How Cistanche Protect The Liver?

What is the way to protect the liver?

Contact: emily.li@wecistanche.com

Keywords: liver, cistanche, acute liver injury.

The liver is one of the important organs of the human body, which plays a vital role in human health. If there is a problem with the liver, the toxins in the body cannot be discharged normally, which may cause a variety of diseases over time. So, what is the good method that raises liver in the life?

1. Pharmacological liver protection - Cistanche

Cistanche has a great effect on protecting the liver. Cistanche has a variety of pharmacological activities such as protecting ischemic myocardium, lowering blood lipids, anti-atherosclerosis and anti-thrombosis, reducing peripheral vascular resistance, lowering blood pressure, anti-fatty liver, and anti-tumor.

The mechanism of protecting the liver is about three areas.

• The first step is to renew liver cells

Scientific research has confirmed that the effect of Cistanche tubulosa in repairing and renewing liver cells is mainly through the functional component in its extract-echinacoside

Reduce the activity levels of alanine aminotransferase (ALT) and aspartate transferase (AST) in the serum of damaged liver (in liver function tests, alanine aminotransferase is an indicator of liver cell damage, while aspartate transferase reflects the standard of hepatocyte necrosis);

Improve the activity of superoxide dismutase (SOD); and through the functional component of its extract-verbascoside, it can effectively remove superoxide free radicals in the body (the harmful compounds produced in the body's oxidation reaction). It has strong oxidizing properties and can damage The tissues and cells of the body, which in turn cause chronic diseases and aging effects), so as to achieve the protection and treatment of liver damage.

• The second step is to protect liver cells

The protective effect of Cistanche on primary cultured hepatocytes is mainly through the symbolic component in its extract-Cistanche total glycosides increase the expression of apoptosis-suppressing genes (Bcl-2 gene belongs to a new class of oncogene family members. It can effectively inhibit apoptosis induced by many different types of apoptosis stimuli in many different types of cells, and prolong cell viability. Learning function);

Reduce the expression of pro-apoptotic genes to reduce cell apoptosis and necrosis, and increase cell survival. At the same time, it plays a role in reducing the activity of LDH5, increasing the content of liver glycogen in load exercise, and promoting the synthesis of liver glycogen.

• The third step is to "detoxify" liver cells
  

The disorder of body function is bound to be accompanied by the disorder of cell function. The amount of "toxin" exceeds the processing capacity of the cell, and the body organs will be "poisoned."

The detoxification and detoxification effect of Cistanche is mainly achieved by inhibiting the NADPH-CCl4 induced lipid peroxidation in hepatocyte microsomes and the release of aspartate aminotransferase in cells, which is the symbolic component of the extract-Cistanche total glycosides. CCl4 (carbon tetrachloride) and D-GalN (D-galactosamine) induce hepatotoxicity, and at the same time accelerate the liver's catabolism of alcohol, and provide the liver cells with the nutrients needed for their growth and proliferation. Nourish the purpose.

Cistanche can protect the liver and improve liver function.

2. Eat balanced diets, drink more water

Diet should be balanced, protein, carbohydrate, fat, vitamins, minerals, etc. in food should be maintained in proportion; At the same time, we should keep the five flavors balanced and try to eat less spicy food. A reasonable diet, balanced nutrition is also conducive to protecting the liver, avoiding excessive drinking because social activities damage the liver.

Drinking more water can supplement body fluids, enhance blood circulation, promote metabolism, drink more water can also promote glands, especially digestive glands and pancreatic fluid, bile secretion, for digestion, absorption, and waste elimination, reduce the damage of metabolites and toxins to the liver.

3. Eat before you drink

The recipe for drinking involves eating before drinking. Less alcohol naturally less harm, if you must drink, and want to do some preventive measures, that is to eat as much food as possible to pad the stomach, food can form a protective film on the stomach mucosa, intestinal mucosa, not only protect the stomach but also prevent part of the alcohol into the blood, reduce the degree of drunkenness.

The phenoxyethanol glycosides in Cistanche have strong biological activity and significant pharmacological effects. He protects liver cells and treats liver injury through anti-oxidant free radical damage, reducing inflammation and the production of related mediators, improving liver function, improving microcirculation, and regulating immune function. Experimental research on the treatment of liver injury with traditional Chinese medicine will promote the development and clinical application of new traditional Chinese medicines.

Summary

The liver is an important organ for the metabolism and biotransformation of the body. Cistanche has a certain protective effect on the liver. Hepatic fibrosis has become one of the major causes of death from liver disease, which is caused by dysregulation of extracellular matrix degradation and synthesis. Hepatic stellate cells were cultured in rats, and the 50% inhibition rate, cell proliferation, and protein expression were measured by giving different concentrations of total ethanol glycosides of Cistanche in vitro. The results showed that total ethanol glycosides of cistanche could inhibit cell proliferation and protein expression, which indicated that total ethanol glycosides of cistanche had anti-liver fibrosis and good liver protection function. Experimental results showed that cistanche phenylethanoid glycoside could significantly reduce the degree of liver fibrosis in immune rats, and the mechanism might be that the activation of hepatic stellate cells was inhibited, and collagen generation was reduced by reducing the expression of type ⅰ and type ⅲ collagen. Mice were given carbon tetrachloride to induce liver injury and then given total cistanche glycosides to the mice. The results showed that total cistanche glycosides could significantly improve the energy metabolism of mice with liver injury caused by carbon tetrachloride. Carbon tetrachloride was used to cause acute liver injury in mice, and the serum of the mice was detected by cistanche polysaccharides. Experiments showed that cistanche polysaccharides can protect mice from acute liver injury. The results showed that total cistanche glycosides could protect against the damage of primary cultured mouse hepatocytes caused by alcohol.