Forward Application Of Deserticola in COVID-19 Diagnosis And Treatment

Contact: emily.li@wecistanche.com

Cistanche has the effect of boosting immunity and moistening bowel in COVID-19

Abstract: Novel coronavirus (COVID-19) has now shown a severe global pandemic and has had a huge impact on human politics, economy, and study and life. With the deepening of COVID-19 cognition, China has proposed targeted diagnosis and treatment programs. As a valuable medicinal material, deserticola has a history of use for more than 2000 years. According to the existing research data in academic circles, it can be believed that bowel defecation and immune regulation function has been of certain clinical significance to patients in the rehabilitation period.

Key words: deserticola; novel coronavirus; rehabilitation

Cistanche deserticola have many effects, click here to know more

Application of Cistanche in the Field of Treatment of COVID-19: a Foresight

Abstract: The coronavirus disease (COVID-19) has presented a severe global pandemic and has had a huge impact on human politics, economy, and learning life. With the continuous deepening of the recognition of COVID-19, China has proposed targeted diagnosis and treatment programs. Cistanche has been used as a valuable medicinal material for more than 2000 years. According to the existing research, it could be considered that the intestinal laxative and immunomodulatory functions of Cistanche deserticola have clinical significance for patients with COVID-19 in rehabilitation.

Keywords: cistanche; COVID-19; rehabilitation

As of June 13,2020,7.4 million patients with novel coronavirus worldwide, causing about 420,000 deaths, according to new WHO statistics[1]Although under the leadership of the Party and government, COVID-19 was effectively contained in the mainland, Hong Kong, Macao, and Taiwan, due to the differences between cultural and political systems in other countries, COVID-19 failed to get effective control in other countries, which has shown the global pandemic. On June 10, 2020, the top international journal Nature 》 published Remdesivir on the treatment of novel coronavirus, reporting that early infection was of clinical significance, but the authors also said the results were questionable due to differences between rhesus monkeys and humans[2]Meanwhile, China and the world are vigorously developing vaccines against COVID-19, but not yet.

Vaccines are on the market.

According to the State Administration of Traditional Chinese Medicine, the efficiency of integrated traditional Chinese and western medicine treatment can reach more than 92%, so it can be predicted that Chinese medicinal materials have certain application value and practical significance in the prevention and control of COVID-19. Cao and other systems summarize the progress of traditional Chinese medicine in the prevention and control of COVID-19, believing that plant polysaccharide is an effective ingredient in the fight against novel coronavirus[3]. The National Health Commission clarified the TCM diagnosis and treatment plan for Novel Coronavirus (Trial Sixth Edition) (hereinafter referred to as the plan), which divided the diagnosis and treatment plan into 7 categories according to the development and degree of the condition, including a variety of traditional Chinese medicine. deserticola has been used as a medicinal material for more than 2000 years. Since the Classic of the Eastern Han Dynasty, Shennong Materia Medica in various dynasties.

They are collected as precious medicinal materials. According to the Shennong Materia Medica Classic in the Eastern Han Dynasty, deserticola was " salty. The main treatment of five labor seven injuries, repair, in addition to the stem cold and pain, raise five viscera, strong Yin, essence qi, many children, women abdomen (sound contend for armor). Take along the light body, raw valley." Li Shizhen is in the"Compendium of Materia Medica" records deserticola as " sweet, slightly warm and non-toxic. The master cure labor injury, face black." Although deserticola is not included in the protocol, the physiological activity of deserticola allows it to be considered as an alternative for patients in the rehabilitation stage.

1. Relieve Intestinal defecation

The plan is clear that patients in the recovery stage have the symptoms of stool weakness, while cisticola has a certain laxative effect. Fan Yanan prepared a mouse constipation model through loperamide hydrochloride, applied the total side of deserticola and deserticola, then the animal defecation and the physiological indicators in mice were studied and parallel comparison found that deserticola is the main active ingredient of deserticola[5]According to the comprehensive literature, combined with the symptoms of patients in the rehabilitation stage, it can be believed that deserticola facilitates the recovery of intestinal health.

2. Immunoregulation

For the common situation of respiratory failure, the protocol believes that mechanical ventilation should be given. Bronchiotomy intubation lien is one of the common clinical operations to relieve patients ' breathing difficulties and is also an important rescue technology in first aid work. Wen Guohua and others believe that tracheotomy intubation lien has a certain necessity in the process of Coronavirus treatment[5]However, it is worth noting that the operation inevitably destroys the defense function of patients' respiratory tract, and then easily cause lung reinfection, although antibiotics can be used to effectively control the patient condition, the plan states that the blind or inappropriate use of antibiotics, especially the joint use of broad-spectrum antibiotics.

Yao Jinxi with cisticola polysaccharide solution to tracheotomy intubation lien mice administration, relative to the control group, administration mice lung slice lesions showed obvious improvement trend, combining the research results, the author believes that deserticola can improve the immunity of tracheotomy intubation lien patients, and produce a positive effect on lung infection, produce the main component of improving immune function for deserticola polysaccharide[7]。

The application of cisticola to prevent lung injury was flourishing. Yin Gang and other studies found that the extract of cisticola can effectively reduce lung damage caused by infection. The author believes that the protective effect of cisticola extract on dosage from lung injury and inhibit lung migration of inflammatory cells, promote the synthesis of nucleic acid and protein while enhancing phagocytosis

Immune function and other ways related[8]The research group also studied the protective effect of deserticola for acute lung injury caused by sepsis, which showed that it also had a clear protective effect[8]In addition, several studies show that deserciticola has clear lung protection on acute lung injury and plateau pulmonary edema in rats due to lipopolysaccharides, but Mao Xinmin and Liu Tao believe that the mechanism of cisticola preventing lung injury is the anti-inflammatory and anti-oxygen compounds of benzene, one of its effective components stress activity.

Zhao and others studied deserticola polysaccharide as a vaccine adjuvant, found that deserticola polysaccharide can improve the humoral immune response and cellular immune response of influenza virus vaccine, the author believes that deserticola polysaccharide as a vaccine has certain feasibility and safety as an adjuvant[12]The active ingredient of traditional Chinese medicine is one of the hot spots in the research field of traditional Chinese medicine[13] Advax, a polysaccharide adjuvant derived from inulin, has conducted several clinical trials covering various viral infectious diseases such as HIV, influenza and hepatitis B[14]Therefore, it can be considered that the polysaccharide for the development of COVID-19 vaccine.

3. Anti-fatigue

Li Yongchao found that cisticola has a clear anti-fatigue effect, its main active ingredient is Pthanoside contained in deserticola. The plan indicates that patients in the rehabilitation period feel more tired and weak, so taking deserticola as a diet plan can relieve this symptom.

To sum up, patients with infection with novel coronavirus in the rehabilitation period including shortness of breath, fatigue and stool weakness, and deserticola as a precious medicinal material, has a history of more than 2000 years, according to the literature, deserticola polysaccharide has immune regulation and defecation, so it has certain clinical significance for patients. At present, a number of COVID-19 patients confirmed in Fengtai District, Beijing, China, are mostly related to the Xinfadi wholesale market. It can be predicted that the fight against novel coronavirus will be normal. In daily life, citizens should not only be encouraged to pay attention to health but also to do a good job in the virus prevention and control of susceptible groups. As a traditional Chinese medicine with similar medicine and food, it can be eaten appropriately in daily life, so as to improve personal immunity and is of certain significance to future epidemic prevention work.

References

[1] World Health Organization

[2] Williamson B.N., Feldmann F., Schwarz B., et al. Clinical benefit of redelivering in rhesus macaques infected with SARS-CoV-2. Nature (2020). https://doi.org/10.1038/ s41586-020-2423-5.

[3] Peng C, Scanlan W, Tingting W, et al. The important role of polysaccharides from a traditional Chinese medicine lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic[J]. Carbohydrate Polymers, 240.

[4] COVID-19 Treatment Plan of General Office of National Health Commission (Trial 6th Edition) [EB/OL]. 2020,(2020-02-18).

[5] Fan Yanan, Wang Jia, Jia Tianzhu, Different effects of deserticola on defecation of constipation [J] Journal of Pharmacy, 2017,37 (13): 1256-1258

[6] Zhang Yanshu, Cai Yunhui, Zhou Guangquan, preliminary experience and experience of tracheotomy in critically ill COVID-19 patients (with 1 case report) [J]. Chinese Journal of Integrated Traditional Chinese and Western Medicine, 2020,28 (02): 100-102 + 92.

[7] Effect of deserticola on immune function of the lung of tracheotomy intubation in rats [D]. Guangxi Medical University, 2019

[8] Effects of Yin Gang, Wang Zhiqiang, Huang deserticola on Acute Lung Injury in rats with septic shock [J]. Journal of Traditional Chinese Medicine, 2004 (03): 62-64 + 84:

[9] Yin Gang, Wang Guilin, Yu Wengui rhubarb and deserticola extract to sepsis

Effect of lung injury in the shock model rat [J]. Chinese ethnic folk medicine, 2009,18 (20): 11-12]

[10]Tao Yichen, Li Jianying, Xu Yonghua, Prevention, and control activities of TCM on plateau pulmonary edema in rats [J] Chinese Journal of Experimental Medicine, 2014,20 (15): 134-138

[11] By Shuping, Wang Bo, Zhao Jun, et al. Effect of the total ethanol glycoside of deserciticol on acute lung injury induced by deoxyglucose in rats [J]. Chinese Journal of Pharmacology and Toxicology, 2019,33 (05): 347-353

[12] Zhao B,Lian J,Wang D, et al Evaluation of aqueous extracts of cistanche deserticola as a polysaccharide adjuvant for seasonal influenza vaccine in young adult mice[J]. Elsevier,2019,213 (C).

[13] Zhu Zhe, Cai Hongzhi, Li Jinbo Research Progress of Chinese herbal extract as a vaccine adjuvant [J]. Journal of Medical Research, 2018,47 (05): 7-10

[14] Clinical Trials.

[15] Study on fatigue mechanism of deserticola Li Yongchao [D]. China Union Medical University, 2007