What Is Echinacoside And What Are The Benefits Of Echinacoside?
Mar 17, 2022
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Echinacoside is one of the main extracts of Cistanche tubulosa. The molecular formula of echinacoside: C35H46O20; molecular weight: 786.72; Properties of Echinacoside: white crystalline powder, soluble in methanol, ethanol, hot water, slightly soluble in ethyl acetate, derived from the rhizomes of Cistanche and purple daisy. Echinacoside mainly extracted from Cistanche, It is a phenylethanoid glycoside compound.
Echinacoside
Echinacoside is a highly potential Chinese medicine ingredient, which has many pharmacological effects such as anti-oxidation, anti-inflammatory, neuroprotection, improvement of learning and memory, anti-tumor, liver protection, etc., so it can be used in the treatment of multiple system diseases. Modern studies have shown that echinacoside enters the human body to nourish the kidney, nourish the essence, and protect the liver to achieve multiple pharmacological effects. Pharmacological studies on the effects of echinacoside have found that the echinacoside can anti-oxidation and anti-aging, it protects neurons and anti-inflammatory, it also promotes the healing of wounds, protects livers, protects bones, anti-tumor, it has immunomodulatory effects, echinacoside in addition to the above effects Besides, it also has anti-apoptosis and anti-diabetic effects.
Pharmacological effects of echinacoside are confirmed by researches as below:
(1) Antioxidant effect
Comparing the inhibitory effects of alkyl amides, polysaccharides, and caffeic acid derivatives in Echinacoside on the oxidation of human low-density lipoproteins in vitro, it is found that the combination of Echinacoside and alkyl amides or macromolecular polysaccharides has a synergistic antioxidant effect, that is, the biological effect of Echinacoside. The activity is synergistically produced by a variety of ingredients in its preparation. Echinacoside plays an important role in protecting DNA from damage. In short, a large number of studies have shown that Echinacoside is a good natural antioxidant.
(2) Neuroprotection
Echinacoside has a significant protective effect on the apoptosis of nerve cells SHSY5Y induced by tumor necrosis factor (TNF-α). Its mechanism is to maintain the function of mitochondria through antioxidant effects, reduce the level of intracellular reactive oxygen species, inhibit the activity of caspase-3 And maintain the high-energy state of mitochondrial membrane potential. Since Echinacoside has strong anti-apoptotic activity, it may be used to treat neurodegenerative and nervous system diseases including neuronal apoptosis.
(3) Improve learning and memory
Echinacoside has an anti-aging effect, and its mechanism is that it can significantly inhibit O2−•, OH•, and other free radicals, and at the same time can increase the activity of GSH-Px and SOD, and reduce the content of MDA. Due to the inhibition of MAO activity, the memory of mice is improved. The results of this study indicate that the effects of Echinacoside on anti-lipid peroxidation and improving aging are related to its antioxidant activity. Echinacoside may improve the learning and memory ability of SAM-P/8 mice by improving the function of the central cholinergic system, increasing the total antioxidant capacity, promoting protein and nucleic acid synthesis, and regulating the immune status.
Ehinacoside in cistanche can improve memory
(4) Anti-inflammatory effect
(5) Anti-tumor effect
Studies have confirmed that the echinacoside from cistanche inhibits the proliferation of tumor cells, It can cause tumor cell apoptosis by blocking cells in the S phase. Echinacoside promotes the activation of the TGF-β1/Smad signaling pathway and increased the expression levels of Bax/Bcl-2. Moreover, Echinacoside could trigger the release of mitochondrial Cyto C, and cause the reaction Caspases grade.
Echinacoside Anti-tumor
(6) Liver protection
Verbascum glycosides, isoverbasin glycosides, 2'-acetyl Verbascum glycosides and echinacoside obtained from the Cistanche deserticola have significant hepatoprotective activities.
(7) Immunomodulatory effect
Echinacosides have regulatory effects and immunosuppressive activities on the human immune system. Echinacoside compounds can enhance the value of hemolysin and fibrinogen and have a strengthening effect on the body's non-specific immune function.
Echinacoside improves immune function
