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21
Dec, 2023
Estimating The Causal Effect Of Treatment With Direct-acting Antivirals On Ki...
Abstract Background Direct-acting antivirals (DAA) are highly effective at treating Hepatitis C virus (HCV) infection, with a cure rate > 95%. However, the effect of DAAs on kidney function rema...
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20
Dec, 2023
Stx2 Induces Differential Gene Expression And Disturbs Circadian Rhythm Genes...
3. Discussion 3.1. The Proximal Tubular Pathology in STEC Patients and Animal Models Oliguria is a sign of acute tubular necrosis (ATN). Because of ATN, sloughed epithelial cells obstruct the lumen...
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20
Dec, 2023
Stx2 Induces Differential Gene Expression And Disturbs Circadian Rhythm Genes...
Abstract: Shiga toxin-producing Escherichia coli (STEC) causes proximal tubular defects in the kidney. However, factors altered by Shiga toxin (Stx) within the proximal tubules are yet to be shown....
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20
Dec, 2023
JAK Inhibitor Blocks COVID-19-cytokine-induced JAK-STAT-APOL1 Signaling in Gl...
Our results shift the current paradigm of interferon-induced APOL1-nephropathy . Several examples in which high interferon states caused collapsing glomerulopathy in carriers of high-risk APOL1 gen...
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19
Dec, 2023
Metallothionein And Cadmium Toxicology—Historical Review And Commentary Ⅱ
4. Cadmium Toxicity and Its Modulation by Metallothioneins As mentioned in the introduction, clinical doctors first observed the toxic effects of Cd compounds. In 1858, Sovet reported [ 1 ] that re...
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18
Dec, 2023
Metallothionein And Cadmium Toxicology—Historical Review And Commentary
Abstract: More than one and a half centuries ago, adverse human health effects were reported after the use of a cadmium-containing silver polishing agent. Long-term cadmium exposure gives rise to k...
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18
Dec, 2023
JAK Inhibitor Blocks COVID-19-cytokine-induced JAK-STAT-APOL1 Signaling in Gl...
Abstract COVID-19 infection causes collapse of glomerular capillaries and loss of podocytes , terminating in a severe kidney disease called COVID-19-associated nephropathy (COVAN). The underlying m...
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18
Dec, 2023
Pediatric Adrenal Insufficiency: Challenges And Solutions Ⅱ
Genetic Disorders and Other Conditions at Increased Risk for Adrenal Insufficiency Among the cholesterol biosynthesis disorders, there is the Smith-Lemli-Opitz syndrome,23 where microcephaly, micro...
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18
Dec, 2023
Pediatric Adrenal Insufficiency: Challenges And Solutions
Abstract: Adrenal insufficiency is an insidious diagnosis that can be initially misdiagnosed as other life-threatening endocrine conditions, as well as sepsis, metabolic disorders , or cardiovascul...
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18
Dec, 2023
Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endoth...
3. Discussion Increased CYP1A1 and ROS production induced by AhR activation plays an integral role in the impairment of endothelium-dependent vasodilatation [24,25]. The results of the present stud...
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15
Dec, 2023
Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endoth...
Abstract: The uremic toxin indoxyl sulfate (IS), elevated in chronic kidney disease (CKD), is known to contribute to progressive cardiovascular disease. IS activates the aryl hydrocarbon receptor (...
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15
Dec, 2023
PGC-1α Inhibits The NLRP3 Inflammasome Via Preserving Mitochondrial Viability...
DISCUSSION The present study showed that PGC-1α mitigated mitochondrial damage and oxidative stress levels, restored mitochondrial integrity and TNFAIP3, and attenuated the activation of the NLRP3 ...