for its anti-oxidation effect.

Benefits of cistanche tubulosa—Antioxidant

Benefits of cistanche tubulosa—Antioxidant

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Li Linlin and other researchers have shown that the total glycosides of Cistanche deserticola can enhance the activities of selenium Glutathione peroxidase and SOD (Superoxide dismutase) in the brain, serum, and liver of aging organisms, reduce the content of lipid peroxide and lipofuscin in the heart and brain system, produce an antioxidant effect on the body tissues, and protect the body from acute Cerebral hypoxia and myocardial damage. 

Desert ginseng—Antioxidant

Cistanche tea—Antioxidant

The Phenethyl alcohol glycosides in Cistanche deserticola deserticola have a strong ability to scavenge DPPH (1,1-diphenyl-2-trinitrophenylhydrazine) free radicals, thus exerting a good antioxidant capacity. Ergosteroside inhibits D-Gal (D-Amino Galactose) and LPS (Lipopolysaccharide) induced liver death by scavenging reactive oxygen free radicals in the body. Cistanche deserticola glycoside B in Xinjiang also has a similar effect, which can protect DNA damage caused by peroxidation by reducing the accumulation of intracellular reactive oxygen free radicals induced by MPP+. The total glycosides of Phenethyl alcohol contain multiple phenolic hydroxyl groups in the molecule, which can combine with free radicals in the body, thus avoiding the accumulation of free radicals in the body, protecting the body from peroxidation damage, and are the main Active ingredient of anti-aging and antioxidant effects. Research shows that Cistanche deserticola can delay the aging of animal skin by increasing the content of hydroxyproline, collagen fiber, and skin elasticity.

Cistanche deserticola experiment

Experimental Study on Cistanche deserticola

With the improvement of people's health awareness, the antioxidant effect of Cistanche deserticola has gradually become popular, which greatly promotes the research and development of clinical drugs, health products, and cosmetics of Cistanche deserticola, and also increases its market share in the field of traditional Chinese medicine health products and traditional Chinese medicine.

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