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07
Dec, 2023
An MRNA Vaccine Elicits STING-dependent Antitumor Immune Responses
Abstract Lipid-formulated RNA vaccines have been widely used for disease prevention and treatment, yet their mechanism of action and individual components contributing to such actions remain to be ...
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27
Nov, 2023
CAR-neutrophil Mediated Delivery Of Tumor Microenvironment Responsive Nanodru...
Glioblastoma (GBM) is one of the most aggressive and lethal solid tumors in humans. While efficacious therapeutics, such as emerging chimeric antigen receptor (CAR)-T cells and chemotherapeutics, h...
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14
Nov, 2023
Pyroptosis At The Forefront Of Anticancer Immunity
Abstract Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two major contributors to poor therapeutic responses during cancer intervention. Pyroptosis, a lytic and ...
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09
Nov, 2023
Lipoxidation And Cancer Immunity
ABSTRACT Lipoxidation is a well-known reaction between electrophilic carbonyl species, formed during the oxidation of lipids, and specific proteins that, in most cases, cause an alteration in prote...
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07
Nov, 2023
Gut Microbiota-mediated Immunomodulation in Tumor
Abstract Tumor immunity consists of various types of cells, which serve an important role in antitumor therapy. The gastrointestinal tract is colonized by trillions of microorganisms, which form th...
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06
Nov, 2023
SINGLE-CELL RNA-SEQ REVEALS THE CRITICAL ROLES OF THE STING- AND MDA5-MEDIATE...
Background Oncolytic viruses are promising therapeutic agents for advanced cancers because of their ability to induce antitumor innate and adaptive immunity. Modified vaccinia virus Ankara (MVA) is...
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27
Oct, 2023
Transposable Element RNA Dysregulation in Mutant KRAS(G12C) 3D Lung Cancer Sp...
ABSTRACT Mutant KRAS regulates transposable element (TE) RNA and interferon-stimulated gene (ISG) expression, but it remains unclear whether diverse mutations in KRAS affect different TE RNAs throu...
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26
Oct, 2023
Manganese(II) Complexes Stimulate Antitumor Immunity Via Aggravating DNA Dama...
Activating the cyclic GMP-AMP synthase-stimulator of the interferon gene (cGAS-STING) pathway is a promising immunotherapeutic strategy for cancer treatment. Manganese(II) complexes MnPC and MnPVA ...
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25
Oct, 2023
BCAT2 Shapes A Noninflamed Tumor Microenvironment And Induces Resistance To A...
To improve the response rate of monotherapy of immune checkpoint blockade (ICB), it is necessary to find an emerging target in combination therapy. Through analyzing tumor microenvironment (TME)-re...
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19
Oct, 2023
β3-adrenergic Receptor On Tumor-infiltrating Lymphocytes Sustains IFN-γ-depen...
Neuroblastoma (NB) is a heterogeneous extracranial tumor occurring in childhood. A distinctive feature of NB tumors is their neuroendocrine ability to secrete catecholamines, which in turn, via β-a...
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17
Oct, 2023
Intratumor Childhood Vaccine-specific CD4+ T-cell Recall Coordinates Antitumo...
ABSTRACT Background Antitumor mechanisms of CD4+ T cells remain crudely defined, and means to effectively harness CD4+ T-cell help for cancer immunotherapy are lacking. Pre-existing memory CD4+ T c...
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09
Oct, 2023
Tumor Cells Fail To Present MHC-II–restricted Epitopes Derived From Oncogenes...
CD4+ T cells play a critical role in antitumor immunity via recognition of peptide antigens presented on MHC class II (MHC-II). Although some solid cancers can be induced to express MHC-II, the ext...