Neuroprotective Effect Of Cistanche Deserticola Cytological Pharmacological Effect

The functions and physiological processes of various organs and systems in the human body are not carried out in isolation, but under the direct or indirect regulation and control of the nervous system, they are interconnected, interacted, and closely coordinated, making the human body a complete and unified organism, realizing and maintaining normal life activities. At the same time, the human body lives in a constantly changing environment, and changes in the environment will inevitably affect various functions in the body at any time. This also requires the nervous system to continuously adjust various functions in the body quickly and comprehensively, so that the human body can adapt to changes in the internal and external environment. Therefore, the nervous system is the functional regulation system that plays a leading role in the body. At the same time, Cistanche deserticola deserticola, which has an obvious protective effect on nerve cells, is also favored by people.

Chinese herb cistanche

So far, nearly 70 compounds have been isolated from Cistanche plants, mainly including Phenethyl alcohol glycosides, Iridoid and their glycosides, lignans and their glycosides, alkaloids, sugars, and other components. Among them, it is reported that there are 6 monomers with clear neuroprotective effects, namely ergo side, campo side II, Verbascum thapsus glycoside, echinacoside, guanosine B, and Vernon side. Therefore, nonmo no mer components containing the above monomers, such as total glycosides of Cistanche deserticola, Phenethyl alcohol glycosides, and polysaccharides, also show neuroprotective effects.

Main Chemical Constituents of Cistanche deserticola

The Phenethyl alcohol glycoside compounds campneoside II, Verbascum thapsus flower glycoside, tracheoside B, and echinacin mainly affect MPP+, H2O2 (hydrogen peroxide), or THF- α The induced apoptosis of cerebellar granule cells, SH-SY5Y (neuroblastoma) cell injury, PC12 (adrenal Pheochromocytoma) neuron apoptosis have protective effects; Echinoside can reduce the behavior damage of mice caused by MPTP (Neurotoxin), increase the level of strip DA (dopamine) and DA metabolites, reduce cell death, and increase the expression of Tyrosine hydroxylase; Verbascum thapsus glycoside can improve the behavior of MPTP induced C57 mice, increase the content of DA transmitter, the number of DA ergic neurons and the substantia nigra Striatum α- Synuclein protein level;

Cistanche extract powder

Through effectively reducing the occurrence of H2O2 induced cell apoptosis, tracheoside B inhibits the production of reactive oxygen species free radicals and the increase of caspase-3 activity in cells, and maintains the high-energy state of mitochondrial membrane potential. These links are interconnected to jointly inhibit cell apoptosis and achieve neuroprotective effects. Phenethyl alcohol glycosides from Cistanche salsa can protect the apoptosis of rat Pheochromocytoma PC12 cells induced by amyloid 25-35 by improving the cell survival rate and reducing Lactate dehydrogenase activity.

Total glycosides of Cistanche deserticola deserticola (GCs) can increase the activity of Superoxide dismutase, that is, enhance the activity of the free radical scavenging enzyme, and achieve neuroprotective function by reducing the content of Malondialdehyde in brain tissue. Cistanche deserticola deserticola polysaccharide can inhibit neuronal apoptosis by enhancing the expression of Bel-2 and inhibiting the expression of Caspase-3, thus playing a role in protecting nerve cells.

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The damage and death of neural cells in the nervous system are pathological processes common to many systemic diseases and are also difficult and key points in the prevention and treatment of neurological diseases. Therefore, further deepening and improving the research on the mechanism of action of health products with neuroprotective effects is an urgent mission for pharmaceutical workers who aim to benefit the public.