Pharmacological Effects Of Cistanche Deserticola

Modern pharmacological research has shown that Cistanche deserticola has the effects of moistening the intestines, promoting bowel movements, improving sexual function, enhancing immunity, enhancing memory, anti-aging, anti-fatigue, anti apoptosis, anti-radiation, regulating the neuroendocrine system, protecting the liver, and preventing senile dementia.

Main Chemical Constituents of Cistanche deserticola

The water extracts of Desert Cistanche and Tubular Cistanche can significantly enhance the phagocytic ability of mouse peritoneal macrophages. The D-mannitol and polysaccharides in desert deserticola can significantly increase the spleen mass of mice and enhance cellular immune function; In addition, polysaccharides from Cistanche deserticola have a regulatory effect on mouse T cells, which can increase the proliferation response of mouse spleen and thymic lymphocytes. They also have a synergistic effect with concanavalin and plant blood agglutinin to stimulate the proliferation of mouse thymic lymphocytes, and can significantly increase the secretion of IL-2 by mouse spleen T lymphocytes.

Xiong Quanbo et al. reported that nine phenylethanolamine glycosides isolated from desert deserticola have significant free radical scavenging activity and anti-lipid peroxidation effects. They also found that the more phenolic hydroxyl groups in the molecule, the stronger the activity. It is speculated that phenylethanolamine glycosides are the main active components of desert deserticola for anti-oxidation.

Desert living cistanche-Antioxidant

The aqueous solution of Cistanche deserticola can significantly improve the intestinal motility of mice, significantly shorten their defecation time, and also have a significant inhibitory effect on the absorption of water in the large intestine. It shows that Cistanche deserticola has a significant laxative effect. The aqueous solution of Cistanche deserticola can cause contraction of rat gastric fundus strips and guinea pig ileum strips and can be inhibited by atropine, which is probably the moisturizing mechanism of Cistanche deserticola. Based on the above facts, it is speculated that it has cholinergic active ingredients and may be related to its laxative effect. One of the main active ingredients in Cistanche deserticola, betaine, has a very similar structure to choline. Therefore, it is speculated that the mechanism of Cistanche deserticola in moistening the intestines and promoting bowel movements is related to betaine.

effects of cistance-treat constipation 

Zhang Hongquan et al. studied the effect of desert Cistanche deserticola polysaccharides on CCl4-induced liver depression and spleen deficiency model mice. The results showed that desert deserticola polysaccharides could significantly improve appetite loss and weight loss in mice, and significantly counteract liver damage caused by CCl4. Xiong Quanbo et al. found that four phenylethanol glycoside compounds obtained from desert deserticola have hepatoprotective activity. In vitro experiments showed that all four compounds significantly inhibited lipid peroxidation in liver microsomes induced by NADPH-CCl4, inhibited the release of aspartate-aminotransferase-in cells, and reduced CCL4 and D-galactosamine-induced liver cell toxicity; In vivo experiments have shown that coelacanthin can effectively inhibit the release of alanine aminotransferase, thereby preventing the damage of CCL4 to the liver. It is believed that the phenylethyl and caffeoyl groups in the compound structure are active groups, which is related to their ability to scavenge free radicals and resist lipid peroxidation.

Zhan Hongming et al. observed the effect of total glycosides of phenylethanol from Salted Cistanche deserticola on the morphology of peripheral blood cells in mice after 60Co irradiation. They found that the lymphocyte diameter of the treated group mice significantly increased, and there were morphological changes similar to T lymphocyte transformation, indicating that Salted Cistanche deserticola can produce radiation protection by enhancing cellular immune function. Further research by Li Linlin et al. found that total glycosides can significantly promote the recovery of SOD activity in red blood cells and nucleic acid content in the spleen of irradiated mice. Inhibiting the formation of liver LPO indicates that its radiation protective effect is also closely related to its prevention of free radical damage and anti-lipid peroxidation effect; Histomorphology also indicates that Salted Cistanche deserticola can restore the structure of irradiated liver and spleen tissues and promote the synthesis of nucleic acids. Shi Dawen et al. compared the ethyl acetate extract or water extract of Cistanche deserticola, Saline Cistanche, Tubular Cistanche, and Sand Cistanche, and found that at a certain concentration, they all had the effect of activating human peripheral blood lymphocytes to kill human leukemia K562 cells. Among them, Tubular Cistanche had the strongest effect, followed by Desert Cistanche.

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Chinese scholars used a physical activity meter to observe the effect of desert deserticola extract on spontaneous movement in rats. The results showed that it can reduce spontaneous movement in rats, including horizontal movement, walking time, and movement distance. Among them, the water extract has the strongest effect. Further research shows that the reduced physical activity produced by desert deserticola water extract may be due to the reduction of dopamine activity, enhancement of serotonin, and gamma-aminobutyric acid activity. Mao Xinmin et al. found that the total glycosides of phenyl ethanol in Salted Cistanche deserticola can increase the activity of SOD and selenium glutathione peroxidase in mouse ischemia-reperfusion myocardium, reduce LPO content, and alleviate myocardial ultrafine particle structural damage; Significantly improve the electrocardiogram of myocardial ischemic rats, reduce myocardial infarction area, and increase the activity of phosphocreatine kinase in myocardial tissue. It has a protective effect on ischemic myocardium.

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