Effects Of Cistanche On Urination in Normal And Kidney-yang Deficiency Rats

Shen Lianzhong Zhong Xiaoyan Wang Shuxian

(Pharmacology Department, National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050‚ 1 Drug Certification Management Center of the State Drug Administration)

Contact: joanna.jia@wecistanche.com / WhatsApp: 008618081934791

Abstract

Objective: To observe the effect of Cistanche on the urination of male normal rats and "kidney-yang deficiency" rats.

Method: Give normal male rats once with ig Cistanche, collect and measure urine output at different times after administration; use im hydrocortisone to create a "kidney yang deficiency" rat model, simultaneously continuous in Cistanche, collect and measure after the last administration Urinary volume at different times after administration, and weigh the body weight and the weight of the internal organs.

Results: In male normal rats, once in Cistanche cistanche 10g/kg and 20g/kg significantly increased the urine output of 0～1h and 1～2h after administration. Contrary to the effect on normal rats. Give rats continuous in Cistanche for 10 days. Significantly reduce the "Kidney Yang Deficiency" rats 0～1h after the last administration. Within 1～2h, the urine output will increase, and increase the "Kidney Yang Deficiency" The weight of the rat and the weight of some organs. Conclusion: Cistanche has different regulating effects on the urination of normal rats and "kidney-yang deficiency" rats.

Keywords Cistanche; urination; hydrocortisone

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Cistanche deserticola (Cistanche deserticola Y.C. Ma) is the fleshy stem of Cistanche deserticola, a traditional nourishing and aphrodisiac medicine. It has the effects of nourishing the kidney, nourishing essence and moisturizing the intestines. It is called the essential medicine for nourishing the essence and blood and nourishing the kidney in the Book of Materia Medica. It has a good effect on the symptoms of fatigue, forgetfulness, hearing loss, and enuresis caused by kidney deficiency. Cistanche is also used in the folk to treat senile urinary disorder (frequent urination, urinary frequency, urination). Urgency, dripping urine, etc.). Modern studies have shown that Cistanche has a certain anti-aging effect[1‚2], and its total extract has the functions of enhancing the body's immune function[3‚4] and inhibiting lipid peroxidation[4‚5]. There have been experimental research reports on the aphrodisiac effect of Cistanche cistanche [6], but there is no report of its effect on animal urination. This article discusses its effect on urination in rats with "Kidney Yang Deficiency".

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Discuss

Traditional Chinese medicine believes that "the kidney governs water" the bladder's gasification, triple energizing, and water excretion functions all depend on the temperature of the kidney. Uncontrollable urinary (frequent urination, urgency, incessant urination, nocturia, etc.) is caused by insufficient kidney yang, deficiency, and coldness of the lower Jiao, which is more common in middle-aged and elderly patients. Therefore, the treatment of uncontrolled urinary control should be based on warming the kidney-yang. After intramuscular injection of hydrocortisone in rats, an obvious "kidney yang deficiency" model was created: weight loss, adrenal and gonadal coefficients were significantly reduced, etc., and the converted urine output in the 0~1h (the animal weight difference between each group is significant ‚Therefore, it needs to be converted according to body weight.) Compared with the normal control group, it has increased. Cistanche has obvious resistance to weight loss, decreased adrenal and gonadal coefficients, and other symptoms of "kidney yang deficiency". The urinary output of the two-dose groups of Cistanche in 0～1h and 1～2h after administration is more obvious than that of the "kidney yang deficiency" group Less and has a certain negative dose correlation. The urinary output of the Cistanche 10g/kg group at 2～4h and 4～6h was higher than that of the hydrocortisone group, which may be caused by the weakening of the drug effect.

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The results of the study with normal rats showed that “cistanche has the effect of promoting urination in normal rats. This is consistent with our previous report [7] that Cistanche promotes the emptying of bladder urine, and is more effective than the effect of “Kidney Yang Deficiency”. The results of mice urination are the opposite.

Cistanche has two completely different effects on the urination of normal rats and "kidney yang deficiency" rats. First, it should be explained from the increase in urination of rats after "kidney yang deficiency": rats im caused by hydrocortisone "Kidney Yang Deficiency", there has been an increase in urine output. This may be consistent with some symptoms of clinical urinary out-of-control. Cistanche cistanche reduces the urine output of animals with "kidney yang deficiency". This is consistent with traditional Chinese medicine that Cistanche has the effect of warming and nourishing kidney yang. Of course, whether the increase in urine output caused by hydrocortisone in rats with "kidney yang deficiency" is related to clinical urinary out-of-control symptoms? Further tests are needed to confirm. If the results are positive, this may also be a good animal with out-of-control urinary disorders in Chinese medicine. Pharmacological model. Secondly, the promotion effect on normal animals. Although the animals used are awake rats, the state is different from the anesthetized rats used in previous reports [7]. These two tests are whole animals, acute short-term tests, so they are effective The mechanism should be consistent, and the same result is expected. Cistanche has two opposite effects on different animals (one is normal and the other is a sick animal model). This may also be proof that traditional Chinese medicine pays attention to differentiation and treatment.

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References

1 Xue Dejun‚ Zhang Ming‚ Wu Xiaohong‚ et al. Chinese Journal of Traditional Chinese Medicine‚ 1995; 20(10): 687

2 Li Qiaoru‚ Li Shilan‚ Shanghai Journal of Traditional Chinese Medicine‚ 1990; (11): 22

3 Gao Haiqian‚ Research on Chinese Patent Medicine‚ 1984; 23( 9): 34

4 Shi Dawen‚ He Songchun‚ Jiang Ying‚ et al. Journal of Shanghai Medical University‚ 1995; 22(4): 306

5 Wang Xiaowen‚ Li Linlin‚ Muhu Yati‚ etc.• China Journal of Chinese Materia Medica‚ 1998; 23(9): 554

6 He Wei‚ Shu Xiaofen‚ Zong Guizhen‚ et al. Chinese Journal of Chinese Materia Medica‚ 1996; 21(9): 534

7 Shen Lianzhong‧ Zhong Xiaoyan‚ Wang Shuxian• New Chinese Medicine and Clinical Pharmacology‚ 1999; 10(2): 82～83