Influence Of The Mediterranean Diet On Healthy Aging Part 5
Jun 30, 2023
Reference cont.
186. Jung, C.H.; Ro, S.H.; Cao, J.; Otto, N.M.; Kim, D.H. MTOR Regulation of Autophagy. FEBS Lett. 2010, 584, 1287–1295. [CrossRef]
187. Khanfar, M.A.; Bardaweel, S.K.; Akl, M.R.; El Sayed, K.A. Olive Oil-Derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies. Phytother. Res. PTR 2015, 29, 1776–1782. [CrossRef]
Glycoside of cistanche can also increase the activity of SOD in heart and liver tissues, and significantly reduce the content of lipofuscin and MDA in each tissue, effectively scavenging various reactive oxygen radicals (OH-, H₂O₂, etc.) and protecting against DNA damage caused by OH-radicals. Cistanche phenylethanoid glycosides have a strong scavenging ability of free radicals, a higher reducing ability than vitamin C, improve the activity of SOD in sperm suspension, reduce the content of MDA, and have a certain protective effect on sperm membrane function. Cistanche polysaccharides can enhance the activity of SOD and GSH-Px in erythrocytes and lung tissues of experimentally senescent mice caused by D-galactose, as well as reduce the content of MDA and collagen in lung and plasma, and increase the content of elastin, have a good scavenging effect on DPPH, prolong the time of hypoxia in senescent mice, improve the activity of SOD in serum, and delay the physiological degeneration of lung in experimentally senescent mice With cellular morphological degeneration, experiments have shown that Cistanche has the good antioxidant ability and has the potential to be a drug to prevent and treat skin aging diseases. At the same time, echinacoside in Cistanche has a significant ability to scavenge DPPH free radicals and has the ability to scavenge reactive oxygen species and prevent free radical-induced collagen degradation, and also has a good repair effect on thymine free radical anion damage.
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188. Jemai, H.; Feki, A.E.L.; Sayadi, S. Antidiabetic and Antioxidant Effects of Hydroxytyrosol and Oleuropein from Olive Leaves in Alloxan-Diabetic Rats. J. Agric. Food Chem. 2009, 57, 8798–8804. [CrossRef]
189. Al-Azzawie, H.F.; Alhamdani, M.S.S. Hypoglycemic and Antioxidant Effect of Oleuropein in Alloxan-Diabetic Rabbits. Life Sci. 2006, 78, 1371–1377. [CrossRef]
190. Camandola, S.; Mattson, M.P. Brain Metabolism in Health, Aging, and Neurodegeneration. EMBO J. 2017, 36, 1474–1492. [CrossRef]
191. Cai, H.; Cong, W.; Ji, S.; Rothman, S.; Maudsley, S.; Martin, B. Metabolic Dysfunction in Alzheimer’s Disease and Related Neurodegenerative Disorders. Curr. Alzheimer Res. 2012, 9, 5–17. [CrossRef]
192. Runchey, S.S.; Pollak, M.N.; Valsta, L.M.; Coronado, G.D.; Schwarz, Y.; Breymeyer, K.L.; Wang, C.; Wang, C.Y.; Lampe, J.W.; Neuhouser, M.L. Glycemic Load Effect on Fasting and Post-Prandial Serum Glucose, Insulin, IGF-1, and IGFBP-3 in a Randomized, Controlled Feeding Study. Eur. J. Clin. Nutr. 2012, 66, 1146–1152. [CrossRef]
193. Levine, M.E.; Suarez, J.A.; Brandhorst, S.; Balasubramanian, P.; Cheng, C.W.; Madia, F.; Fontana, L.; Mirisola, M.G.; GuevaraAguirre, J.; Wan, J.; et al. Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population. Cell Metab. 2014, 19, 407–417. [CrossRef]
194. Fontana, L.; Adelaide, R.M.; Rastelli, A.L.; Miles, K.M.; Ciamporcero, E.; Longo, V.D.; Nguyen, H.; Vessella, R.; Pili, R. Dietary Protein Restriction Inhibits Tumor Growth in Human Xenograft Models of Prostate and Breast Cancer. Oncotarget 2013, 4, 2451. [CrossRef]
195. Menendez, J.A.; Joven, J.; Aragonès, G.; Barrajón-Catalán, E.; Beltrán-Debón, R.; Borrás-Linares, I.; Camps, J.; Corominas-Faja, B.; Cufí, S.; Fernández-Arroyo, S.; et al. Xenohormetic and Anti-Aging Activity of Secoiridoid Polyphenols Present in Extra Virgin Olive Oil: A New Family of Gerosuppressant Agents. Cell Cycle 2013, 12, 555–578. [CrossRef]
196. Brown-Borg, H.M.; Buffenstein, R. Cutting Back on the Essentials: Can Manipulating Intake of Specific Amino Acids Modulate Health and Lifespan? Ageing Res. Rev. 2017, 39, 87–95. [CrossRef]
197. Lynch, C.J.; Adams, S.H. Branched-Chain Amino Acids in Metabolic Signalling and Insulin Resistance. Nature reviews. Endocrinology 2014, 10, 723–736. [CrossRef]
198. Fontana, L.; Cummings, N.E.; Arriola Apelo, S.I.; Neuman, J.C.; Kasza, I.; Schmidt, B.A.; Cava, E.; Spelta, F.; Tosti, V.; Syed, F.A.; et al. Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health. Cell Rep. 2016, 16, 520–530. [CrossRef]
199. Remmen, H.V.; Richardson, A. Oxidative Damage to Mitochondria and Aging. Exp. Gerontol. 2001, 36, 957–968. [CrossRef]
200. Birnbaum, J.H.; Wanner, D.; Gietl, A.F.; Saake, A.; Kündig, T.M.; Hock, C.; Nitsch, R.M.; Tackenberg, C. Oxidative Stress and Altered Mitochondrial Protein Expression in the Absence of Amyloid-β and Tau Pathology in IPSC-Derived Neurons from Sporadic Alzheimer’s Disease Patients. Stem Cell Res. 2018, 27, 121–130. [CrossRef]
201. Park, J.S.; Davis, R.L.; Sue, C.M. Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives. Curr. Neurol. Neurosci. Rep. 2018, 18, 21. [CrossRef]
202. Kudryavtseva, A.V.; Krasnov, G.S.; Dmitriev, A.A.; Alekseev, B.Y.; Kardymon, O.L.; Sadritdinova, A.F.; Fedorova, M.S.; Pokrovsky, A.V.; Melnikova, N.V.; Kaprin, A.D.; et al. Mitochondrial Dysfunction and Oxidative Stress in Aging and Cancer. Oncotarget 2016, 7, 44879. [CrossRef]
203. Bhatti, J.S.; Bhatti, G.K.; Reddy, P.H. Mitochondrial Dysfunction and Oxidative Stress in Metabolic Disorders—A Step towards Mitochondria Based Therapeutic Strategies. Biochim. Biophys. Acta Mol. Basis Dis. 2017, 1863, 1066–1077. [CrossRef]
204. Kowaltowski, A.J.; de Souza-Pinto, N.C.; Castilho, R.F.; Vercesi, A.E. Mitochondria, and Reactive Oxygen Species. Free Radic. Biol. Med. 2009, 47, 333–343. [CrossRef]
205. Choksi, K.B.; Boylston, W.H.; Rabek, J.P.; Widger, W.R.; Papaconstantinou, J. Oxidatively Damaged Proteins of Heart Mitochondrial Electron Transport Complexes. Biochim. Biophys. Acta Mol. Basis Dis. 2004, 1688, 95–101. [CrossRef]
206. Sowers, J.R. Insulin Resistance and Hypertension. Am. J. Physiol. Heart Circ. Physiol. 2004, 286, H1597-602. [CrossRef]
207. Smith, S.C. Multiple Risk Factors for Cardiovascular Disease and Diabetes Mellitus. Am. J. Med. 2007, 120, S3–S11. [CrossRef]
208. Morino, K.; Petersen, K.F.; Dufour, S.; Befroy, D.; Frattini, J.; Shatzkes, N.; Neschen, S.; White, M.F.; Bilz, S.; Sono, S.; et al. Reduced Mitochondrial Density and Increased IRS-1 Serine Phosphorylation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Parents. J. Clin. Investig. 2005, 115, 3587–3593. [CrossRef]
209. Maassen, J.A.; ’T Hart, L.M.; Van Essen, E.; Heine, R.J.; Nijpels, G.; Jahangir Tafrechi, R.S.; Raap, A.K.; Janssen, G.M.C.; Lemkes, H.H.P.J. Mitochondrial Diabetes: Molecular Mechanisms and Clinical Presentation. Diabetes 2004, 53 (Suppl. S1), S103–S109. [CrossRef]
210. Cooper, S.A.; Whaley-Connell, A.; Habibi, J.; Wei, Y.; Lastra, G.; Manrique, C.; Stas, S.; Sowers, J.R. Renin-Angiotensin-Aldosterone System, and Oxidative Stress in Cardiovascular Insulin Resistance. Am. J. Physiol. Heart Circ. Physiol. 2007, 293, H2009–H2023. [CrossRef]
211. Khalil, M.; Shanmugam, H.; Abdallah, H.; John Britto, J.S.; Galerati, I.; Gómez-Ambrosi, J.; Frühbeck, G.; Portincasa, P. The Potential of the Mediterranean Diet to Improve Mitochondrial Function in Experimental Models of Obesity and Metabolic Syndrome. Nutrients 2022, 14, 3112. [CrossRef]
212. Estruch, R.; Ros, E.; Salas-Salvadó, J.; Covas, M.-I.; Corella, D.; Arós, F.; Gómez-Gracia, E.; Ruiz-Gutiérrez, V.; Fiol, M.; Lapetra, J.; et al. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N. Engl. J. Med. 2018, 378, e34. [CrossRef]
213. Varela-Lopez, A.; Pérez-López, M.P.; Ramirez-Tortosa, C.L.; Battino, M.; Granados-Principal, S.; Ramirez-Tortosa, M.d.C.; Ochoa, J.J.; Vera-Ramirez, L.; Giampieri, F.; Quiles, J.L. Gene Pathways Associated with Mitochondrial Function, Oxidative Stress and Telomere Length Are Differentially Expressed in the Liver of Rats Fed Lifelong on Virgin Olive, Sunflower or Fish Oils. J. Nutr. Biochem. 2018, 52, 36–44. [CrossRef]
214. Quiles, J.L.; Huertas, J.R.; Mañas, M.; Ochoa, J.J.; Battino, M.; Mataix, J. Oxidative Stress Induced by Exercise and Dietary Fat Modulates the Coenzyme Q and Vitamin A Balance between Plasma and Mitochondria. Int. J. Vitam. Nutr. Research. Int. Z. Fur Vitam.-Und Ernahrungsforschung. J. Int. Vitaminol. Nutr. 1999, 69, 243–249. [CrossRef]
215. Ochoa, J.J.; Quiles, J.L.; Ibáñez, S.; Martínez, E.; López-Frías, M.; Huertas, J.R.; Mataix, J. Aging-Related Oxidative Stress Depends on Dietary Lipid Source in Rat Postmitotic Tissues. J. Bioenerg. Biomembr. 2003, 35, 267–275. [CrossRef]
216. Mataix, J.; Ochoa, J.J.; Quiles, J.L. Olive Oil, and Mitochondrial Oxidative Stress. International journal for vitamin and nutrition research. Int. Z. Fur Vitam.-Und Ernahrungsforschung. J. Int. Vitaminol. Nutr. 2006, 76, 178–183. [CrossRef]
217. Barja, G. Rate of Generation of Oxidative Stress-Related Damage and Animal Longevity. Free Radic. Biol. Med. 2002, 33, 1167–1172. [CrossRef]
218. Brown-Borg, H.M.; Rakoczy, S.G. Catalase Expression in Delayed and Premature Aging Mouse Models. Exp. Gerontol. 2000, 35, 199–212. [CrossRef]
219. Beckman, K.B.; Ames, B.N. The Free Radical Theory of Aging Matures. Physiol. Rev. 1998, 78, 547–581. [CrossRef] [PubMed]
220. Sun, W.; Wang, X.; Hou, C.; Yang, L.; Li, H.; Guo, J.; Huo, C.; Wang, M.; Miao, Y.; Liu, J.; et al. Oleuropein Improves Mitochondrial Function to Attenuate Oxidative Stress by Activating the Nrf2 Pathway in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats. Neuropharmacology 2017, 113, 556–566. [CrossRef]
221. Schaffer, S.; Podstawa, M.; Visioli, F.; Bogani, P.; Müller, W.E.; Eckert, G.P. Hydroxytyrosol-Rich Olive Mill Wastewater Extract Protects Brain Cells in Vitro and Ex Vivo. J. Agric. Food Chem. 2007, 55, 5043–5049. [CrossRef] [PubMed]
222. Peng, Y.; Hou, C.; Yang, Z.; Li, C.; Jia, L.; Liu, J.; Tang, Y.; Shi, L.; Li, Y.; Long, J.; et al. Hydroxytyrosol Mildly Improves Cognitive Function Independent of APP Processing in APP/PS1 Mice. Mol. Nutr. Food Res. 2016, 60, 2331–2342. [CrossRef] [PubMed]
223. Camilleri, A.; Vassallo, N. The Centrality of Mitochondria in the Pathogenesis and Treatment of Parkinson’s Disease. CNS Neurosci. Ther. 2014, 20, 591–602. [CrossRef]
224. Lin, M.T.; Beal, M.F. Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases. Nature 2006, 443, 787–795. [CrossRef] [PubMed]
225. Martín, S.; González-Burgos, E.; Carretero, M.E.; Gómez-Serranillos, M.P. Neuroprotective Properties of Spanish Red Wine and Its Isolated Polyphenols on Astrocytes. Food Chem. 2011, 128, 40–48. [CrossRef] [PubMed]
226. Martín, S.; González-Burgos, E.; Carretero, M.E.; Gómez-Serranillos, M.P. Protective Effects of Merlot Red Wine Extract and Its Major Polyphenols in PC12 Cells under Oxidative Stress Conditions. J. Food Sci. 2013, 78, H112–H118. [CrossRef] [PubMed]
227. Qiu, L.; Luo, Y.; Chen, X. Quercetin Attenuates Mitochondrial Dysfunction and Biogenesis via Upregulated AMPK/SIRT1 Signaling Pathway in OA Rats. Biomed. Pharmacother. 2018, 103, 1585–1591. [CrossRef] [PubMed]
228. Khan, M.M.; Ahmad, A.; Ishrat, T.; Khan, M.B.; Hoda, M.N.; Khuwaja, G.; Raza, S.S.; Khan, A.; Javed, H.; Vaibhav, K.; et al. Resveratrol Attenuates 6-Hydroxydopamine-Induced Oxidative Damage and Dopamine Depletion in Rat Model of Parkinson’s Disease. Brain Res. 2010, 1328, 139–151. [CrossRef]
229. Jardim, F.R.; de Rossi, F.T.; Nascimento, M.X.; da Silva Barros, R.G.; Borges, P.A.; Prescilio, I.C.; de Oliveira, M.R. Resveratrol and Brain Mitochondria: A Review. Mol. Neurobiol. 2018, 55, 2085–2101. [CrossRef]
230. Kurin, E.; Muˆcaji, P.; Nagy, M. In Vitro Antioxidant Activities of Three Red Wine Polyphenols and Their Mixtures: An Interaction Study. Molecules 2012, 17, 14336–14348. [CrossRef] [PubMed]
231. Fernández-Pachón, M.S.; Berná, G.; Otaolaurruchi, E.; Troncoso, A.M.; Martín, F.; García-Parrilla, M.C. Changes in Antioxidant Endogenous Enzymes (Activity and Gene Expression Levels) after Repeated Red Wine Intake. J. Agric. Food Chem. 2009, 57, 6578–6583. [CrossRef]
232. Afshordel, S.; Hagl, S.; Werner, D.; Röhner, N.; Kögel, D.; Bazan, N.G.; Eckert, G.P. Omega-3 Polyunsaturated Fatty Acids Improve Mitochondrial Dysfunction in Brain Aging - Impact of Bcl-2 and NPD-1 like Metabolites. Prostaglandins Leukot. Essent. Fat. Acids 2015, 92, 23–31. [CrossRef]
233. Eckert, G.P.; Lipka, U.; Muller, W.E. Omega-3 Fatty Acids in Neurodegenerative Diseases: Focus on Mitochondria. Prostaglandins Leukot. Essent. Fat. Acids 2013, 88, 105–114. [CrossRef]
234. Chauveau, F.; Cho, T.-H.; Perez, M.; Guichardant, M.; Riou, A.; Aguettaz, P.; Picq, M.; Lagarde, M.; Berthezene, Y.; Nighoghossian, N.; et al. Brain-Targeting Form of Docosahexaenoic Acid for Experimental Stroke Treatment: MRI Evaluation and Anti-Oxidant Impact. Curr. Neurovascular Res. 2011, 8, 95–102. [CrossRef]
235. Karki, K.; Pande, D.; Negi, R.; Khanna, S.; Khanna, R.S.; Khanna, H.D. Correlation of Serum Toll-like Receptor 9 and Trace Elements with Lipid Peroxidation in the Patients of Breast Diseases. J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem. (GMS) 2015, 30, 11–16. [CrossRef]
236. Do Val Carneiro, J.L.; Nixdorf, S.L.; Mantovani, M.S.; Da Silva Do Amaral Herrera, A.C.; Aoki, M.N.; Amarante, M.K.; Fabris, B.A.; Pelegrinelli Fungaro, M.H.; Ehara Watanabe, M.A. Plasma Malondialdehyde Levels and CXCR4 Expression in Peripheral Blood Cells of Breast Cancer Patients. J. Cancer Res. Clin. Oncol. 2009, 135, 997–1004. [CrossRef]
237. Maia, F.M.M.; Santos, E.B.; Reis, G.E. lias Oxidative Stress and Plasma Lipoproteins in Cancer Patients. Einstein 2014, 12, 480–484. [CrossRef]
238. Didžiapetriene, J.; Bubleviˇc, J.; Smailyte, G.; Kazbariene, B.; Stukas, R. Significance of Blood Serum Catalase Activity and Malondialdehyde Level for Survival Prognosis of Ovarian Cancer Patients. Medicina 2014, 50, 204–208. [CrossRef]
239. Chole, R.H.; Patil, R.N.; Basak, A.; Palandurkar, K.; Bhowate, R. Estimation of Serum Malondialdehyde in Oral Cancer and Precancer and Its Association with Healthy Individuals, Gender, Alcohol, and Tobacco Abuse. J. Cancer Res. Ther. 2010, 6, 487–491. [CrossRef]
240. Li, Y.P.; Tian, F.G.; Shi, P.C.; Guo, L.Y.; Wu, H.M.; Chen, R.Q.; Xue, J.M. 4-Hydroxynonenal Promotes Growth and Angiogenesis of Breast Cancer Cells through HIF-1α Stabilization. Asian Pac. J. Cancer Prev. APJCP 2014, 15, 10151–10156. [CrossRef]
241. Moral, R.; Escrich, E. Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms. Molecules 2022, 27, 477. [CrossRef]
242. Rodier, F.; Campisi, J. Four Faces of Cellular Senescence. J. Cell Biol. 2011, 192, 547. [CrossRef]
243. Kuilman, T.; Michaloglou, C.; Mooi, W.J.; Peeper, D.S. The Essence of Senescence. Genes Dev. 2010, 24, 2463–2479. [CrossRef]
244. Von Zglinicki, T.; Wan, T.; Miwa, S. Senescence in Post-Mitotic Cells: A Driver of Aging? Antioxid. Redox Signal. 2021, 34, 308–323. [CrossRef]
245. Tchkonia, T.; Zhu, Y.; Van Deursen, J.; Campisi, J.; Kirkland, J.L. Cellular Senescence and the Senescent Secretory Phenotype: Therapeutic Opportunities. J. Clin. Investig. 2013, 123, 966–972. [CrossRef]
246. Serrano, M.; Lin, A.W.; McCurrach, M.E.; Beach, D.; Lowe, S.W. Oncogenic Ras Provokes Premature Cell Senescence Associated with Accumulation of P53 and P16INK4a. Cell 1997, 88, 593–602. [CrossRef]
247. Krishnamurthy, J.; Torrice, C.; Ramsey, M.R.; Kovalev, G.I.; Al-Regaiey, K.; Su, L.; Sharpless, N.E. Ink4a/Arf Expression Is a Biomarker of Aging. J. Clin. Investig. 2004, 114, 1299–1307. [CrossRef] [PubMed]
248. Ressler, S.; Bartkova, J.; Niederegger, H.; Bartek, J.; Scharffetter-Kochanek, K.; Jansen-Dürr, P.; Wlaschek, M. P16INK4A Is a Robust in Vivo Biomarker of Cellular Aging in Human Skin. Aging Cell 2006, 5, 379–389. [CrossRef]
249. Jeck, W.R.; Siebold, A.P.; Sharpless, N.E. Review: A Meta-Analysis of GWAS and Age-Associated Diseases. Aging Cell 2012, 11, 727–731. [CrossRef] [PubMed]
250. Baker, D.J.; Childs, B.G.; Durik, M.; Wijers, M.E.; Sieben, C.J.; Zhong, J.A.; Saltness, R.; Jeganathan, K.B.; Verzosa, G.C.; Pezeshki, A.; et al. Naturally Occurring P16 Ink4a-Positive Cells Shorten Healthy Lifespan. Nature 2016, 530, 184–189. [CrossRef] [PubMed]
251. Xu, M.; Pirtskhalava, T.; Farr, J.N.; Weigand, B.M.; Palmer, A.K.; Weivoda, M.M.; Inman, C.L.; Ogrodnik, M.B.; Hachfeld, C.M.; Fraser, D.G.; et al. Senolytics Improve Physical Function and Increase Lifespan in Old Age. Nat. Med. 2018, 24, 1246–1256. [CrossRef]
252. López-Uriarte Patricia, P.; Nogués, R.; Saez, G.; Bulló, M.; Romeu, M.; Masana, L.; Tormos, C.; Casas-Agustench, P.; SalasSalvadó, J. Effect of Nut Consumption on Oxidative Stress and the Endothelial Function in Metabolic Syndrome. Clin. Nutr. 2010, 29, 373–380. [CrossRef] [PubMed]
253. Beauchamp, G.K.; Keast, R.S.J.; Morel, D.; Lin, J.; Pika, J.; Han, Q.; Lee, C.H.; Smith, A.B.; Breslin, P.A.S. Ibuprofen-like Activity in Extra-Virgin Olive Oil. Nature 2005, 437, 45–46. [CrossRef] [PubMed]
254. Rodríguez-Morató, J.; Xicota, L.; Fitó, M.; Farré, M.; Dierssen, M.; De La Torre, R. Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases. Molecules 2015, 20, 4655–4680. [CrossRef]
255. Umeno, A.; Takashima, M.; Murotomi, K.; Nakajima, Y.; Koike, T.; Matsuo, T.; Yoshida, Y. Radical-Scavenging Activity and Antioxidative Effects of Olive Leaf Components Oleuropein and Hydroxytyrosol in Comparison with Homovanillic Alcohol. J. Oleo Sci. 2015, 64, 793–800. [CrossRef]
256. Bussian, T.J.; Aziz, A.; Meyer, C.F.; Swenson, B.L.; van Deursen, J.M.; Baker, D.J. Clearance of Senescent Glial Cells Prevents Tau-Dependent Pathology and Cognitive Decline. Nature 2018, 562, 578–582. [CrossRef] [PubMed]
257. Gaikwad, S.; Puangmalai, N.; Bittar, A.; Montalbano, M.; Garcia, S.; McAllen, S.; Bhatt, N.; Sonawane, M.; Sengupta, U.; Kayed, R. Tau Oligomer Induced HMGB1 Release Contributes to Cellular Senescence and Neuropathology Linked to Alzheimer’s Disease and Frontotemporal Dementia. Cell Rep. 2021, 36, 109419. [CrossRef] [PubMed]
258. Hou, Y.; Wei, Y.; Lautrup, S.; Yang, B.; Wang, Y.; Cordonnier, S.; Mattson, M.P.; Croteau, D.L.; Bohr, V.A. NAD+ Supplementation Reduces Neuroinflammation and Cell Senescence in a Transgenic Mouse Model of Alzheimer’s Disease via CGAS-STING. Proc. Natl. Acad. Sci. USA 2021, 118, e2011226118. [CrossRef]
259. Li, Y.; Lu, J.; Cao, X.; Zhao, H.; Gao, L.; Xia, P.; Pei, G. A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer’s Amyloid- β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through Upregulating SIRT3. Oxidative Med. Cell. Longev. 2020, 2020, 7698560. [CrossRef]
260. Shang, D.; Hong, Y.; Xie, W.; Tu, Z.; Xu, J. Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress. Front. Neurol. 2020, 11, 929. [CrossRef]
261. Xie, Y.Y.; Pan, T.T.; Xu, D.E.; Huang, X.; Tang, Y.; Huang, W.; Chen, R.; Lu, L.; Chi, H.; Ma, Q.H. Clemastine Ameliorates Myelin Deficits via Preventing Senescence of Oligodendrocytes Precursor Cells in Alzheimer’s Disease Model Mouse. Front. Cell Dev. Biol. 2021, 9, 733945. [CrossRef]
262. Hu, Y.; Fryatt, G.L.; Ghorbani, M.; Obst, J.; Menassa, D.A.; Martin-Estebane, M.; Muntslag, T.A.O.; Olmos-Alonso, A.; GuerreroCarrasco, M.; Thomas, D.; et al. Replicative Senescence Dictates the Emergence of Disease-Associated Microglia and Contributes to Aβ Pathology. Cell Rep. 2021, 35, 109228. [CrossRef] [PubMed]
263. Mikuła-Pietrasik, J.; Sosi ´nska, P.; Murias, M.; Michalak, M.; Wierzchowski, M.; Piechota, M.; Sikora, E.; Ksiézek, K. Resveratrol Derivative, 3,30 ,4,40 -Tetrahydroxy-Trans-Stilbene, Retards Senescence of Mesothelial Cells via Hormetic-Like Prooxidative Mechanism. J. Gerontol.-Ser. A Biol. Sci. Med. Sci. 2014, 70, 1169–1180. [CrossRef] [PubMed]
264. Peltz, L.; Gomez, J.; Marquez, M.; Alencastro, F.; Atashpanjeh, N.; Quang, T.; Bach, T.; Zhao, Y. Resveratrol Exerts Dosage and Duration Dependent Effect on Human Mesenchymal Stem Cell Development. PLoS ONE 2012, 7, 37162. [CrossRef]
265. Hickson, L.T.J.; Langhi Prata, L.G.P.; Bobart, S.A.; Evans, T.K.; Giorgadze, N.; Hashmi, S.K.; Herrmann, S.M.; Jensen, M.D.; Jia, Q.; Jordan, K.L.; et al. Senolytics Decrease Senescent Cells in Humans: Preliminary Report from a Clinical Trial of Dasatinib plus Quercetin in Individuals with Diabetic Kidney Disease. EBioMedicine 2019, 47, 446–456. [CrossRef] [PubMed]
266. Mehdizadeh, M.; Aguilar, M.; Thorin, E.; Ferbeyre, G.; Nattel, S. The Role of Cellular Senescence in Cardiac Disease: Basic Biology and Clinical Relevance. Nat. Rev. Cardiol. 2022, 19, 250–264. [CrossRef] [PubMed]
267. Liberale, L.; Montecucco, F.; Tardif, J.C.; Libby, P.; Camici, G.G. Inflamm-Ageing: The Role of Inflammation in Age-Dependent Cardiovascular Disease. Eur. Heart J. 2020, 41, 2974–2982. [CrossRef] [PubMed]
268. Di Micco, R.; Krizhanovsky, V.; Baker, D.; d’Adda di Fagagna, F. Cellular Senescence in Ageing: From Mechanisms to Therapeutic Opportunities. Nat. Rev. Mol. Cell Biol. 2021, 22, 75–95. [CrossRef]
269. Paez-Ribes, M.; González-Gualda, E.; Doherty, G.J.; Muñoz-Espín, D. Targeting Senescent Cells in Translational Medicine. EMBO Mol. Med. 2019, 11, e10234. [CrossRef]
270. Collado, M.; Serrano, M. Senescence in Tumours: Evidence from Mice and Humans. Nat. Rev. Cancer 2010, 10, 51–57. [CrossRef]
271. Ewald, J.A.; Desotelle, J.A.; Wilding, G.; Jarrard, D.F. Therapy-Induced Senescence in Cancer. J. Natl. Cancer Inst. 2010, 102, 1536–1546. [CrossRef]
272. Yousefzadeh, M.J.; Zhu, Y.; McGowan, S.J.; Angelini, L.; Fuhrmann-Stroissnigg, H.; Xu, M.; Ling, Y.Y.; Melos, K.I.; Pirtskhalava, T.; Inman, C.L.; et al. Fisetin Is a Senotherapeutic That Extends Health and Lifespan. EBioMedicine 2018, 36, 18–28. [CrossRef]
273. Grosse, L.; Wagner, N.; Emelyanov, A.; Molina, C.; Lacas-Gervais, S.; Wagner, K.D.; Bulavin, D.V. Defined P16High Senescent Cell Types Are Indispensable for Mouse Healthspan. Cell Metab. 2020, 32, 87–99.e6. [CrossRef]
274. Omori, S.; Wang, T.W.; Johmura, Y.; Kanai, T.; Nakano, Y.; Kido, T.; Susaki, E.A.; Nakajima, T.; Shichino, S.; Ueha, S.; et al. Generation of a P16 Reporter Mouse and Its Use to Characterize and Target P16 High Cells In Vivo. Cell Metab. 2020, 32, 814–828.e6. [CrossRef]
275. Mihaylova, M.M.; Sabatini, D.M.; Yilmaz, Ö.H. Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer. Cell Stem Cell 2014, 14, 292–305. [CrossRef] [PubMed]
276. Gruver, A.L.; Hudson, L.L.; Sempowski, G.D. Immunosenescence of Ageing. J. Pathol. 2007, 211, 144–156. [CrossRef] [PubMed]
277. Rossi, D.J.; Bryder, D.; Seita, J.; Nussenzweig, A.; Hoeijmakers, J.; Weissman, I.L. Deficiencies in DNA Damage Repair Limit the Function of Haematopoietic Stem Cells with Age. Nature 2007, 447, 725–729. [CrossRef] [PubMed]
278. Janzen, V.; Forkert, R.; Fleming, H.E.; Saito, Y.; Waring, M.T.; Dombkowski, D.M.; Cheng, T.; DePinho, R.A.; Sharpless, N.E.; Scadden, D.T. Stem-Cell Ageing Modified by the Cyclin-Dependent Kinase Inhibitor P16INK4a. Nature 2006, 443, 421–426. [CrossRef] [PubMed]
279. Flores, I.; Blasco, M.A. The Role of Telomeres and Telomerase in Stem Cell Aging. FEBS Lett. 2010, 584, 3826–3830. [CrossRef]
280. Sharpless, N.E.; DePinho, R.A. How Stem Cells Age and Why This Makes Us Grow Old. Nature reviews. Mol. Cell Biol. 2007, 8, 703–713. [CrossRef]
281. Fulop, T.; Larbi, A.; Dupuis, G.; Page, A.L.; Frost, E.H.; Cohen, A.A.; Witkowski, J.M.; Franceschi, C. Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? Front. Immunol. 2018, 8, 1960. [CrossRef]
282. Cesari, F.; Sofi, F.; Molino Lova, R.; Vannetti, F.; Pasquini, G.; Cecchi, F.; Marcucci, R.; Gori, A.M.; Macchi, C.; Boni, R.; et al. Aging Process, Adherence to Mediterranean Diet and Nutritional Status in a Large Cohort of Nonagenarians: Effects on Endothelial Progenitor Cells. Nutr. Metab. Cardiovasc. Dis. 2018, 28, 84–90. [CrossRef]
283. Gulati, R.; Jevremovic, D.; Peterson, T.E.; Witt, T.A.; Kleppe, L.S.; Mueske, C.S.; Lerman, A.; Vile, R.G.; Simari, R.D. Autologous Culture-Modified Mononuclear Cells Confer Vascular Protection after Arterial Injury. Circulation 2003, 108, 1520–1526. [CrossRef]
284. Markoski, M.M.; Garavaglia, J.; Oliveira, A.; Olivares, J.; Marcadenti, A. Molecular Properties of Red Wine Compounds and Cardiometabolic Benefits. Nutr. Metab. Insights 2016, 9, 51–57. [CrossRef]
285. Parzonko, A.; Czerwi ´nska, M.E.; Kiss, A.K.; Naruszewicz, M. Oleuropein and Oleacein May Restore Biological Functions of Endothelial Progenitor Cells Impaired by Angiotensin II via Activation of Nrf2/Heme Oxygenase-1 Pathway. Phytomedicine 2013, 20, 1088–1094. [CrossRef] [PubMed]
286. Fernández-Real, J.M.; Bulló, M.; Moreno-Navarrete, J.M.; Ricart, W.; Ros, E.; Estruch, R.; Salas-Salvadó, J. A Mediterranean Diet Enriched with Olive Oil Is Associated with Higher Serum Total Osteocalcin Levels in Elderly Men at High Cardiovascular Risk. J. Clin. Endocrinol. Metab. 2012, 97, 3792–3798. [CrossRef] [PubMed]
287. Liu, H.; Huang, H.; Li, B.; Wu, D.; Wang, F.; Zheng, X.H.; Chen, Q.; Wu, B.; Fan, X. Olive Oil in the Prevention and Treatment of Osteoporosis after Artificial Menopause. Clin. Interv. Aging 2014, 9, 2087–2095. [CrossRef] [PubMed]
288. Shaw, A.C.; Joshi, S.; Greenwood, H.; Panda, A.; Lord, J.M. Aging of the Innate Immune System. Curr. Opin. Immunol. 2010, 22, 507–513. [CrossRef]
289. Samet, I. Effect of Olive Leaf Components on the Proliferation and Viability of Hematopoietic Stem Cells. Asian J. Biomed. Pharm. 2014, 4, 1–7. [CrossRef]
290. Chen, W.; Kang, J.; Xia, J.; Li, Y.; Yang, B.; Chen, B.; Sun, W.; Song, X.; Xiang, W.; Wang, X.; et al. P53-Related Apoptosis Resistance and Tumor Suppression Activity in UVB-Induced Premature Senescent Human Skin Fibroblasts. Int. J. Mol. Med. 2008, 21, 645–653. [CrossRef]
291. Marsh, D.; Dickinson, S.; Neill, G.W.; Marshall, J.F.; Hart, I.R.; Thomas, G.J. Alpha Vbeta 6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation. Cancer Res. 2008, 68, 3295–3303. [CrossRef]
292. Kang, J.; Chen, W.; Xia, J.; Li, Y.; Yang, B.; Chen, B.; Sun, W.; Song, X.; Xiang, W.; Wang, X.; et al. Extracellular Matrix Secreted by Senescent Fibroblasts Induced by UVB Promotes Cell Proliferation in HaCaT Cells through PI3K/AKT and ERK Signaling Pathways. Int. J. Mol. Med. 2008, 21, 777–784. [CrossRef]
293. Baxter, R.A. Anti-Aging Properties of Resveratrol: Review and Report of a Potent New Antioxidant Skin Care Formulation. J. Cosmet. Dermatol. 2008, 7, 2–7. [CrossRef]
294. Han, X.; Zhang, T.; Liu, H.; Mi, Y.; Gou, X. Astrocyte Senescence and Alzheimer’s Disease: A Review. Front. Aging Neurosci. 2020, 12, 148. [CrossRef]
295. Yurko-Mauro, K. Cognitive and Cardiovascular Benefits of Docosahexaenoic Acid in Aging and Cognitive Decline. Curr. Alzheimer Res. 2010, 7, 190–196. [CrossRef]
296. Ajith, T.A. A Recent Update on the Effects of Omega-3 Fatty Acids in Alzheimer’s Disease. Curr. Clin. Pharmacol. 2018, 13, 252–260. [CrossRef]
297. Colizzi, C. The Protective Effects of Polyphenols on Alzheimer’s Disease: A Systematic Review. Alzheimer’s Dement. Transl. Res. Clin. Interv. 2019, 5, 184. [CrossRef] [PubMed]
298. Gaudreault, R.; Mousseau, N. Mitigating Alzheimer’s Disease with Natural Polyphenols: A Review. Curr. Alzheimer Res. 2019, 16, 529–543. [CrossRef] [PubMed]
299. Zheng, Q.; Kebede, M.T.; Kemeh, M.M.; Islam, S.; Lee, B.; Bleck, S.D.; Wurfl, L.A.; Lazo, N.D. Inhibition of the Self-Assembly of Aβ and Tau by Polyphenols: Mechanistic Studies. Molecules 2019, 24, 2316. [CrossRef]
300. Ayaz, M.; Sadiq, A.; Junaid, M.; Ullah, F.; Ovais, M.; Ullah, I.; Ahmed, J.; Shahid, M. Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders. Front. Aging Neurosci. 2019, 11, 155. [CrossRef]
301. Mittelbrunn, M.; Sánchez-Madrid, F. Intercellular Communication: Diverse Structures for Exchange of Genetic Information. Nat. Rev. Mol. Cell Biol. 2012, 13, 328–335. [CrossRef]
302. Fransen, F.; van Beek, A.A.; Borghuis, T.; El Aidy, S.; Hugenholtz, F.; van der Gaast - de Jongh, C.; Savelkoul, H.F.J.; de Jonge, M.I.; Boekschoten, M.V.; Smidt, H.; et al. Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice. Front. Immunol. 2017, 8, 1385. [CrossRef] [PubMed]
303. Szarc Vel Szic, K.; Declerck, K.; Vidakovi´c, M.; Vanden Berghe, W. From Inflammaging to Healthy Aging by Dietary Lifestyle Choices: Is Epigenetics the Key to Personalized Nutrition? Clin. Epigenetics 2015, 7, 33. [CrossRef]
304. Xia, S.; Zhang, X.; Zheng, S.; Khanabdali, R.; Kalionis, B.; Wu, J.; Wan, W.; Tai, X. An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment. J. Immunol. Res. 2016, 2016, 8426874. [CrossRef]
305. Samieri, C.; Sun, Q.; Townsend, M.K.; Chiuve, S.E.; Okereke, O.I.; Willett, C.; Stampfer, M.; Grodstein, F. The Association between Dietary Patterns at Midlife and Health in Aging An Observational Study. Ann. Intern. Med. 2013, 159, 584–591. [CrossRef]
306. Frasca, D.; Blomberg, B.B. Inflammaging Decreases Adaptive and Innate Immune Responses in Mice and Humans. Biogerontology 2016, 17, 7–19. [CrossRef] [PubMed]
307. Michaud, M.; Balardy, L.; Moulis, G.; Gaudin, C.; Peyrot, C.; Vellas, B.; Cesari, M.; Nourhashemi, F. Proinflammatory Cytokines, Aging, and Age-Related Diseases. J. Am. Med. Dir. Assoc. 2013, 14, 877–882. [CrossRef]
308. Estruch, R.; Ngel Martínez-Gonzá Lez, M.Á.; Corella, D.; Salas-Salvadó, J.; Ruiz-Gutié Rrez, V.; Covas, M.I.; Fiol, M.; GóMezGracia, E.; López-Sabater, M.C. Effects of a Mediterranean-Style Diet on Cardiovascular Risk Factors A Randomized Trial. Ann. Intern. Med. 2006, 145, 1–11. [CrossRef] [PubMed]
309. Salas-Salvadó, J.; Garcia-Arellano, A.; Estruch, R.; Marquez-Sandoval, F.; Corella, D.; Fiol, M.; Gómez-Gracia, E.; Viñoles, E.; Arós, F.; Herrera, C.; et al. Components of the Mediterranean-Type Food Pattern and Serum Inflammatory Markers among Patients at High Risk for Cardiovascular Disease. Eur. J. Clin. Nutr. 2008, 62, 651–659. [CrossRef]
310. Zhang, X.; Cao, J.; Zhong, L. Hydroxytyrosol Inhibits Pro-Inflammatory Cytokines, INOS, and COX-2 Expression in Human Monocytic Cells. Naunyn-Schmiedeberg’s Arch. Pharmacol. 2009, 379, 581–586. [CrossRef] [PubMed]
311. Rosignoli, P.; Fuccelli, R.; Fabiani, R.; Servili, M.; Morozzi, G. Effect of Olive Oil Phenols on the Production of Inflammatory Mediators in Freshly Isolated Human Monocytes. J. Nutr. Biochem. 2013, 24, 1513–1519. [CrossRef]
312. Dell’Agli, M.; Fagnani, R.; Galli, G.V.; Maschi, O.; Gilardi, F.; Bellosta, S.; Crestani, M.; Bosisio, E.; De Fabiani, E.; Caruso, D. Olive Oil Phenols Modulate the Expression of Metalloproteinase 9 in THP-1 Cells by Acting on Nuclear Factor-KappaB Signaling. J. Agric. Food Chem. 2010, 58, 2246–2252. [CrossRef]
313. Arango, D.; Diosa-Toro, M.; Rojas-Hernandez, L.S.; Cooperstown, J.L.; Schwartz, S.J.; Mo, X.; Jiang, J.; Schmittgen, T.D.; Doseff, A.I. Dietary Apigenin Reduces LPS-Induced Expression of MiR-155 Restoring Immune Balance during Inflammation. Mol. Nutr. Food Res. 2015, 59, 763–772. [CrossRef]
314. Dell’Agli, M.; Fagnani, R.; Mitro, N.; Scurati, S.; Masciadri, M.; Mussoni, L.; Galli, G.V.; Bosisio, E.; Crestani, M.; De Fabiani, E.; et al. Minor Components of Olive Oil Modulate Proatherogenic Adhesion Molecules Involved in Endothelial Activation. J. Agric. Food Chem. 2006, 54, 3259–3264. [CrossRef]
315. Zambonin, L.; Caliceti, C.; Vieceli Dalla Sega, F.; Fiorentini, D.; Hrelia, S.; Landi, L.; Prata, C. Dietary Phenolic Acids Act as Effective Antioxidants in Membrane Models and Cultured Cells, Exhibiting Proapoptotic Effects in Leukaemia Cells. Oxidative Med. Cell. Longev. 2012, 2012, 839298. [CrossRef] [PubMed]
316. Meza-Miranda, E.R.; Rangel-Zúñiga, O.A.; Marín, C.; Pérez-Martínez, P.; Delgado-Lista, J.; Haro, C.; Peña-Orihuela, P.; JiménezMorales, A.I.; Malagón, M.M.; Tinahones, F.J.; et al. Virgin Olive Oil Rich in Phenolic Compounds Modulates the Expression of Atherosclerosis-Related Genes in Vascular Endothelium. Eur. J. Nutr. 2016, 55, 519–527. [CrossRef] [PubMed]
317. Camargo, A.; Ruano, J.; Fernandez, J.M.; Parnell, L.D.; Jimenez, A.; Santos-Gonzalez, M.; Marin, C.; Perez-Martinez, P.; Uceda, M.; Lopez-Miranda, J.; et al. Gene Expression Changes in Mononuclear Cells in Patients with Metabolic Syndrome after Acute Intake of Phenol-Rich Virgin Olive Oil. BMC Genom. 2010, 11, 253. [CrossRef] [PubMed]
318. Loud, S.; Berrougui, H.; Componova, P.; Ikhlef, S.; Helal, O.; Khalil, A. Extra-Virgin Olive Oil Consumption Reduces the Age-Related Decrease in HDL and Paraoxonase 1 Anti-Inflammatory Activities. Br. J. Nutr. 2013, 110, 1272–1284. [CrossRef] [PubMed]
319. Parhizkar, S.; Holtzman, D.M. APOE Mediated Neuroinflammation and Neurodegeneration in Alzheimer’s Disease. Semin. Immunol. 2022, 59, 101594. [CrossRef] [PubMed]
320. Solch, R.J.; Aigbogun, J.O.; Voyiadjis, A.G.; Talkington, G.M.; Darensbourg, R.M.; O’Connell, S.; Pickett, K.M.; Perez, S.R.; Maraganore, D.M. Mediterranean Diet Adherence, Gut Microbiota, and Alzheimer’s or Parkinson’s Disease Risk: A Systematic Review. J. Neurol. Sci. 2022, 434, 120166. [CrossRef]
321. Ciulla, M.; Marinelli, L.; Cacciatore, I.; Di Stefano, A. Role of Dietary Supplements in the Management of Parkinson’s Disease. Biomolecules 2019, 9, 271. [CrossRef]
322. Abdul-Latif, R.; Stupans, I.; Allahham, A.; Adhikari, B.; Thrimawithana, T. Natural Antioxidants in the Management of Parkinson’s Disease: Review of Evidence from Cell Line and Animal Models. J. Integr. Med. 2021, 19, 300–310. [CrossRef]
323. Guo, J.; Huang, X.; Dou, L.; Yan, M.; Shen, T.; Tang, W.; Li, J. Aging and Aging-Related Diseases: From Molecular Mechanisms to Interventions and Treatments. Signal Transduct. Target. Ther. 2022, 7, 391. [CrossRef]
324. Jia, S.; Xu, X.; Zhou, S.; Chen, Y.; Ding, G.; Cao, L. Fisetin Induces Autophagy in Pancreatic Cancer Cells via Endoplasmic Reticulum Stress- and Mitochondrial Stress-Dependent Pathways. Cell Death Dis. 2019, 10, 142. [CrossRef] [PubMed]
325. Tang, S.M.; Deng, X.T.; Zhou, J.; Li, Q.P.; Ge, X.X.; Miao, L. Pharmacological Basis and New Insights of Quercetin Action in Respect to Its Anti-Cancer Effects. Biomed. Pharmacother. 2020, 121, 109604. [CrossRef] [PubMed]
326. Borzì, A.M.; Biondi, A.; Basile, F.; Luca, S.; Vicari, E.S.D.; Vacante, M. Olive Oil Effects on Colorectal Cancer. Nutrients 2019, 11, 32. [CrossRef]
327. Giner, E.; Andújar, I.; Recio, M.C.; Ríos, J.L.; Cerdá-Nicolás, J.M.; Giner, R.M. Oleuropein Ameliorates Acute Colitis in Mice. J. Agric. Food Chem. 2011, 59, 12882–12892. [CrossRef] [PubMed]
328. Giner, E.; Recio, M.C.; Ríos, J.L.; Cerdá-Nicolás, J.M.; Giner, R.M. Chemopreventive Effect of Oleuropein in Colitis-Associated Colorectal Cancer in C57bl/6 Mice. Mol. Nutr. Food Res. 2016, 60, 242–255. [CrossRef] [PubMed]
329. Andrewes, P.; Busch, J.L.H.C.; De Joode, T.; Groenewegen, A.; Alexandre, H. Sensory Properties of Virgin Olive Oil Polyphenols: Identification of Deacetoxy-Ligstroside Aglycon as a Key Contributor to Pungency. J. Agric. Food Chem. 2003, 51, 1415–1420. [CrossRef] [PubMed]
330. García Rodríguez, L.A.; Huerta-Alvarez, C. Reduced Risk of Colorectal Cancer among Long-Term Users of Aspirin and Nonaspirin Nonsteroidal Antiinflammatory Drugs. Epidemiology 2001, 12, 88–93. [CrossRef]
331. Godos, J.; Biondi, A.; Galvano, F.; Basile, F.; Sciacca, S.; Giovannucci, E.L.; Grosso, G. Markers of Systemic Inflammation and Colorectal Adenoma Risk: Meta-Analysis of Observational Studies. World J. Gastroenterol. 2017, 23, 1909–1919. [CrossRef]
332. Santangelo, C.; Varì, R.; Scazzocchio, B.; Files, C. Polyphenols, Intracellular Signalling, and Inflammation. Ann.-Ist. Super. Sanita 2007, 43, 394.
333. Jandhyala, S.M.; Talukdar, R.; Subramanyam, C.; Vuyyuru, H.; Sasikala, M.; Reddy, D.N. Role of the Normal Gut Microbiota. World J. Gastroenterol. 2015, 21, 8836–8847. [CrossRef]
334. Frank, D.N.; St Amand, A.L.; Feldman, R.A.; Boedeker, E.C.; Harpaz, N.; Pace, N.R. Molecular-Phylogenetic Characterization of Microbial Community Imbalances in Human Inflammatory Bowel Diseases. Proc. Natl. Acad. Sci. USA 2007, 104, 13780–13785. [CrossRef]
335. Power, S.E.; O’Toole, P.W.; Stanton, C.; Ross, R.P.; Fitzgerald, G.F. Intestinal Microbiota, Diet and Health. Br. J. Nutr. 2014, 111, 387–402. [CrossRef]
336. Arias, A.; Mach, N. Efecto de Los Probióticos En El Control de La Obesidad En Humanos: Hipótesis No Demostradas. Rev. Esp. Nutr. Hum. Y Diet. 2012, 16, 100–107. [CrossRef]
337. Castillo-Álvarez, F.; Marzo-Sola, M.E. Papel de La Microbiota Intestinal En El Desarrollo de Diferentes Enfermedades Neurológicas. Neurología 2022, 37, 492–498. [CrossRef] [PubMed]
338. Jeffery, I.B.; Lynch, D.B.; O’Toole, P.W. Composition and Temporal Stability of the Gut Microbiota in Older Persons. ISME J. 2016, 10, 170–182. [CrossRef] [PubMed]
339. Alang, N.; Kelly, C.R. Weight Gain after Fecal Microbiota Transplantation. Open Forum Infect. Dis. 2015, 2, ofv004. [CrossRef] [PubMed]
340. Mills, S.; Stanton, C.; Lane, J.A.; Smith, G.J.; Ross, R.P. Precision Nutrition and the Microbiome, Part I: Current State of the Science. Nutrients 2019, 11, 923. [CrossRef]
341. Rondanelli, M.; Giacosa, A.; Faliva, M.A.; Perna, S.; Allieri, F.; Castellazzi, A.M. Review on Microbiota and Effectiveness of Probiotics Use in Older. World J. Clin. Cases 2015, 3, 156–162. [CrossRef]
342. Claesson, M.J.; Cusack, S.; O’Sullivan, O.; Greene-Diniz, R.; De Weerd, H.; Flannery, E.; Marchesi, J.R.; Falush, D.; Dinan, T.; Fitzgerald, G.; et al. Composition, Variability, and Temporal Stability of the Intestinal Microbiota of the Elderly. Proc. Natl. Acad. Sci. USA 2011, 108, 4586–4591. [CrossRef]
343. Nagpal, R.; Mainali, R.; Ahmadi, S.; Wang, S.; Singh, R.; Kavanagh, K.; Kitzman, D.W.; Kushugulova, A.; Marotta, F.; Yadav, H. Gut Microbiome and Aging: Physiological and Mechanistic Insights. Nutr. Healthy Aging 2018, 4, 267–285. [CrossRef]
344. Kaliannan, K.; Wang, B.; Li, X.Y.; Kim, K.J.; Kang, J.X. A Host-Microbiome Interaction Mediates the Opposing Effects of Omega-6 and Omega-3 Fatty Acids on Metabolic Endotoxemia. Sci. Rep. 2015, 5. [CrossRef]
345. David, L.A.; Maurice, C.F.; Carmody, R.N.; Gootenberg, D.B.; Button, J.E.; Wolfe, B.E.; Ling, A.V.; Devlin, A.S.; Varma, Y.; Fischbach, M.A.; et al. Diet Rapidly and Reproducibly Alters the Human Gut Microbiome. Nature 2014, 505, 559–563. [CrossRef]
346. Clemente, J.C.; Ursell, L.K.; Parfrey, L.W.; Knight, R. The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell 2012, 148, 1258–1270. [CrossRef] [PubMed]
347. Richards, J.L.; Yap, Y.A.; McLeod, K.H.; MacKay, C.R.; Marinõ, E. Dietary Metabolites and the Gut Microbiota: An Alternative Approach to Control Inflammatory and Autoimmune Diseases. Clin. Transl. Immunol. 2016, 5, e82. [CrossRef] [PubMed]
348. Sreng, N.; Champion, S.; Martin, J.C.; Khelaifia, S.; Christensen, J.E.; Padmanabhan, R.; Azalbert, V.; Blasco-Baque, V.; Loubieres, P.; Pechere, L.; et al. Resveratrol-Mediated Glycemic Regulation Is Blunted by Curcumin and Is Associated to Modulation of Gut Microbiota. J. Nutr. Biochem. 2019, 72, 108218. [CrossRef]
349. Thorburn, A.N.; Macia, L.; Mackay, C.R. Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases. Immunity 2014, 40, 833–842. [CrossRef]
350. Tang, W.H.W.; Wang, Z.; Levison, B.S.; Koeth, R.A.; Britt, E.B.; Fu, X.; Wu, Y.; Hazen, S.L. Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk. N. Engl. J. Med. 2013, 368, 1575–1584. [CrossRef]
351. Zhu, W.; Gregory, J.C.; Org, E.; Buffa, J.A.; Gupta, N.; Wang, Z.; Li, L.; Fu, X.; Wu, Y.; Mehrabian, M.; et al. Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell 2016, 165, 111–124. [CrossRef]
352. Cornejo-Pareja, I.; Muñoz-Garach, A.; Clemente-Postigo, M.; Tinahones, F.J. Importance of Gut Microbiota in Obesity. Eur. J. Clin. Nutr. 2019, 72, 26–37. [CrossRef]
353. Anand, P.; Kunnumakara, A.B.; Sundaram, C.; Harikumar, K.B.; Tharakan, S.T.; Lai, O.S.; Sung, B.; Aggarwal, B.B. Cancer Is a Preventable Disease That Requires Major Lifestyle Changes. Pharm. Res. 2008, 25, 2097–2116. [CrossRef] [PubMed]
354. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans Biological Agents. Volume 100 B. A Review of Human Carcinogens. Iarc Monogr. Eval. Carcinog. Risks Hum. 2012, 100, 1.
355. Ostan, R.; Lanzarini, C.; Pini, E.; Scurti, M.; Vianello, D.; Bertarelli, C.; Fabbri, C.; Izzi, M.; Palmas, G.; Biondi, F.; et al. Inflammaging and Cancer: A Challenge for the Mediterranean Diet. Nutrients 2015, 7, 2589–2621. [CrossRef]
356. Louis, P.; Hold, G.L.; Flint, H.J. The Gut Microbiota, Bacterial Metabolites and Colorectal Cancer. Nat. Rev. Microbiol. 2014, 12, 661–672. [CrossRef]
357. Gill, C.I.R.; Rowland, I.R. Diet, and Cancer: Assessing the Risk. Br. J. Nutr. 2002, 88, s73–s87. [CrossRef] [PubMed]
358. Shin, N.R.; Whon, T.W.; Bae, J.W. Proteobacteria: Microbial Signature of Dysbiosis in Gut Microbiota. Trends Biotechnol. 2015, 33, 496–503. [CrossRef]
359. Ridlon, J.M.; Wolf, P.G.; Gaskins, H.R. Taurocholic Acid Metabolism by Gut Microbes and Colon Cancer. Gut Microbes 2016, 7, 201–215. [CrossRef]
360. Singh, N.; Gurav, A.; Sivaprakasam, S.; Brady, E.; Padia, R.; Shi, H.; Thangaraju, M.; Prasad, P.D.; Manicassamy, S.; Munn, D.H.; et al. Activation of Gpr109a, the Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation, and Carcinogenesis. Immunity 2014, 40, 128–139. [CrossRef]
361. Larrosa, M.; González-Sarrías, A.; Yáñez-Gascón, M.J.; Selma, M.V.; Azorín-Ortuño, M.; Toti, S.; Tomás-Barberán, F.; Dolara, P.; Espín, J.C. Anti-Inflammatory Properties of a Pomegranate Extract and Its Metabolite Urolithin-A in a Colitis Rat Model and the Effect of Colon Inflammation on Phenolic Metabolism. J. Nutr. Biochem. 2010, 21, 717–725. [CrossRef] [PubMed]
362. Bhatt, A.P.; Redinbo, M.R.; Bultman, S.J. The Role of the Microbiome in Cancer Development and Therapy. CA A Cancer J. Clin. 2017, 67, 326–344. [CrossRef] [PubMed]
363. Martinez-Lapiscina, E.H.; Clavero, P.; Toledo, E.; Estruch, R.; Salas-Salvadó, J.; San Julián, B.; Sanchez-Tainta, A.; Ros, E.; Valls-Pedret, C.; Martinez-Gonzalez, M.A. Mediterranean Diet Improves Cognition: The PREDIMED-NAVARRA Randomised Trial. J. Neurol Neurosurg. Psychiatry 2013, 84, 1318–1325. [CrossRef] [PubMed]
364. Valls-Pedret, C.; Sala-Vila, A.; Serra-Mir, M.; Corella, D.; De La Torre, R.; Martínez-González, M.Á.; Martínez-Lapiscina, E.H.; Fitó, M.; Pérez-Heras, A.; Salas-Salvadó, J.; et al. Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial. JAMA Intern. Med. 2015, 175, 1094–1103. [CrossRef]
365. Marseglia, A.; Xu, W.; Fratiglioni, L.; Fabbri, C.; Berendsen, A.A.M.; Bialecka-Debek, A.; Jennings, A.; Gillings, R.; Meunier, N.; Caumon, E.; et al. Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults: A Randomized Controlled Trial. Front. Physiol. 2018, 9, 349. [CrossRef] 3
366. Loughrey, D.G.; Lavecchia, S.; Brennan, S.; Lawlor, B.A.; Kelly, M.E. The Impact of the Mediterranean Diet on the Cognitive Functioning of Healthy Older Adults: A Systematic Review and Meta-Analysis. Adv. Nutr. 2017, 8, 571–586. [CrossRef] [PubMed]
367. Servick, K. Do Gut Bacteria Make a Second Home in Our Brains? Science 2018. [CrossRef]
368. Pistollato, F.; Iglesias, R.C.; Ruiz, R.; Aparicio, S.; Crespo, J.; Lopez, L.D.; Manna, P.P.; Giampieri, F.; Battino, M. Nutritional Patterns Associated with the Maintenance of Neurocognitive Functions and the Risk of Dementia and Alzheimer’s Disease: A Focus on Human Studies. Pharmacol. Res. 2018, 131, 32–43. [CrossRef] [PubMed]
369. Kowalski, K.; Mulak, A. Brain-Gut-Microbiota Axis in Alzheimer’s Disease. J. Neurogastroenterol. Motil. 2019, 25, 48–60. [CrossRef] [PubMed]
370. Sochocka, M.; Donskow-Łysoniewska, K.; Diniz, B.S.; Kurpas, D.; Brzozowska, E.; Leszek, J. The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—A Critical Review. Mol. Neurobiol. 2019, 56, 1841–1851. [CrossRef]
371. Braakman, H.M.H.; van Ingen, J. Can epilepsy be treated by antibiotics? J. Neurol. 2018, 265, 1934–1936. [CrossRef] [PubMed]
372. Jin, M.; Qian, Z.; Yin, J.; Xu, W.; Zhou, X. The Role of Intestinal Microbiota in Cardiovascular Disease. J. Cell. Mol. Med. 2019, 23, 2343–2350. [CrossRef]
373. Minihane, A.M.; Vinoy, S.; Russell, W.R.; Baka, A.; Roche, H.M.; Tuohy, K.M.; Teeling, J.L.; Blaak, E.E.; Fenech, M.; Vauzour, D.; et al. Low-Grade Inflammation, Diet Composition, and Health: Current Research Evidence and Its Translation. Br. J. Nutr. 2015, 114, 999–1012. [CrossRef]
374. Garcia-Mantrana, I.; Selma-Royo, M.; Alcantara, C.; Collado, M.C. Shifts on Gut Microbiota Associated to Mediterranean Diet Adherence and Specific Dietary Intakes on General Adult Population. Front. Microbiol. 2018, 9, 890. [CrossRef]
375. Lange, K.W.; Guo, J.; Kanaya, S.; Lange, K.M.; Nakamura, Y.; Li, S. Medical Foods in Alzheimer’s Disease. Food Sci. Hum. Wellness 2019, 8, 1–7. [CrossRef]
376. Shannon, O.M.; Stephan, B.C.M.; Granic, A.; Lentjes, M.; Hayat, S.; Mulligan, A.; Brayne, C.; Khaw, K.T.; Bundy, R.; Aldred, S.; et al. Mediterranean Diet Adherence and Cognitive Function in Older UK Adults: The European Prospective Investigation into Cancer and Nutrition-Norfolk (EPIC-Norfolk) Study. Am. J. Clin. Nutr. 2019, 110, 938–948. [CrossRef] [PubMed]
377. Dey, N.; Wagner, V.E.; Blanton, L.V.; Cheng, J.; Fontana, L.; Haque, R.; Ahmed, T.; Gordon, J.I. Regulators of Gut Motility Revealed by a Gnotobiotic Model of Diet-Microbiome Interactions Related to Travel. Cell 2015, 163, 95–107. [CrossRef] [PubMed]
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