Elderly People Are Prone To Parkinson's Disease, And These Situations Should Be Taken Seriously
Aug 29, 2024
Parkinson's disease is a neurological disorder. Once Parkinson's disease appears, it indicates that our body's nervous system has serious problems. However, most friends are not very familiar with the symptoms of Parkinson's disease, so we must be familiar with its early symptoms. So what are the early symptoms of Parkinson's disease? Let's take a look together below.
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Symptoms of Parkinson's disease
Feeling abnormal:
Some Parkinson's patients may experience abnormal warmth or coldness in certain parts of their body, with more patients experiencing abnormal warmth. This abnormal temperature sensation often occurs in the hands and feet. Some patients may experience abnormal sensations on one side of the body or within the body, such as discomfort in the stomach or lower abdomen, which can have a significant impact on us. Therefore, it is important to learn to pay attention to such situations to better address the issue.
Pain:
Parkinson's patients all experience pain, and the common manifestations of Parkinson's disease are multifaceted. The common manifestations of Parkinson's disease include shoulder and neck pain, headache, back pain, as well as arm or leg soreness. Local muscle stiffness is the main cause, which has a significant impact on the elderly and can cause discomfort. Therefore, we undoubtedly need to pay attention to such situations.
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Lower limb swelling:
Parkinson's disease patients sometimes experience swelling in the lower limbs, and the common manifestations of Parkinson's disease mainly occur in the feet, which can affect the lower legs in severe cases. The lower limb on which the obstacle usually appears first. To alleviate this symptom, patients can exercise appropriately. When swelling is severe, symptomatic treatment can be taken, such as using some diuretic drugs.
make one's mouth water:
Many Parkinson's disease patients often experience drooling, and those with severe Parkinson's disease often require someone to hold a handkerchief and constantly wipe them. For young patients, anticholinergic drugs can be used to inhibit saliva secretion. However for elderly patients, it is not recommended to use it, they can consciously swallow their saliva.
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Causes of Parkinson's disease
The cause of Parkinson's disease may be family heredity. Some experts found that the cause of Parkinson's disease seems to be family clustering. The incidence rate of relatives of families with Parkinson's disease is higher than that of normal people.
It may also be caused by environmental factors. Statistics show that there are some regional differences in the incidence rate of Parkinson's disease. This phenomenon makes people suspect that there may be some toxic substances in the environment, which damage the neurons of the brain.
The cause of Parkinson's disease may also be genetic susceptibility. Although the occurrence of Parkinson's disease is closely related to environmental factors and aging, not all elderly people or those exposed to the same environment will develop Parkinson's disease. The etiology of Parkinson's disease is that although Parkinson's disease patients also have familial clustering, no clear pathogenic gene has been found in sporadic Parkinson's disease patients, indicating that the etiology of Parkinson's disease is multifactorial.
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Parkinson's disease is a common neurodegenerative disease characterized by motor dysfunction such as tremors, muscle stiffness, and motor delay. The pathogenesis of this disease is complex, involving a decrease in dopamine neurons, oxidative stress, neuroinflammation, and mitochondrial dysfunction.
Cistanche deserticola contains abundant phenylethanol glycosides, which have been proven to have significant neurodegenerative effects. The research by Tu Pengfei/Zeng Kewu's team found that Echinacoside (ECH) in Cistanche deserticola can activate the Wnt signaling pathway and promote mitochondrial fusion by specifically modifying the CK2 α 'protein, thereby exerting neuroprotective effects. In addition, Cistanche deserticola can also treat Parkinson's disease through various pathways such as antioxidant stress, regulation of neuroinflammation, regulation of cell autophagy, and inhibition of neuronal apoptosis.
Network pharmacology research further reveals the multi-target mechanism of Cistanche deserticola in treating Parkinson's disease. Research has found that multiple active ingredients in Cistanche deserticola can exert a comprehensive therapeutic effect by regulating various targets related to Parkinson's disease, such as dopamine receptors, acetylcholinesterase, angiotensin-converting enzyme, etc. These targets involve multiple aspects such as the regulation of neurotransmitters, inhibition of inflammatory responses, and control of cell apoptosis.
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In addition, it has been found that Cistanche deserticola can regulate gut microbiota, inhibit mitochondrial autophagy and oxidative damage, inhibit neuroinflammation and dopaminergic neuron apoptosis, and thus play a role in the treatment of Parkinson's disease. These findings provide new perspectives and strategies for the application of Cistanche deserticola in the treatment of Parkinson's disease.
In summary, as in traditional Chinese medicine, the potential of Cistanche deserticola in the treatment and prevention of Parkinson's disease cannot be ignored.
