Study On Echinacoside Of Cistanche in The Treatment Of Diabetic Nephropathy

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The pathogenesis of diabetic nephropathy is complicated. At present, patients with diabetic nephropathy still lack effective clinical treatment methods. Finding new effective drugs is the key to the treatment of diabetic nephropathy. Echinacoside (ECH) in Cistanche is one of the effective ingredients of Cistanche extract, which has the effect of protecting the kidneys. Modern pharmacological studies have shown that Echinacoside in Cistanche has anti-oxidation, anti-apoptosis, anti-inflammatory, and pharmacological effects such as improving blood flow and microcirculation. It can regulate the body's sugar metabolism, improve glucose tolerance, and has the effect of treating diabetic nephropathy.

The Echinacoside in Cistanche can treat diabetic nephropathy

　　 In recent years, studies have shown that Echinacoside in Cistanche may inhibit the Transforming Growth Factor (TGF-β) signaling pathway, inhibit renal fibrosis in diabetic nephropathy rats, and protect rat kidney tissue. Echinacoside in Cistanche has a good effect on renal fibrosis and renal tissue cell apoptosis in diabetic nephropathy rats and its possible mechanism. Echinacoside in Cistanche has a significant effect on the treatment of diabetic nephropathy.

the Echinacoside in the treatment of diabetic nephropathy

"The protective effect of Echinacoside of Cistanche on renal function, renal tissue and mesangial cell damage in rats with diabetic nephropathy" experimental conclusion:

Low-dose Echinacoside has no obvious effect on the kidney tissue of rats with diabetic nephropathy, while medium and high-dose Echinacoside can significantly improve the pathological changes of kidney tissue in rats with diabetic nephropathy and improve renal tissue damage:

1. In this study, medium and high doses of Echinacoside in Cistanche may increase the body mass of rats with diabetic nephropathy by lowering blood sugar and reducing their water intake, urine output, and fasting blood sugar.

2. The results of this study suggest that Echinacoside of Cistanche may reduce blood sugar, improve kidney function, lower blood creatinine, urea nitrogen, and urine microalbumin levels, and improve renal tissue cell damage.

3. In this study, medium and high doses of Echinacoside in Cistanche can significantly down-regulate the expression of Bax and Caspase-3 mRNA in diabetic nephropathy rats, and up-regulate the expression of Bcl-2 mRNA. The Echinacoside of Cistanche can inhibit the apoptosis of a variety of cells and can protect kidney tissue from damage by inhibiting the apoptosis of renal tissue cells.

4. In this study, medium and high doses of Echinacoside can significantly down-regulate the expression of VCAM-1 protein in diabetic nephropathy rats, and inhibit renal tissue cell apoptosis in diabetic nephropathy rats.

5. In this study, medium and high doses of Echinacoside can significantly reduce the levels of HA, TIMP-1 and LN in diabetic nephropathy rats, and inhibit the occurrence and development of renal fibrosis.

6. In this study, medium and high doses of Echinacoside in Cistanche can significantly down-regulate the expression of TGF-β and α-SMA proteins in diabetic nephropathy rats, and inhibit renal tissue fibrosis.

Summary: In summary, medium and high doses of Echinacoside in Cistanche can reduce blood sugar in rats with diabetic nephropathy. It may inhibit the renal interstitial fibers of rats with diabetic nephropathy by inhibiting the protein expression of TGF-β and VCAM-1. It can improve the renal function of rats by chemical and renal tissue cell apoptosis.

Echinacoside of Cistanche can improve the renal function of diabetic nephropathy