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01
Jul, 2024
Do You Know? Middle Aged And Elderly People Over 60 Years Old Should Suppleme...
After reaching the age of 60, the functions of various organs in the human body will gradually decline. I believe many people may have encountered such a problem, which is that as they age, their m...
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29
Feb, 2024
Kick Away Breast Cancer, Happiness Is Like Flowers
In recent years, breast cancer has become the killer of urban women's health in China. In the three major cities of Beijing, Shanghai, and Guangzhou, the incidence of breast cancer ranks first ...
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25
Dec, 2023
Intimate Communications Within The Tumor Microenvironment: Stromal Factors Fu...
Abstract Extensive studies of the tumor microenvironment (TME) in the last decade have reformed the view of cancer as a tumor cell-centric disease. The tumor microenvironment, especially termed the...
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15
Dec, 2023
Senescence Rewires Microenvironment Sensing To Facilitate Antitumor Immunity
ABSTRACT Cellular senescence involves a stable cell-cycle arrest coupled with a secretory program that, in some instances, stimulates the immune clearance of senescent cells. Using an immune-compet...
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14
Dec, 2023
Metabolic Interventions in Tumor Immunity: Focus On Dual Pathway Inhibitors
Simple Summary: Metabolic reprogramming is one of tumor and immune cells' most significant metabolic alterations. Moreover, metabolic-related signaling pathways, such as phosphoinositide 3-kinases ...
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08
Dec, 2023
Effect Of Proton Therapy On Tumor Cell Killing And Immune Microenvironment Fo...
Abstract : Radiotherapy with proton therapy (PT) has dosimetric advantages over photon therapy, which helps to enlarge the therapeutic window of radiotherapy for hepatocellular carcinoma (HCC). We ...
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07
Dec, 2023
An MRNA Vaccine Elicits STING-dependent Antitumor Immune Responses
Abstract Lipid-formulated RNA vaccines have been widely used for disease prevention and treatment, yet their mechanism of action and individual components contributing to such actions remain to be ...
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27
Nov, 2023
CAR-neutrophil Mediated Delivery Of Tumor Microenvironment Responsive Nanodru...
Glioblastoma (GBM) is one of the most aggressive and lethal solid tumors in humans. While efficacious therapeutics, such as emerging chimeric antigen receptor (CAR)-T cells and chemotherapeutics, h...
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14
Nov, 2023
Pyroptosis At The Forefront Of Anticancer Immunity
Abstract Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two major contributors to poor therapeutic responses during cancer intervention. Pyroptosis, a lytic and ...
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09
Nov, 2023
Lipoxidation And Cancer Immunity
ABSTRACT Lipoxidation is a well-known reaction between electrophilic carbonyl species, formed during the oxidation of lipids, and specific proteins that, in most cases, cause an alteration in prote...
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07
Nov, 2023
Gut Microbiota-mediated Immunomodulation in Tumor
Abstract Tumor immunity consists of various types of cells, which serve an important role in antitumor therapy. The gastrointestinal tract is colonized by trillions of microorganisms, which form th...
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06
Nov, 2023
SINGLE-CELL RNA-SEQ REVEALS THE CRITICAL ROLES OF THE STING- AND MDA5-MEDIATE...
Background Oncolytic viruses are promising therapeutic agents for advanced cancers because of their ability to induce antitumor innate and adaptive immunity. Modified vaccinia virus Ankara (MVA) is...